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Items: 1 to 20 of 84

1.

Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules.

Ihantola EL, Ilmonen H, Kailaanmäki A, Rytkönen-Nissinen M, Azam A, Maillère B, Lindestam Arlehamn CS, Sette A, Motwani K, Seay HR, Brusko TM, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T.

J Immunol. 2020 Mar 30. pii: ji1901079. doi: 10.4049/jimmunol.1901079. [Epub ahead of print]

PMID:
32229538
2.

Innate inflammation drives NK cell activation to impair Treg activity.

Dean JW, Peters LD, Fuhrman CA, Seay HR, Posgai AL, Stimpson SE, Brusko MA, Perry DJ, Yeh WI, Newby BN, Haller MJ, Muir AB, Atkinson MA, Mathews CE, Brusko TM.

J Autoimmun. 2020 Mar;108:102417. doi: 10.1016/j.jaut.2020.102417. Epub 2020 Feb 6.

PMID:
32035746
3.

Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis.

Beam CA, Wasserfall C, Woodwyk A, Akers M, Rauch H, Blok T, Mason P, Vos D, Perry D, Brusko T, Peakman M, Atkinson M.

Sci Rep. 2020 Jan 20;10(1):672. doi: 10.1038/s41598-019-56951-5.

4.

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.

Shapiro MR, Wasserfall CH, McGrail SM, Posgai AL, Bacher R, Muir A, Haller MJ, Schatz DA, Wesley JD, von Herrath M, Hagopian WA, Speake C, Atkinson MA, Brusko TM.

Diabetes. 2020 Mar;69(3):413-423. doi: 10.2337/db19-0942. Epub 2019 Dec 11.

PMID:
31826866
5.

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.

Diabetes Care. 2020 Jan;43(1):5-12. doi: 10.2337/dc19-0880. Epub 2019 Nov 21.

PMID:
31753960
6.

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.

Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE.

J Exp Med. 2019 Nov 4;216(11):2479-2491. doi: 10.1084/jem.20190430. Epub 2019 Aug 29.

7.

Islet-immune interactions in type 1 diabetes: the nexus of beta cell destruction.

Peters L, Posgai A, Brusko TM.

Clin Exp Immunol. 2019 Dec;198(3):326-340. doi: 10.1111/cei.13349. Epub 2019 Aug 14. Review.

PMID:
31309537
8.

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances.

Ahmed S, Cerosaletti K, James E, Long SA, Mannering S, Speake C, Nakayama M, Tree T, Roep BO, Herold KC, Brusko TM.

Diabetes. 2019 Jul;68(7):1366-1379. doi: 10.2337/db19-0119.

9.

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.

Titov AA, Baker HV, Brusko TM, Sobel ES, Morel L.

J Immunol. 2019 Jul 15;203(2):338-348. doi: 10.4049/jimmunol.1801651. Epub 2019 Jun 3.

PMID:
31160534
10.

Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.

Shapiro MR, Atkinson MA, Brusko TM.

Curr Opin Endocrinol Diabetes Obes. 2019 Aug;26(4):188-194. doi: 10.1097/MED.0000000000000484.

PMID:
31145130
11.

Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.

Lewis JS, Stewart JM, Marshall GP, Carstens MR, Zhang Y, Dolgova NV, Xia C, Brusko TM, Wasserfall CH, Clare-Salzler MJ, Atkinson MA, Keselowsky BG.

ACS Biomater Sci Eng. 2019 May 13;5(5):2631-2646. doi: 10.1021/acsbiomaterials.9b00332. Epub 2019 Mar 26.

12.

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.

Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group.

Diabetes. 2019 Jun;68(6):1267-1276. doi: 10.2337/db19-0057. Epub 2019 Apr 9.

13.

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.

Khosravi-Maharlooei M, Obradovic A, Misra A, Motwani K, Holzl M, Seay HR, DeWolf S, Nauman G, Danzl N, Li H, Ho SH, Winchester R, Shen Y, Brusko TM, Sykes M.

J Clin Invest. 2019 Mar 28;129(6):2446-2462. doi: 10.1172/JCI124358.

14.

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.

Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA.

Immunity. 2019 Feb 19;50(2):362-377.e6. doi: 10.1016/j.immuni.2018.12.016. Epub 2019 Jan 29.

15.

A checkpoint on innate myeloid cells in pulmonary arterial hypertension.

Bryant AJ, Fu C, Lu Y, Brantly ML, Mehrad B, Moldawer LL, Brusko TM, Brittain EL, West JD, Austin ED, Hamid R.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018823528. doi: 10.1177/2045894018823528. Epub 2018 Dec 18. No abstract available.

16.

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.

Choi SC, Titov AA, Abboud G, Seay HR, Brusko TM, Roopenian DC, Salek-Ardakani S, Morel L.

Nat Commun. 2018 Oct 22;9(1):4369. doi: 10.1038/s41467-018-06686-0.

17.

Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.

Jacobsen LM, Newby BN, Perry DJ, Posgai AL, Haller MJ, Brusko TM.

Curr Diab Rep. 2018 Aug 30;18(10):90. doi: 10.1007/s11892-018-1066-5. Review.

PMID:
30168021
18.

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension.

Bryant AJ, Mehrad B, Brusko TM, West JD, Moldawer LL.

Int J Mol Sci. 2018 Aug 3;19(8). pii: E2277. doi: 10.3390/ijms19082277. Review.

19.

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.

Perry DJ, Wasserfall CH, Oram RA, Williams MD, Posgai A, Muir AB, Haller MJ, Schatz DA, Wallet MA, Mathews CE, Atkinson MA, Brusko TM.

Sci Rep. 2018 Mar 14;8(1):4529. doi: 10.1038/s41598-018-22574-5.

20.

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

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