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Items: 1 to 20 of 23


Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models.

Balducci C, Santamaria G, La Vitola P, Brandi E, Grandi F, Viscomi AR, Beeg M, Gobbi M, Salmona M, Ottonello S, Forloni G.

Neurobiol Aging. 2018 Oct;70:128-139. doi: 10.1016/j.neurobiolaging.2018.06.002. Epub 2018 Jun 12.


Utilization of the Monte Carlo Method to Build up QSAR Models for Hemolysis and Cytotoxicity of Antimicrobial Peptides.

Toropova AP, Toropov AA, Beeg M, Gobbi M, Salmona M.

Curr Drug Discov Technol. 2017;14(4):229-243. doi: 10.2174/1570163814666170525114128.


QSAR model for blood-brain barrier permeation.

Toropov AA, Toropova AP, Beeg M, Gobbi M, Salmona M.

J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):7-18. doi: 10.1016/j.vascn.2017.04.014. Epub 2017 May 2.


Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.

Romeo M, Stravalaci M, Beeg M, Rossi A, Fiordaliso F, Corbelli A, Salmona M, Gobbi M, Cagnotto A, Diomede L.

J Alzheimers Dis. 2017;57(3):857-871. doi: 10.3233/JAD-160951.


Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons.

Joshi P, Gabrielli M, Ponzoni L, Pelucchi S, Stravalaci M, Beeg M, Mazzitelli S, Braida D, Sala M, Boda E, Buffo A, Gobbi M, Gardoni F, Matteoli M, Marcello E, Verderio C.

Sci Rep. 2017 Jan 30;7:41734. doi: 10.1038/srep41734.


Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.

Diomede L, Romeo M, Rognoni P, Beeg M, Foray C, Ghibaudi E, Palladini G, Cherny RA, Verga L, Capello GL, Perfetti V, Fiordaliso F, Merlini G, Salmona M.

Antioxid Redox Signal. 2017 Sep 20;27(9):567-582. doi: 10.1089/ars.2016.6848. Epub 2017 Mar 3.


The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers.

Stravalaci M, Tapella L, Beeg M, Rossi A, Joshi P, Pizzi E, Mazzanti M, Balducci C, Forloni G, Biasini E, Salmona M, Diomede L, Chiesa R, Gobbi M.

J Alzheimers Dis. 2016 Jul 6;53(4):1485-97. doi: 10.3233/JAD-150882.


Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds.

Gobbi M, Beeg M, Toropova MA, Toropov AA, Salmona M.

Toxicol Lett. 2016 May 27;250-251:42-6. doi: 10.1016/j.toxlet.2016.04.010. Epub 2016 Apr 8.


Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.

Beeg M, Stravalaci M, Romeo M, Carrá AD, Cagnotto A, Rossi A, Diomede L, Salmona M, Gobbi M.

J Biol Chem. 2016 Mar 25;291(13):6958-66. doi: 10.1074/jbc.M115.689539. Epub 2016 Feb 16.


The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity.

Diomede L, Romeo M, Cagnotto A, Rossi A, Beeg M, Stravalaci M, Tagliavini F, Di Fede G, Gobbi M, Salmona M.

Neurobiol Dis. 2016 Apr;88:75-84. doi: 10.1016/j.nbd.2016.01.006. Epub 2016 Jan 11.


Different mutations at V363 MAPT codon are associated with atypical clinical phenotypes and show unusual structural and functional features.

Rossi G, Bastone A, Piccoli E, Morbin M, Mazzoleni G, Fugnanesi V, Beeg M, Del Favero E, Cantù L, Motta S, Salsano E, Pareyson D, Erbetta A, Elia AE, Del Sorbo F, Silani V, Morelli C, Salmona M, Tagliavini F.

Neurobiol Aging. 2014 Feb;35(2):408-17. doi: 10.1016/j.neurobiolaging.2013.08.004. Epub 2013 Sep 7.


Novel approaches for studying amyloidogenic peptides/proteins.

Beeg M, Diomede L, Stravalaci M, Salmona M, Gobbi M.

Curr Opin Pharmacol. 2013 Oct;13(5):797-801. doi: 10.1016/j.coph.2013.05.010. Epub 2013 Jun 3. Review.


Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans.

Stravalaci M, Bastone A, Beeg M, Cagnotto A, Colombo L, Di Fede G, Tagliavini F, Cantù L, Del Favero E, Mazzanti M, Chiesa R, Salmona M, Diomede L, Gobbi M.

J Biol Chem. 2012 Aug 10;287(33):27796-805. doi: 10.1074/jbc.M111.334979. Epub 2012 Jun 26.


In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells.

Arosio P, Owczarz M, Müller-Späth T, Rognoni P, Beeg M, Wu H, Salmona M, Morbidelli M.

PLoS One. 2012;7(3):e33372. doi: 10.1371/journal.pone.0033372. Epub 2012 Mar 14.


New mutations in MAPT gene causing frontotemporal lobar degeneration: biochemical and structural characterization.

Rossi G, Bastone A, Piccoli E, Mazzoleni G, Morbin M, Uggetti A, Giaccone G, Sperber S, Beeg M, Salmona M, Tagliavini F.

Neurobiol Aging. 2012 Apr;33(4):834.e1-6. doi: 10.1016/j.neurobiolaging.2011.08.008. Epub 2011 Sep 22.


A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)₁₋₄₀ and Aβ₁₋₄₂ from the corresponding depsipeptides.

Beeg M, Stravalaci M, Bastone A, Salmona M, Gobbi M.

Anal Biochem. 2011 Apr 15;411(2):297-9. doi: 10.1016/j.ab.2010.12.032. Epub 2010 Dec 24.


Use of surface plasmon resonance to study the elongation kinetics and the binding properties of the highly amyloidogenic Aβ(1-42) peptide, synthesized by depsi-peptide technique.

Stravalaci M, Beeg M, Salmona M, Gobbi M.

Biosens Bioelectron. 2011 Jan 15;26(5):2772-5. doi: 10.1016/j.bios.2010.10.038. Epub 2010 Oct 31.


Lipid-based nanoparticles with high binding affinity for amyloid-beta1-42 peptide.

Gobbi M, Re F, Canovi M, Beeg M, Gregori M, Sesana S, Sonnino S, Brogioli D, Musicanti C, Gasco P, Salmona M, Masserini ME.

Biomaterials. 2010 Sep;31(25):6519-29. doi: 10.1016/j.biomaterials.2010.04.044.


Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.

Taylor M, Moore S, Mayes J, Parkin E, Beeg M, Canovi M, Gobbi M, Mann DM, Allsop D.

Biochemistry. 2010 Apr 20;49(15):3261-72. doi: 10.1021/bi100144m.


Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.

Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2295-300. doi: 10.1073/pnas.0911829107. Epub 2010 Jan 19.

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