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Items: 1 to 20 of 147


A chemical approach for global protein knockdown from mice to non-human primates.

Sun X, Wang J, Yao X, Zheng W, Mao Y, Lan T, Wang L, Sun Y, Zhang X, Zhao Q, Zhao J, Xiao RP, Zhang X, Ji G, Rao Y.

Cell Discov. 2019 Feb 5;5:10. doi: 10.1038/s41421-018-0079-1. eCollection 2019.


Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives.

Woo AY, Ge XY, Pan L, Xing G, Mo YM, Xing RJ, Li XR, Zhang YY, Wainer IW, Cheng MS, Xiao RP.

Acta Pharmacol Sin. 2019 Jan 14. doi: 10.1038/s41401-018-0200-x. [Epub ahead of print]


Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis.

Wu HK, Zhang Y, Cao CM, Hu X, Fang M, Yao Y, Jin L, Chen G, Jiang P, Zhang S, Song R, Peng W, Liu F, Guo J, Tang L, He Y, Shan D, Huang J, Zhou Z, Wang DW, Lv F, Xiao RP.

Circulation. 2019 Feb 12;139(7):901-914. doi: 10.1161/CIRCULATIONAHA.118.037216.


Dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity-related type 2 diabetes mellitus.

Wang C, Xiao Y, Wang J, Hou N, Cui W, Hu X, Zeng F, Yuan Y, Ma D, Sun X, Zhang Y, Zheng W, Liu Y, Shang H, Chen L, Xiao RP, Zhang X.

Diabetes Obes Metab. 2018 Dec 21. doi: 10.1111/dom.13624. [Epub ahead of print]


ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure.

Huang J, Li C, Song Y, Fan X, You L, Tan L, Xiao L, Li Q, Ruan G, Hu S, Cui W, Li Z, Ni L, Chen C, Woo AY, Xiao RP, Wang DW.

Cell Discov. 2018 Oct 23;4:57. doi: 10.1038/s41421-018-0058-6. eCollection 2018.


Central role of RIPK1-VDAC1 pathway on cardiac impairment in a non-human primate model of rheumatoid arthritis.

Zeng F, Wen W, Cui W, Zheng W, Liu Y, Sun X, Hou N, Ma D, Yuan Y, Shi H, Wang Z, Li Z, Xiao Y, Wang C, Li Y, Shang H, Li C, Wang J, Zhang Y, Xiao RP, Zhang X.

J Mol Cell Cardiol. 2018 Dec;125:50-60. doi: 10.1016/j.yjmcc.2018.10.015. Epub 2018 Oct 17.


Characterization of spontaneously-developed non-alcoholic fatty liver disease in aged rhesus monkeys.

Zheng W, Liu Y, Shang H, Zhang Y, Ma D, Hou N, Wang J, Sun X, Peng Y, Pan L, Wang Z, Tang X, Xiao RP, Zhang X.

Diabetol Metab Syndr. 2018 Sep 10;10:68. doi: 10.1186/s13098-018-0370-1. eCollection 2018.


Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis.

Dai J, Liang K, Zhao S, Jia W, Liu Y, Wu H, Lv J, Cao C, Chen T, Zhuang S, Hou X, Zhou S, Zhang X, Chen XW, Huang Y, Xiao RP, Wang YL, Luo T, Xiao J, Wang C.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5896-E5905. doi: 10.1073/pnas.1801745115. Epub 2018 Jun 11.


Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.

Xiao Y, Wang C, Chen JY, Lu F, Wang J, Hou N, Hu X, Zeng F, Ma D, Sun X, Ding Y, Zhang Y, Zheng W, Liu Y, Shang H, Zhu W, Han C, Zhang Y, Ouyang K, Chen L, Chen J, Xiao RP, Li CY, Zhang X.

Nat Commun. 2018 May 22;9(1):2015. doi: 10.1038/s41467-018-04352-z.


RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis.

Zeng F, Chen X, Cui W, Wen W, Lu F, Sun X, Ma D, Yuan Y, Li Z, Hou N, Zhao H, Bi X, Zhao J, Zhou J, Zhang Y, Xiao RP, Cai J, Zhang X.

Cancer Res. 2018 Jun 1;78(11):2876-2885. doi: 10.1158/0008-5472.CAN-17-3082. Epub 2018 Mar 12.


MG53 and disordered metabolism in striated muscle.

Hu X, Xiao RP.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1984-1990. doi: 10.1016/j.bbadis.2017.10.013. Epub 2017 Oct 7. Review.


β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling.

Wang Y, Jin L, Song Y, Zhang M, Shan D, Liu Y, Fang M, Lv F, Xiao RP, Zhang Y.

Cardiovasc Res. 2017 Nov 1;113(13):1615-1626. doi: 10.1093/cvr/cvx147.


SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway.

Xie N, Chen M, Dai R, Zhang Y, Zhao H, Song Z, Zhang L, Li Z, Feng Y, Gao H, Wang L, Zhang T, Xiao RP, Wu J, Cao CM.

Nat Commun. 2017 Aug 11;8:16016. doi: 10.1038/ncomms16016.


MG53: Biological Function and Potential as a Therapeutic Target.

Zhang Y, Wu HK, Lv F, Xiao RP.

Mol Pharmacol. 2017 Sep;92(3):211-218. doi: 10.1124/mol.117.108241. Epub 2017 Apr 21. Review.


Biased Agonism at the Angiotensin Receptor: Blocker and Calcium Sensitizer at the Same Time.

Woo AY, Komuro I, Xiao RP.

Circulation. 2017 Mar 14;135(11):1071-1074. doi: 10.1161/CIRCULATIONAHA.117.027276. No abstract available.


HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage.

Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P.

J Clin Invest. 2017 Apr 3;127(4):1353-1369. doi: 10.1172/JCI85963. Epub 2017 Mar 13.


Making An Impact on Clinical Practice and Research in China.

Xiao RP, Wong GW, Prince JM, Gartside M, Zhao J, Wang J, Zhaori G, Drazen JM.

N Engl J Med. 2016 Dec 15;375(24):2391-2392. Epub 2016 Nov 21. No abstract available.


MG53 is a double-edged sword for human diseases.

Zhang Y, Wu HK, Lv FX, Xiao RP.

Sheng Li Xue Bao. 2016 Aug 25;68(4):505-16. Review.


Eplerenone restores 24-h blood pressure circadian rhythm and reduces advanced glycation end-products in rhesus macaques with spontaneous hypertensive metabolic syndrome.

Zhang Y, Zheng W, Liu Y, Wang J, Peng Y, Shang H, Hou N, Hu X, Ding Y, Xiao Y, Wang C, Zeng F, Mao J, Zhang J, Ma D, Sun X, Li C, Xiao RP, Zhang X.

Sci Rep. 2016 Apr 1;6:23957. doi: 10.1038/srep23957.


Interaction of β1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.

Zhu W, Tsang S, Browe DM, Woo AY, Huang Y, Xu C, Liu JF, Lv F, Zhang Y, Xiao RP.

JCI Insight. 2016;1(1):e84969.

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