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Items: 1 to 20 of 415

1.

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization.

Castaño Z, San Juan BP, Spiegel A, Pant A, DeCristo MJ, Laszewski T, Ubellacker JM, Janssen SR, Dongre A, Reinhardt F, Henderson A, Del Rio AG, Gifford AM, Herbert ZT, Hutchinson JN, Weinberg RA, Chaffer CL, McAllister SS.

Nat Cell Biol. 2018 Sep;20(9):1084-1097. doi: 10.1038/s41556-018-0173-5. Epub 2018 Aug 27.

PMID:
30154549
2.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers N, Chen M, Choi C, Collis LP, Crouse K, Färnegårdh M, Fennell KF, Fish S, Flick AC, Goos-Nilsson A, Gullberg H, Harris PK, Heasley SE, Hegen M, Hromockyj AE, Hu X, Husman B, Janosik T, Jones P, Kaila N, Kallin E, Kauppi B, Kiefer JR, Knafels J, Koehler K, Kruger L, Kurumbail RG, Kyne RE Jr, Li W, Löfstedt J, Long SA, Menard CA, Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D, Nuhant P, Pelc MJ, Prinsen MJ, Rhönnstad P, Backström-Rydin E, Sandberg J, Sandström M, Shah F, Sjöberg M, Sundell A, Taylor AP, Thorarensen A, Trujillo JI, Trzupek JD, Unwalla R, Vajdos FF, Weinberg RA, Wood DC, Xing L, Zamaratski E, Zapf CW, Zhao Y, Wilhelmsson A, Berstein G.

J Med Chem. 2018 Sep 9. doi: 10.1021/acs.jmedchem.8b00392. [Epub ahead of print]

PMID:
30130103
3.

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.

Li J, Choi PS, Chaffer CL, Labella K, Hwang JH, Giacomelli AO, Kim JW, Ilic N, Doench JG, Ly SH, Dai C, Hagel K, Hong AL, Gjoerup O, Goel S, Ge JY, Root DE, Zhao JJ, Brooks AN, Weinberg RA, Hahn WC.

Elife. 2018 Jul 30;7. pii: e37184. doi: 10.7554/eLife.37184.

4.

Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling.

Fröse J, Chen MB, Hebron KE, Reinhardt F, Hajal C, Zijlstra A, Kamm RD, Weinberg RA.

Cell Rep. 2018 Jul 24;24(4):962-972. doi: 10.1016/j.celrep.2018.06.092.

5.

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities.

Zhang Y, Weinberg RA.

Front Med. 2018 Aug;12(4):361-373. doi: 10.1007/s11684-018-0656-6. Epub 2018 Jul 24. Review.

PMID:
30043221
6.

Understanding the tumor immune microenvironment (TIME) for effective therapy.

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF.

Nat Med. 2018 May;24(5):541-550. doi: 10.1038/s41591-018-0014-x. Epub 2018 Apr 23. Review.

7.

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan3464. doi: 10.1126/scitranslmed.aan3464.

PMID:
29643230
8.

EMT in cancer.

Brabletz T, Kalluri R, Nieto MA, Weinberg RA.

Nat Rev Cancer. 2018 Feb;18(2):128-134. doi: 10.1038/nrc.2017.118. Epub 2018 Jan 12. Review.

PMID:
29326430
9.

The SUMO guards for SNAIL.

Ye X, Weinberg RA.

Oncotarget. 2017 Nov 15;8(58):97701-97702. doi: 10.18632/oncotarget.22432. eCollection 2017 Nov 17. No abstract available.

10.

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.

Guen VJ, Chavarria TE, Kröger C, Ye X, Weinberg RA, Lees JA.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10532-E10539. doi: 10.1073/pnas.1711534114. Epub 2017 Nov 20.

11.

Upholding a role for EMT in pancreatic cancer metastasis.

Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ.

Nature. 2017 Jul 5;547(7661):E7-E8. doi: 10.1038/nature22963. No abstract available.

12.

Upholding a role for EMT in breast cancer metastasis.

Ye X, Brabletz T, Kang Y, Longmore GD, Nieto MA, Stanger BZ, Yang J, Weinberg RA.

Nature. 2017 Jul 5;547(7661):E1-E3. doi: 10.1038/nature22816. No abstract available.

PMID:
28682326
13.

Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL.

J Exp Med. 2017 Aug 7;214(8):2243-2255. doi: 10.1084/jem.20161950. Epub 2017 Jun 30.

14.

Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas.

Dongre A, Rashidian M, Reinhardt F, Bagnato A, Keckesova Z, Ploegh HL, Weinberg RA.

Cancer Res. 2017 Aug 1;77(15):3982-3989. doi: 10.1158/0008-5472.CAN-16-3292. Epub 2017 Apr 20.

15.

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications.

Shibue T, Weinberg RA.

Nat Rev Clin Oncol. 2017 Oct;14(10):611-629. doi: 10.1038/nrclinonc.2017.44. Epub 2017 Apr 11. Review.

16.

LACTB is a tumour suppressor that modulates lipid metabolism and cell state.

Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt F, Thiru P, Golub TR, Vance JE, Weinberg RA.

Nature. 2017 Mar 30;543(7647):681-686. doi: 10.1038/nature21408. Epub 2017 Mar 22.

PMID:
28329758
17.

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346. doi: 10.1073/pnas.1618298114. Epub 2017 Mar 7.

18.

Emerging Biological Principles of Metastasis.

Lambert AW, Pattabiraman DR, Weinberg RA.

Cell. 2017 Feb 9;168(4):670-691. doi: 10.1016/j.cell.2016.11.037. Review.

19.

Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based Therapy.

Pattabiraman DR, Weinberg RA.

Cold Spring Harb Symp Quant Biol. 2016;81:11-19. doi: 10.1101/sqb.2016.81.030957. Epub 2017 Jan 5. Review.

20.

EMT, cell plasticity and metastasis.

Chaffer CL, San Juan BP, Lim E, Weinberg RA.

Cancer Metastasis Rev. 2016 Dec;35(4):645-654. doi: 10.1007/s10555-016-9648-7. Review.

PMID:
27878502

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