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Items: 16


Multiplexed profiling of GPCR activities by combining split TEV assays and EXT-based barcoded readouts.

Galinski S, Wichert SP, Rossner MJ, Wehr MC.

Sci Rep. 2018 May 25;8(1):8137. doi: 10.1038/s41598-018-26401-9.


Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.

Wehr MC, Hinrichs W, Brzózka MM, Unterbarnscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave KA, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ.

EMBO Mol Med. 2017 Oct;9(10):1448-1462. doi: 10.15252/emmm.201707691.


Characterizing Dynamic Protein-Protein Interactions Using the Genetically Encoded Split Biosensor Assay Technique Split TEV.

Wintgens JP, Rossner MJ, Wehr MC.

Methods Mol Biol. 2017;1596:219-238. doi: 10.1007/978-1-4939-6940-1_14.


Split protein biosensor assays in molecular pharmacological studies.

Wehr MC, Rossner MJ.

Drug Discov Today. 2016 Mar;21(3):415-29. doi: 10.1016/j.drudis.2015.11.004. Epub 2015 Nov 21. Review.


Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV.

Wehr MC, Galinski S, Rossner MJ.

Methods Mol Biol. 2015;1272:107-18. doi: 10.1007/978-1-4939-2336-6_8.


Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders.

Baier PC, Brzózka MM, Shahmoradi A, Reinecke L, Kroos C, Wichert SP, Oster H, Wehr MC, Taneja R, Hirrlinger J, Rossner MJ.

PLoS One. 2014 Oct 23;9(10):e110310. doi: 10.1371/journal.pone.0110310. eCollection 2014.


Evolutionary and molecular facts link the WWC protein family to Hippo signaling.

Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstädt H, Duning K, Kremerskothen J.

Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27.


Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.

Wehr MC, Holder MV, Gailite I, Saunders RE, Maile TM, Ciirdaeva E, Instrell R, Jiang M, Howell M, Rossner MJ, Tapon N.

Nat Cell Biol. 2013 Jan;15(1):61-71.


Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.

Ribeiro PS, Josué F, Wepf A, Wehr MC, Rinner O, Kelly G, Tapon N, Gstaiger M.

Mol Cell. 2010 Aug 27;39(4):521-34. doi: 10.1016/j.molcel.2010.08.002.


Kibra is a regulator of the Salvador/Warts/Hippo signaling network.

Genevet A, Wehr MC, Brain R, Thompson BJ, Tapon N.

Dev Cell. 2010 Feb 16;18(2):300-8. doi: 10.1016/j.devcel.2009.12.011.


Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.

Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA.

J Neurosci. 2009 May 13;29(19):6094-104. doi: 10.1523/JNEUROSCI.0686-09.2009.


Split-cre complementation indicates coincident activity of different genes in vivo.

Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F.

PLoS One. 2009;4(1):e4286. doi: 10.1371/journal.pone.0004286. Epub 2009 Jan 27.


Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice.

Rossner MJ, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, Eichele G, Taneja R, Nave KA.

PLoS One. 2008 Jul 23;3(7):e2762. doi: 10.1371/journal.pone.0002762.


Analysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split-TEV.

Wehr MC, Reinecke L, Botvinnik A, Rossner MJ.

BMC Biotechnol. 2008 Jul 13;8:55. doi: 10.1186/1472-6750-8-55.


Monitoring regulated protein-protein interactions using split TEV.

Wehr MC, Laage R, Bolz U, Fischer TM, Grünewald S, Scheek S, Bach A, Nave KA, Rossner MJ.

Nat Methods. 2006 Dec;3(12):985-93. Epub 2006 Oct 29.


High cholesterol level is essential for myelin membrane growth.

Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA.

Nat Neurosci. 2005 Apr;8(4):468-75. Epub 2005 Mar 27.


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