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Items: 1 to 20 of 50

1.

Effect of interior loop length on the thermal stability and pK(a) of i-motif DNA.

Reilly SM, Morgan RK, Brooks TA, Wadkins RM.

Biochemistry. 2015 Feb 17;54(6):1364-70. doi: 10.1021/bi5014722.

2.

Excited state proton transfer of natural flavonoids and their chromophores in duplex and tetraplex DNAs.

Sengupta B, Reilly SM, Davis DE Jr, Harris K, Wadkins RM, Ward D, Gholar D, Hampton C.

J Phys Chem B. 2015 Feb 12;119(6):2546-56. doi: 10.1021/jp508599h.

3.

Folding and hydrodynamics of a DNA i-motif from the c-MYC promoter determined by fluorescent cytidine analogs.

Reilly SM, Lyons DF, Wingate SE, Wright RT, Correia JJ, Jameson DM, Wadkins RM.

Biophys J. 2014 Oct 7;107(7):1703-11. doi: 10.1016/j.bpj.2014.08.014.

4.
5.

Epigenetic modification, dehydration, and molecular crowding effects on the thermodynamics of i-motif structure formation from C-rich DNA.

Bhavsar-Jog YP, Van Dornshuld E, Brooks TA, Tschumper GS, Wadkins RM.

Biochemistry. 2014 Mar 18;53(10):1586-94. doi: 10.1021/bi401523b.

6.

Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.

Yu X, Sigler SC, Hossain D, Wierdl M, Gwaltney SR, Potter PM, Wadkins RM.

J Mol Model. 2012 Jun;18(6):2869-83. doi: 10.1007/s00894-011-1308-9.

7.

Evaluation of fluorescent analogs of deoxycytidine for monitoring DNA transitions from duplex to functional structures.

Bhavsar YP, Reilly SM, Wadkins RM.

J Nucleic Acids. 2011;2011:986820. doi: 10.4061/2011/986820.

8.

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.

Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM.

Br J Pharmacol. 2010 Aug;160(8):1916-28. doi: 10.1111/j.1476-5381.2010.00700.x.

9.

In Silico Design and Evaluation of Carboxylesterase Inhibitors.

Stoddard SV, Yu X, Potter PM, Wadkins RM.

J Pest Sci (2004). 2010;35(3):240-249.

10.

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.

Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM.

J Med Chem. 2009 Jun 25;52(12):3742-52. doi: 10.1021/jm9001296.

11.

DNA hairpins containing the cytidine analog pyrrolo-dC: structural, thermodynamic, and spectroscopic studies.

Zhang X, Wadkins RM.

Biophys J. 2009 Mar 4;96(5):1884-91. doi: 10.1016/j.bpj.2008.12.3890.

12.

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.

Harada T, Nakagawa Y, Wadkins RM, Potter PM, Wheelock CE.

Bioorg Med Chem. 2009 Jan 1;17(1):149-64. doi: 10.1016/j.bmc.2008.11.008.

13.

Modifications of human carboxylesterase for improved prodrug activation.

Hatfield JM, Wierdl M, Wadkins RM, Potter PM.

Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1153-65. doi: 10.1517/17425255.4.9.1153 . Review.

14.

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM.

J Med Chem. 2007 Nov 15;50(23):5727-34.

PMID:
17941623
15.

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM.

Bioorg Med Chem. 2007 Jun 1;15(11):3801-17.

16.

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM.

J Med Chem. 2007 Apr 19;50(8):1876-85.

PMID:
17378546
17.

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.

Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM.

Mol Pharmacol. 2007 Mar;71(3):713-23.

18.

Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA.

Samudrala R, Zhang X, Wadkins RM, Mattern DL.

Bioorg Med Chem. 2007 Jan 1;15(1):186-93.

PMID:
17079147
19.

Carboxylesterases--detoxifying enzymes and targets for drug therapy.

Potter PM, Wadkins RM.

Curr Med Chem. 2006;13(9):1045-54. Review.

PMID:
16611083
20.

The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.

Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM.

Chem Biol Interact. 2005 Dec 15;157-158:153-7.

PMID:
16289500
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