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Items: 1 to 20 of 314

1.

Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS.

Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Gordon O, Pelch KE, Auerbach SS, Paules RS, DeVito MJ, Waalkes MP, Tokar EJ.

PLoS One. 2019 Apr 22;14(4):e0215504. doi: 10.1371/journal.pone.0215504. eCollection 2019.

2.

Cadmium down-regulates apolipoprotein E (ApoE) expression during malignant transformation of rat liver cells: direct evidence for DNA hypermethylation in the promoter region of ApoE.

Hirao-Suzuki M, Takeda S, Kobayashi T, Kino K, Miyazawa H, Waalkes MP, Takiguchi M.

J Toxicol Sci. 2018;43(9):537-543. doi: 10.2131/jts.43.537.

3.

NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation: Research Report 3 [Internet].

Morgan DL, Dixon D, King DH, Travlos GS, Herbert RA, French JE, Tokar EJ, Waalkes MP, Jokinen MP.

Durham (NC): National Toxicology Program; 2017 Aug.

4.

Cadmium-induced malignant transformation of rat liver cells: Potential key role and regulatory mechanism of altered apolipoprotein E expression in enhanced invasiveness.

Suzuki M, Takeda S, Teraoka-Nishitani N, Yamagata A, Tanaka T, Sasaki M, Yasuda N, Oda M, Okano T, Yamahira K, Nakamura Y, Kobayashi T, Kino K, Miyazawa H, Waalkes MP, Takiguchi M.

Toxicology. 2017 May 1;382:16-23. doi: 10.1016/j.tox.2017.03.014. Epub 2017 Mar 16.

PMID:
28315714
5.

Silencing KRAS Overexpression in Cadmium-Transformed Prostate Epithelial Cells Mitigates Malignant Phenotype.

Ngalame NN, Waalkes MP, Tokar EJ.

Chem Res Toxicol. 2016 Sep 19;29(9):1458-67. doi: 10.1021/acs.chemrestox.6b00137. Epub 2016 Aug 19.

6.

Mitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration.

Ngalame NN, Makia NL, Waalkes MP, Tokar EJ.

Toxicol Appl Pharmacol. 2016 Dec 1;312:11-18. doi: 10.1016/j.taap.2015.12.013. Epub 2015 Dec 22.

7.

Arsenic and Environmental Health: State of the Science and Future Research Opportunities.

Carlin DJ, Naujokas MF, Bradham KD, Cowden J, Heacock M, Henry HF, Lee JS, Thomas DJ, Thompson C, Tokar EJ, Waalkes MP, Birnbaum LS, Suk WA.

Environ Health Perspect. 2016 Jul;124(7):890-9. doi: 10.1289/ehp.1510209. Epub 2015 Nov 20. Review.

8.

Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.

Sharma NK, Kumar A, Kumari A, Tokar EJ, Waalkes MP, Bortner CD, Williams J, Ehrenshaft M, Mason RP, Sinha BK.

PLoS One. 2015 Nov 5;10(11):e0141897. doi: 10.1371/journal.pone.0141897. eCollection 2015.

9.

Chronic cadmium exposure in rats produces pancreatic impairment and insulin resistance in multiple peripheral tissues.

Treviño S, Waalkes MP, Flores Hernández JA, León-Chavez BA, Aguilar-Alonso P, Brambila E.

Arch Biochem Biophys. 2015 Oct 1;583:27-35. doi: 10.1016/j.abb.2015.07.010. Epub 2015 Aug 5.

PMID:
26253262
10.

Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium.

Pelch KE, Tokar EJ, Merrick BA, Waalkes MP.

Toxicol Appl Pharmacol. 2015 Aug 1;286(3):159-67. doi: 10.1016/j.taap.2015.04.011. Epub 2015 Apr 25.

11.

Chronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cells.

Person RJ, Ngalame NN, Makia NL, Bell MW, Waalkes MP, Tokar EJ.

Toxicol Appl Pharmacol. 2015 Jul 1;286(1):36-43. doi: 10.1016/j.taap.2015.03.014. Epub 2015 Mar 21.

12.

Macrophage solubilization and cytotoxicity of indium-containing particles as in vitro correlates to pulmonary toxicity in vivo.

Gwinn WM, Qu W, Bousquet RW, Price H, Shines CJ, Taylor GJ, Waalkes MP, Morgan DL.

Toxicol Sci. 2015 Mar;144(1):17-26. doi: 10.1093/toxsci/kfu273. Epub 2014 Dec 19.

13.

Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure.

Qu W, Waalkes MP.

Toxicol Appl Pharmacol. 2015 Feb 1;282(3):267-74. doi: 10.1016/j.taap.2014.11.014. Epub 2014 Dec 5.

14.

Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways.

Gao X, Yu L, Moore AB, Kissling GE, Waalkes MP, Dixon D.

Environ Health Perspect. 2015 Apr;123(4):331-6. doi: 10.1289/ehp.1408234. Epub 2014 Oct 24.

15.

Silencing KRAS overexpression in arsenic-transformed prostate epithelial and stem cells partially mitigates malignant phenotype.

Ngalame NN, Tokar EJ, Person RJ, Waalkes MP.

Toxicol Sci. 2014 Dec;142(2):489-96. doi: 10.1093/toxsci/kfu201. Epub 2014 Sep 30.

16.

Response to letter to the editor by Cohen et al. (2014) "Re: Waalkes et al.: Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses, Arch Toxicol, 2014".

Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D.

Arch Toxicol. 2014 Nov;88(11):2063-5. doi: 10.1007/s00204-014-1369-5. Epub 2014 Sep 25. No abstract available.

17.

Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses.

Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D.

Arch Toxicol. 2014 Aug;88(8):1619-29. doi: 10.1007/s00204-014-1305-8. Epub 2014 Jul 9.

18.

Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.

Ngalame NN, Tokar EJ, Person RJ, Xu Y, Waalkes MP.

Toxicol Sci. 2014 Apr;138(2):268-77. doi: 10.1093/toxsci/kfu002. Epub 2014 Jan 15.

19.

Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic.

Tokar EJ, Kojima C, Waalkes MP.

Arch Toxicol. 2014 Feb;88(2):249-61. doi: 10.1007/s00204-013-1141-2. Epub 2013 Oct 5.

20.

Arsenic-induced cancer cell phenotype in human breast epithelia is estrogen receptor-independent but involves aromatase activation.

Xu Y, Tokar EJ, Waalkes MP.

Arch Toxicol. 2014 Feb;88(2):263-74. doi: 10.1007/s00204-013-1131-4. Epub 2013 Sep 26.

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