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Spontaneous experimental atherosclerosis in hypercholesterolemic mice advances with ageing and correlates with mitochondrial reactive oxygen species.

Dorighello GG, Paim BA, Leite AC, Vercesi AE, Oliveira HC.

Exp Gerontol. 2017 Feb 14. pii: S0531-5565(16)30456-9. doi: 10.1016/j.exger.2017.02.010. [Epub ahead of print]


Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation.

Campos D, Ravagnani FG, Gurgueira SA, Vercesi AE, Teixeira SA, Costa SK, Muscará MN, Ferreira HH.

Int Immunopharmacol. 2016 Oct;39:57-62. doi: 10.1016/j.intimp.2016.07.009.


Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis.

Dorighello GG, Paim BA, Kiihl SF, Ferreira MS, Catharino RR, Vercesi AE, Oliveira HC.

Oxid Med Cell Longev. 2016;2016:7843685. doi: 10.1155/2016/7843685.


Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca²⁺-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P).

Ronchi JA, Henning B, Ravagnani FG, Figueira TR, Castilho RF, dos Reis SF, Vercesi AE.

Oxid Med Cell Longev. 2015;2015:940627. doi: 10.1155/2015/940627.


Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration.

Melo Hanchuk TD, Papa PF, La Guardia PG, Vercesi AE, Kobarg J.

Cell Signal. 2015 Jun;27(6):1168-77. doi: 10.1016/j.cellsig.2015.02.021.


Oxidative stress and susceptibility to mitochondrial permeability transition precedes the onset of diabetes in autoimmune non-obese diabetic mice.

Malaguti C, La Guardia PG, Leite AC, Oliveira DN, de Lima Zollner RL, Catharino RR, Vercesi AE, Oliveira HC.

Free Radic Res. 2014 Dec;48(12):1494-504. doi: 10.3109/10715762.2014.966706.


Mitochondrial calcium transport in trypanosomes.

Docampo R, Vercesi AE, Huang G.

Mol Biochem Parasitol. 2014 Sep;196(2):108-16. doi: 10.1016/j.molbiopara.2014.09.001. Review.


Liver proteomic response to hypertriglyceridemia in human-apolipoprotein C-III transgenic mice at cellular and mitochondrial compartment levels.

Ehx G, Gérin S, Mathy G, Franck F, Oliveira HC, Vercesi AE, Sluse FE.

Lipids Health Dis. 2014 Jul 21;13:116. doi: 10.1186/1476-511X-13-116.


Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.

Rossato FA, Zecchin KG, La Guardia PG, Ortega RM, Alberici LC, Costa RA, Catharino RR, Graner E, Castilho RF, Vercesi AE.

PLoS One. 2014 Jun 25;9(6):e101060. doi: 10.1371/journal.pone.0101060.


The Cratylia mollis seed lectin induces membrane permeability transition in isolated rat liver mitochondria and a cyclosporine a-insensitive permeability transition in Trypanosoma cruzi mitochondria.

Fernandes MP, Leite AC, Araújo FF, Saad ST, Baratti MO, Correia MT, Coelho LC, Gadelha FR, Vercesi AE.

J Eukaryot Microbiol. 2014 Jul-Aug;61(4):381-8. doi: 10.1111/jeu.12118.


A lectin from Bothrops leucurus snake venom raises cytosolic calcium levels and promotes B16-F10 melanoma necrotic cell death via mitochondrial permeability transition.

Aranda-Souza MA, Rossato FA, Costa RA, Figueira TR, Castilho RF, Guarniere MC, Nunes ES, Coelho LC, Correia MT, Vercesi AE.

Toxicon. 2014 May;82:97-103. doi: 10.1016/j.toxicon.2014.02.018.


Mass spectrometry imaging: a new vision in differentiating Schistosoma mansoni strains.

Ferreira MS, de Oliveira DN, de Oliveira RN, Allegretti SM, Vercesi AE, Catharino RR.

J Mass Spectrom. 2014 Jan;49(1):86-92. doi: 10.1002/jms.3308.


Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter.

Huang G, Vercesi AE, Docampo R.

Nat Commun. 2013;4:2865. doi: 10.1038/ncomms3865.


Food restriction by intermittent fasting induces diabetes and obesity and aggravates spontaneous atherosclerosis development in hypercholesterolaemic mice.

Dorighello GG, Rovani JC, Luhman CJ, Paim BA, Raposo HF, Vercesi AE, Oliveira HC.

Br J Nutr. 2014 Mar 28;111(6):979-86. doi: 10.1017/S0007114513003383.


Activation of the mitochondrial ATP-sensitive K+ channel reduces apoptosis of spleen mononuclear cells induced by hyperlipidemia.

Alberici LC, Paim BA, Zecchin KG, Mirandola SR, Pestana CR, Castilho RF, Vercesi AE, Oliveira HC.

Lipids Health Dis. 2013 Jun 14;12:87. doi: 10.1186/1476-511X-12-87.


A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities.

Ronchi JA, Figueira TR, Ravagnani FG, Oliveira HC, Vercesi AE, Castilho RF.

Free Radic Biol Med. 2013 Oct;63:446-56. doi: 10.1016/j.freeradbiomed.2013.05.049.


Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation.

La Guardia PG, Alberici LC, Ravagnani FG, Catharino RR, Vercesi AE.

Front Physiol. 2013 May 15;4:103. doi: 10.3389/fphys.2013.00103.


Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin.

Costa RA, Fernandes MP, de Souza-Pinto NC, Vercesi AE.

Eur J Pharmacol. 2013 Feb 15;701(1-3):82-6. doi: 10.1016/j.ejphar.2013.01.001.


Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health.

Figueira TR, Barros MH, Camargo AA, Castilho RF, Ferreira JC, Kowaltowski AJ, Sluse FE, Souza-Pinto NC, Vercesi AE.

Antioxid Redox Signal. 2013 Jun 1;18(16):2029-74. doi: 10.1089/ars.2012.4729. Review.

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