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A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.

Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P.

Cell Metab. 2019 May 17. pii: S1550-4131(19)30245-1. doi: 10.1016/j.cmet.2019.05.005. [Epub ahead of print]


Brown and Brite: The Fat Soldiers in the Anti-obesity Fight.

Srivastava S, Veech RL.

Front Physiol. 2019 Jan 30;10:38. doi: 10.3389/fphys.2019.00038. eCollection 2019. Review.


The "great" controlling nucleotide coenzymes.

Veech RL, Todd King M, Pawlosky R, Kashiwaya Y, Bradshaw PC, Curtis W.

IUBMB Life. 2019 May;71(5):565-579. doi: 10.1002/iub.1997. Epub 2019 Jan 9. Review.


Ketone bodies mimic the life span extending properties of caloric restriction.

Veech RL, Bradshaw PC, Clarke K, Curtis W, Pawlosky R, King MT.

IUBMB Life. 2017 May;69(5):305-314. doi: 10.1002/iub.1627. Epub 2017 Apr 3. Review.


Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease.

Pawlosky RJ, Kemper MF, Kashiwaya Y, King MT, Mattson MP, Veech RL.

J Neurochem. 2017 Apr;141(2):195-207. doi: 10.1111/jnc.13958. Epub 2017 Mar 15.


Novel ketone diet enhances physical and cognitive performance.

Murray AJ, Knight NS, Cole MA, Cochlin LE, Carter E, Tchabanenko K, Pichulik T, Gulston MK, Atherton HJ, Schroeder MA, Deacon RM, Kashiwaya Y, King MT, Pawlosky R, Rawlins JN, Tyler DJ, Griffin JL, Robertson J, Veech RL, Clarke K.

FASEB J. 2016 Dec;30(12):4021-4032. Epub 2016 Aug 15.


Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.

Cox PJ, Kirk T, Ashmore T, Willerton K, Evans R, Smith A, Murray AJ, Stubbs B, West J, McLure SW, King MT, Dodd MS, Holloway C, Neubauer S, Drawer S, Veech RL, Griffin JL, Clarke K.

Cell Metab. 2016 Aug 9;24(2):256-68. doi: 10.1016/j.cmet.2016.07.010. Epub 2016 Jul 27.


Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.

Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K.

J Biol Chem. 2016 May 13;291(20):10515-27. doi: 10.1074/jbc.M115.708982. Epub 2016 Mar 16.


The Population Pharmacokinetics of D-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate.

Shivva V, Cox PJ, Clarke K, Veech RL, Tucker IG, Duffull SB.

AAPS J. 2016 May;18(3):678-88. doi: 10.1208/s12248-016-9879-0. Epub 2016 Feb 18.


An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans.

Kemper MF, Srivastava S, Todd King M, Clarke K, Veech RL, Pawlosky RJ.

Lipids. 2015 Dec;50(12):1185-93. doi: 10.1007/s11745-015-4085-x. Epub 2015 Oct 26.


A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease.

Newport MT, VanItallie TB, Kashiwaya Y, King MT, Veech RL.

Alzheimers Dement. 2015 Jan;11(1):99-103. doi: 10.1016/j.jalz.2014.01.006. Epub 2014 Oct 7.


Ketone ester effects on metabolism and transcription.

Veech RL.

J Lipid Res. 2014 Oct;55(10):2004-6. doi: 10.1194/jlr.R046292. Epub 2014 Apr 8. Review.


Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.

Lendvai N, Pawlosky R, Bullova P, Eisenhofer G, Patocs A, Veech RL, Pacak K.

Endocrinology. 2014 Jan;155(1):27-32. doi: 10.1210/en.2013-1549. Epub 2013 Dec 20.


Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): role of ketone bodies.

Nakagawa T, Ge Q, Pawlosky R, Wynn RM, Veech RL, Uyeda K.

J Biol Chem. 2013 Sep 27;288(39):28358-67. doi: 10.1074/jbc.M113.498550. Epub 2013 Aug 5.


Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat.

Veech RL.

Ann N Y Acad Sci. 2013 Oct;1302:42-48. doi: 10.1111/nyas.12222. Epub 2013 Aug 2. Review.


A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.

Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL.

Neurobiol Aging. 2013 Jun;34(6):1530-9. doi: 10.1016/j.neurobiolaging.2012.11.023. Epub 2012 Dec 29.


A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice.

Srivastava S, Baxa U, Niu G, Chen X, Veech RL.

IUBMB Life. 2013 Jan;65(1):58-66. doi: 10.1002/iub.1102. Epub 2012 Dec 10. Erratum in: IUBMB Life. 2014 Jul;66(7):519.


Microwave irradiation decreases ATP, increases free [Mg²⁺], and alters in vivo intracellular reactions in rat brain.

Srivastava S, Kashiwaya Y, Chen X, Geiger JD, Pawlosky R, Veech RL.

J Neurochem. 2012 Dec;123(5):668-75. doi: 10.1111/jnc.12026.


Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects.

Clarke K, Tchabanenko K, Pawlosky R, Carter E, Todd King M, Musa-Veloso K, Ho M, Roberts A, Robertson J, Vanitallie TB, Veech RL.

Regul Toxicol Pharmacol. 2012 Aug;63(3):401-8. doi: 10.1016/j.yrtph.2012.04.008. Epub 2012 May 3.


Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate.

Clarke K, Tchabanenko K, Pawlosky R, Carter E, Knight NS, Murray AJ, Cochlin LE, King MT, Wong AW, Roberts A, Robertson J, Veech RL.

Regul Toxicol Pharmacol. 2012 Jul;63(2):196-208. doi: 10.1016/j.yrtph.2012.04.001. Epub 2012 Apr 11.

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