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Items: 1 to 20 of 217


Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity.

Tokumoto M, Lee JY, Shimada A, Tohyama C, Satoh M.

J Toxicol Sci. 2018;43(4):275-280. doi: 10.2131/jts.43.275.


Vocalization as a novel endpoint of atypical attachment behavior in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed infant mice.

Kimura E, Tohyama C.

Arch Toxicol. 2018 May;92(5):1741-1749. doi: 10.1007/s00204-018-2176-1. Epub 2018 Feb 14.


Roles of cytosolic phospholipase A2α in reproductive and systemic toxicities in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed mice.

Fujisawa N, Yoshioka W, Yanagisawa H, Tohyama C.

Arch Toxicol. 2018 Feb;92(2):789-801. doi: 10.1007/s00204-017-2081-z. Epub 2017 Oct 17.


Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse.

Kimura E, Kubo KI, Endo T, Ling W, Nakajima K, Kakeyama M, Tohyama C.

PLoS One. 2017 Aug 18;12(8):e0183497. doi: 10.1371/journal.pone.0183497. eCollection 2017.


Towards comprehensive health risk assessments of chemicals for occupational and environmental health.

Tohyama C.

Ind Health. 2017;55(3):199-200. doi: 10.2486/indhealth.55-199. No abstract available.


Association of impaired neuronal migration with cognitive deficits in extremely preterm infants.

Kubo KI, Deguchi K, Nagai T, Ito Y, Yoshida K, Endo T, Benner S, Shan W, Kitazawa A, Aramaki M, Ishii K, Shin M, Matsunaga Y, Hayashi K, Kakeyama M, Tohyama C, Tanaka KF, Tanaka K, Takashima S, Nakayama M, Itoh M, Hirata Y, Antalffy B, Armstrong DD, Yamada K, Inoue K, Nakajima K.

JCI Insight. 2017 May 18;2(10). pii: 88609. doi: 10.1172/jci.insight.88609. [Epub ahead of print]


Methylated site display (MSD)-AFLP, a sensitive and affordable method for analysis of CpG methylation profiles.

Aiba T, Saito T, Hayashi A, Sato S, Yunokawa H, Maruyama T, Fujibuchi W, Kurita H, Tohyama C, Ohsako S.

BMC Mol Biol. 2017 Mar 9;18(1):7. doi: 10.1186/s12867-017-0083-2.


Embryonic and Postnatal Expression of Aryl Hydrocarbon Receptor mRNA in Mouse Brain.

Kimura E, Tohyama C.

Front Neuroanat. 2017 Feb 7;11:4. doi: 10.3389/fnana.2017.00004. eCollection 2017.


Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse.

Kimura E, Kubo KI, Endo T, Nakajima K, Kakeyama M, Tohyama C.

J Toxicol Sci. 2017;42(1):25-30. doi: 10.2131/jts.42.25.


Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver.

Amenya HZ, Tohyama C, Ohsako S.

Sci Rep. 2016 Oct 7;6:34989. doi: 10.1038/srep34989.


Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice.

Yoshioka W, Kawaguchi T, Nishimura N, Akagi T, Fujisawa N, Yanagisawa H, Matsumura F, Tohyama C.

Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F752-F762. doi: 10.1152/ajprenal.00001.2016. Epub 2016 Jul 20.


In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice.

Sano K, Isobe T, Yang J, Win-Shwe TT, Yoshikane M, Nakayama SF, Kawashima T, Suzuki G, Hashimoto S, Nohara K, Tohyama C, Maekawa F.

Front Neurosci. 2016 Jun 3;10:228. doi: 10.3389/fnins.2016.00228. eCollection 2016.


In utero and lactational dioxin exposure induces Sema3b and Sema3g gene expression in the developing mouse brain.

Kimura E, Endo T, Yoshioka W, Ding Y, Ujita W, Kakeyama M, Tohyama C.

Biochem Biophys Res Commun. 2016 Jul 22;476(2):108-13. doi: 10.1016/j.bbrc.2016.05.048. Epub 2016 May 10.


Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice.

Aung KH, Kyi-Tha-Thu C, Sano K, Nakamura K, Tanoue A, Nohara K, Kakeyama M, Tohyama C, Tsukahara S, Maekawa F.

Front Neurosci. 2016 Mar 31;10:137. doi: 10.3389/fnins.2016.00137. eCollection 2016.


In Utero Bisphenol A Exposure Induces Abnormal Neuronal Migration in the Cerebral Cortex of Mice.

Ling W, Endo T, Kubo K, Nakajima K, Kakeyama M, Tohyama C.

Front Endocrinol (Lausanne). 2016 Feb 1;7:7. doi: 10.3389/fendo.2016.00007. eCollection 2016.


Developmental neurotoxicity test guidelines: problems and perspectives.

Tohyama C.

J Toxicol Sci. 2016;41(Spec):SP69-SP79. doi: 10.2131/jts.41.SP69. Review.


Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling.

Kimura E, Kubo K, Matsuyoshi C, Benner S, Hosokawa M, Endo T, Ling W, Kohda M, Yokoyama K, Nakajima K, Kakeyama M, Tohyama C.

Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt A):42-50. doi: 10.1016/ Epub 2015 Oct 23.


Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits.

Ishii K, Kubo K, Endo T, Yoshida K, Benner S, Ito Y, Aizawa H, Aramaki M, Yamanaka A, Tanaka K, Takata N, Tanaka KF, Mimura M, Tohyama C, Kakeyama M, Nakajima K.

J Neurosci. 2015 Sep 9;35(36):12432-45. doi: 10.1523/JNEUROSCI.3648-14.2015.


Application of NeuroTrace staining in the fresh frozen brain samples to laser microdissection combined with quantitative RT-PCR analysis.

Benner S, Kakeyama M, Endo T, Yoshioka W, Tohyama C.

BMC Res Notes. 2015 Jun 20;8:252. doi: 10.1186/s13104-015-1222-9.

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