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Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine.

Zhang Y, Chee A, Thonar EJ, An HS.

PM R. 2011 Jun;3(6 Suppl 1):S88-94. doi: 10.1016/j.pmrj.2011.04.020. Review. Erratum in: PM R. 2011 Aug;3(8):783.


Biologic repair and regeneration of the intervertebral disk.

An HS, Masuda K, Cs-Szabo G, Zhang Y, Chee A, Andersson GB, Im HJ, Thonar EJ, Kwon YM.

J Am Acad Orthop Surg. 2011 Jul;19(7):450-2. Review. No abstract available.


Transplantation of goat bone marrow stromal cells to the degenerating intervertebral disc in a goat disc injury model.

Zhang Y, Drapeau S, Howard SA, Thonar EJ, Anderson DG.

Spine (Phila Pa 1976). 2011 Mar 1;36(5):372-7. doi: 10.1097/BRS.0b013e3181d10401. No abstract available.


Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype.

Zhang Y, Markova D, Im HJ, Hu W, Thonar EJ, He TC, An HS, Phillips FM, Anderson DG.

Am J Phys Med Rehabil. 2009 Jun;88(6):455-63. doi: 10.1097/PHM.0b013e3181a5f0aa.


Immunophenotypes of macular corneal dystrophy in India and correlation with mutations in CHST6.

Sultana A, Klintworth GK, Thonar EJ, Vemuganti GK, Kannabiran C.

Mol Vis. 2009;15:319-25. Epub 2009 Feb 9.


Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc.

Singh K, Masuda K, Thonar EJ, An HS, Cs-Szabo G.

Spine (Phila Pa 1976). 2009 Jan 1;34(1):10-6. doi: 10.1097/BRS.0b013e31818e5ddd.


The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc.

Li X, Phillips FM, An HS, Ellman M, Thonar EJ, Wu W, Park D, Im HJ.

Spine (Phila Pa 1976). 2008 Nov 15;33(24):2586-95. doi: 10.1097/BRS.0b013e3181883883.


Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.

Zhang Y, An HS, Tannoury C, Thonar EJ, Freedman MK, Anderson DG.

Am J Phys Med Rehabil. 2008 Sep;87(9):694-702. doi: 10.1097/PHM.0b013e31817c1945. Review.


A cartilage growth mixture model with collagen remodeling: validation protocols.

Klisch SM, Asanbaeva A, Oungoulian SR, Masuda K, Thonar EJ, Davol A, Sah RL.

J Biomech Eng. 2008 Jun;130(3):031006. doi: 10.1115/1.2907754.


Action of fibroblast growth factor-2 on the intervertebral disc.

Li X, An HS, Ellman M, Phillips F, Thonar EJ, Park DK, Udayakumar RK, Im HJ.

Arthritis Res Ther. 2008;10(2):R48. doi: 10.1186/ar2407. Epub 2008 Apr 24.


Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model.

Zhang Y, Phillips FM, Thonar EJ, Oegema T, An HS, Roman-Blas JA, He TC, Anderson DG.

Spine (Phila Pa 1976). 2008 Apr 15;33(8):831-8. doi: 10.1097/BRS.0b013e31816b1f38.


Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee.

Chua SD Jr, Messier SP, Legault C, Lenz ME, Thonar EJ, Loeser RF.

Osteoarthritis Cartilage. 2008 Sep;16(9):1047-53. doi: 10.1016/j.joca.2008.02.002. Epub 2008 Mar 24.


Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair.

Zhang Y, Anderson DG, Phillips FM, Thonar EJ, He TC, Pietryla D, An HS.

Spine (Phila Pa 1976). 2007 Nov 1;32(23):2515-20.


Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes.

Im HJ, Li X, Muddasani P, Kim GH, Davis F, Rangan J, Forsyth CB, Ellman M, Thonar EJ.

J Cell Physiol. 2008 May;215(2):452-63.


An unusual presentation of macular corneal dystrophy associated with uniparental isodisomy and a novel Leu173Pro mutation.

Yellore VS, Sonmez B, Chen MC, Rayner SA, Thonar EJ, Aldave AJ.

Ophthalmic Genet. 2007 Sep;28(3):169-74.


Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network.

Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL.

Biomech Model Mechanobiol. 2008 Aug;7(4):263-76. Epub 2007 Aug 29.


Effect of osteogenic protein-1 on the matrix metabolism of bovine tendon cells.

Yamada M, Akeda K, Asanuma K, Thonar EJ, An HS, Uchida A, Masuda K.

J Orthop Res. 2008 Jan;26(1):42-8.


Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile.

Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL.

Osteoarthritis Cartilage. 2008 Jan;16(1):1-11. Epub 2007 Jul 16.


Articular cartilage mechanical and biochemical property relations before and after in vitro growth.

Ficklin T, Thomas G, Barthel JC, Asanbaeva A, Thonar EJ, Masuda K, Chen AC, Sah RL, Davol A, Klisch SM.

J Biomech. 2007;40(16):3607-14. Epub 2007 Jul 12.


Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain.

Chiba K, Masuda K, Andersson GB, Momohara S, Thonar EJ.

Spine J. 2007 Nov-Dec;7(6):694-700. Epub 2006 Dec 22.


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