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Items: 1 to 20 of 52


Improved post-thaw function and epigenetic changes in mesenchymal stromal cells cryopreserved using multicomponent osmolyte solutions.

Pollock K, Samsonraj R, Dudakovic A, Thaler R, Stumbras A, McKenna D, Dosa P, van Wijnen A, Hubel A.

Stem Cells Dev. 2017 Feb 8. doi: 10.1089/scd.2016.0347. [Epub ahead of print]


Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing.

Dudakovic A, Gluscevic M, Paradise CR, Dudakovic H, Khani F, Thaler R, Ahmed FS, Li X, Dietz AB, Stein GS, Montecino MA, Deyle DR, Westendorf JJ, van Wijnen AJ.

Gene. 2017 Apr 20;609:28-37. doi: 10.1016/j.gene.2017.01.019.


Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.

Khani F, Thaler R, Paradise CR, Deyle DR, Kruijthof-de Julio M, Galindo M, Gordon JA, Stein GS, Dudakovic A, van Wijnen AJ.

J Cell Biochem. 2016 Nov 9. doi: 10.1002/jcb.25787. [Epub ahead of print]


Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice.

Dudakovic A, Camilleri ET, Riester SM, Paradise CR, Gluscevic M, O'Toole TM, Thaler R, Evans JM, Yan H, Subramaniam M, Hawse JR, Stein GS, Montecino MA, McGee-Lawrence ME, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2016 Nov 18;291(47):24594-24606.


Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells.

Wiedemann GM, Knott MM, Vetter VK, Rapp M, Haubner S, Fesseler J, Kühnemuth B, Layritz P, Thaler R, Kruger S, Ormanns S, Mayr D, Endres S, Anz D.

Oncoimmunology. 2016 Apr 25;5(9):e1175794.


Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals Secretion of Proteins Related to Tumor Progression.

Jerez S, Araya H, Thaler R, Charlesworth MC, López-Solís R, Kalergis AM, Céspedes PF, Dudakovic A, Stein GS, van Wijnen AJ, Galindo M.

J Cell Biochem. 2017 Feb;118(2):351-360. doi: 10.1002/jcb.25642.


Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium.

Lewallen EA, Jones DL, Dudakovic A, Thaler R, Paradise CR, Kremers HM, Abdel MP, Kakar S, Dietz AB, Cohen RC, Lewallen DG, van Wijnen AJ.

Gene. 2016 May 1;581(2):95-106. doi: 10.1016/j.gene.2016.01.015.


Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate.

Thaler R, Maurizi A, Roschger P, Sturmlechner I, Khani F, Spitzer S, Rumpler M, Zwerina J, Karlic H, Dudakovic A, Klaushofer K, Teti A, Rucci N, Varga F, van Wijnen AJ.

J Biol Chem. 2016 Mar 25;291(13):6754-71. doi: 10.1074/jbc.M115.678235.


Multi-disciplinary antimicrobial strategies for improving orthopaedic implants to prevent prosthetic joint infections in hip and knee.

Getzlaf MA, Lewallen EA, Kremers HM, Jones DL, Bonin CA, Dudakovic A, Thaler R, Cohen RC, Lewallen DG, van Wijnen AJ.

J Orthop Res. 2016 Feb;34(2):177-86. doi: 10.1002/jor.23068. Review.


Suppression of intratumoral CCL22 by type i interferon inhibits migration of regulatory T cells and blocks cancer progression.

Anz D, Rapp M, Eiber S, Koelzer VH, Thaler R, Haubner S, Knott M, Nagel S, Golic M, Wiedemann GM, Bauernfeind F, Wurzenberger C, Hornung V, Scholz C, Mayr D, Rothenfusser S, Endres S, Bourquin C.

Cancer Res. 2015 Nov 1;75(21):4483-93. doi: 10.1158/0008-5472.CAN-14-3499.


Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2.

Dudakovic A, Camilleri ET, Xu F, Riester SM, McGee-Lawrence ME, Bradley EW, Paradise CR, Lewallen EA, Thaler R, Deyle DR, Larson AN, Lewallen DG, Dietz AB, Stein GS, Montecino MA, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2015 Nov 13;290(46):27604-17. doi: 10.1074/jbc.M115.672345.


Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells.

Varela N, Aranguiz A, Lizama C, Sepulveda H, Antonelli M, Thaler R, Moreno RD, Montecino M, Stein GS, van Wijnen AJ, Galindo M.

J Cell Physiol. 2016 May;231(5):1001-14. doi: 10.1002/jcp.25188.


Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells.

Lenertz LY, Baughman CJ, Waldschmidt NV, Thaler R, van Wijnen AJ.

Gene. 2015 Oct 1;570(1):1-7. doi: 10.1016/j.gene.2015.06.031. Review.


Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.

Karlic H, Thaler R, Gerner C, Grunt T, Proestling K, Haider F, Varga F.

Cancer Genet. 2015 May;208(5):241-52. doi: 10.1016/j.cancergen.2015.03.008.


Long-term outcome of patients with severe biventricular heart failure and severe mitral regurgitation after percutaneous edge-to-edge mitral valve repair.

Orban M, Braun D, Orban M, Grebmer C, Sibbing D, Thaler R, Tittus J, Wimbauer F, Lesevic H, Sonne C, Mehilli J, Ott I, Näbauer M, Massberg S, Boekstegers P, Hausleiter J.

J Interv Cardiol. 2015 Apr;28(2):164-71. doi: 10.1111/joic.12193.


Acute-phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis.

Thaler R, Sturmlechner I, Spitzer S, Riester SM, Rumpler M, Zwerina J, Klaushofer K, van Wijnen AJ, Varga F.

FASEB J. 2015 Apr;29(4):1344-59. doi: 10.1096/fj.14-265512.


The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia.

Karlic H, Herrmann H, Varga F, Thaler R, Reitermaier R, Spitzer S, Ghanim V, Blatt K, Sperr WR, Valent P, Pfeilstöcker M.

Crit Rev Oncol Hematol. 2014 Apr;90(1):1-16. doi: 10.1016/j.critrevonc.2013.10.003. Review.


Dangerous liaison: successful percutaneous edge-to-edge mitral valve repair in patients with end-stage systolic heart failure can cause left ventricular thrombus formation.

Orban M, Braun D, Sonne C, Orban M, Thaler R, Grebmer C, Lesevic H, Schömig A, Mehilli J, Massberg S, Hausleiter J.

EuroIntervention. 2014 Jun;10(2):253-9. doi: 10.4244/EIJV10I2A41.


Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover.

Braun T, Lepper J, Ruiz Heiland G, Hofstetter W, Siegrist M, Lezuo P, Gaestel M, Rumpler M, Thaler R, Klaushofer K, Distler JH, Schett G, Zwerina J.

J Bone Miner Res. 2013 Apr;28(4):936-47. doi: 10.1002/jbmr.1816.


Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells.

Thaler R, Spitzer S, Karlic H, Berger C, Klaushofer K, Varga F.

Biochem Pharmacol. 2013 Jan 15;85(2):173-85. doi: 10.1016/j.bcp.2012.10.016.

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