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Items: 1 to 20 of 505


Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons.

Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A.

Methods Enzymol. 2020;634:311-331. doi: 10.1016/bs.mie.2019.12.003. Epub 2020 Jan 17.


A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity.

Nelson L, Tighe A, Golder A, Littler S, Bakker B, Moralli D, Murtuza Baker S, Donaldson IJ, Spierings DCJ, Wardenaar R, Neale B, Burghel GJ, Winter-Roach B, Edmondson R, Clamp AR, Jayson GC, Desai S, Green CM, Hayes A, Foijer F, Morgan RD, Taylor SS.

Nat Commun. 2020 Feb 13;11(1):822. doi: 10.1038/s41467-020-14551-2.


Trans-specific Geriatric Health Assessment (TGHA): An inclusive clinical guideline for the geriatric transgender patient in a primary care setting.

Gamble RM, Taylor SS, Huggins AD, Ehrenfeld JM.

Maturitas. 2020 Feb;132:70-75. doi: 10.1016/j.maturitas.2019.12.005. Epub 2019 Dec 6. Review.


Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα.

Haushalter KJ, Schilling JM, Song Y, Sastri M, Perkins GA, Strack S, Taylor SS, Patel HH.

Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1231-H1242. doi: 10.1152/ajpheart.00237.2019. Epub 2019 Nov 1.


Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.

Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K, Calebiro D, Gao J, Bernlohr DA, Taylor SS, Veglia G.

Sci Adv. 2019 Aug 28;5(8):eaaw9298. doi: 10.1126/sciadv.aaw9298. eCollection 2019 Aug.


Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains.

Hao Y, England JP, Bellucci L, Paci E, Hodges HC, Taylor SS, Maillard RA.

Nat Commun. 2019 Sep 4;10(1):3984. doi: 10.1038/s41467-019-11930-2.


Oncogenic MYC amplifies mitotic perturbations.

Littler S, Sloss O, Geary B, Pierce A, Whetton AD, Taylor SS.

Open Biol. 2019 Aug 30;9(8):190136. doi: 10.1098/rsob.190136. Epub 2019 Aug 28.


BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E.

Sci Adv. 2019 Aug 14;5(8):eaav8463. doi: 10.1126/sciadv.aav8463. eCollection 2019 Aug.


Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP.

Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16347-16356. doi: 10.1073/pnas.1906036116. Epub 2019 Jul 30.


The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.

Schmidt SH, Knape MJ, Boassa D, Mumdey N, Kornev AP, Ellisman MH, Taylor SS, Herberg FW.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14979-14988. doi: 10.1073/pnas.1900289116. Epub 2019 Jul 10.


Dynamic allostery-based molecular workings of kinase:peptide complexes.

Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15052-15061. doi: 10.1073/pnas.1900163116. Epub 2019 Jul 8.


Development of germplasm repositories to assist conservation of endangered fishes: Examples from small-bodied livebearing fishes.

Liu Y, Blackburn H, Taylor SS, Tiersch TR.

Theriogenology. 2019 Sep 1;135:138-151. doi: 10.1016/j.theriogenology.2019.05.020. Epub 2019 May 28.


GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL.

Elife. 2019 May 21;8. pii: e43038. doi: 10.7554/eLife.43038.


Tuning the "violin" of protein kinases: The role of dynamics-based allostery.

Ahuja LG, Taylor SS, Kornev AP.

IUBMB Life. 2019 Jun;71(6):685-696. doi: 10.1002/iub.2057. Epub 2019 May 7. Review.


Evolution of a dynamic molecular switch.

Taylor SS, Meharena HS, Kornev AP.

IUBMB Life. 2019 Jun;71(6):672-684. doi: 10.1002/iub.2059. Epub 2019 May 6. Review.


Composite measures of physical activity and pain associate better with functional assessments than pain alone in knee osteoarthritis.

Allen KD, Lo G, Abbate LM, Floegel TA, Lindquist JH, Coffman C, Oddone EZ, Taylor SS, Hall K.

Clin Rheumatol. 2019 Aug;38(8):2241-2247. doi: 10.1007/s10067-019-04530-4. Epub 2019 Mar 30.


Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex.

Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A.

Sci Adv. 2019 Mar 20;5(3):eaav0482. doi: 10.1126/sciadv.aav0482. eCollection 2019 Mar.


Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα.

Cao B, Lu TW, Martinez Fiesco JA, Tomasini M, Fan L, Simon SM, Taylor SS, Zhang P.

Structure. 2019 May 7;27(5):816-828.e4. doi: 10.1016/j.str.2019.03.001. Epub 2019 Mar 21.


DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.

Pillay N, Tighe A, Nelson L, Littler S, Coulson-Gilmer C, Bah N, Golder A, Bakker B, Spierings DCJ, James DI, Smith KM, Jordan AM, Morgan RD, Ogilvie DJ, Foijer F, Jackson DA, Taylor SS.

Cancer Cell. 2019 Mar 18;35(3):519-533.e8. doi: 10.1016/j.ccell.2019.02.004.


Self-reported medication nonadherence predicts cholesterol levels over time.

Blalock DV, Zullig LL, Bosworth HB, Taylor SS, Voils CI.

J Psychosom Res. 2019 Mar;118:49-55. doi: 10.1016/j.jpsychores.2019.01.010. Epub 2019 Jan 18.


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