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Items: 1 to 20 of 288


DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation.

Cecil CAM, Walton E, Pingault JB, Provençal N, Pappa I, Vitaro F, Côté S, Szyf M, Tremblay RE, Tiemeier H, Viding E, McCrory EJ.

Am J Med Genet B Neuropsychiatr Genet. 2018 Dec;177(8):746-764. doi: 10.1002/ajmg.b.32689. Epub 2018 Nov 9.


P-Glycoprotein (P-gp)/ABCB1 plays a functional role in extravillous trophoblast (EVT) invasion and is decreased in the pre-eclamptic placenta.

Dunk CE, Pappas JJ, Lye P, Kibschull M, Javam M, Bloise E, Lye SJ, Szyf M, Matthews SG.

J Cell Mol Med. 2018 Nov;22(11):5378-5393. doi: 10.1111/jcmm.13810. Epub 2018 Sep 5.


A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention.

Lax E, Warhaftig G, Ohana D, Maayan R, Delayahu Y, Roska P, Ponizovsky AM, Weizman A, Yadid G, Szyf M.

Front Mol Neurosci. 2018 Sep 10;11:322. doi: 10.3389/fnmol.2018.00322. eCollection 2018.


Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.

Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L.

Transl Psychiatry. 2018 Aug 8;8(1):147. doi: 10.1038/s41398-018-0195-6.


Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates.

Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L.

Psychoneuroendocrinology. 2018 Nov;97:196-205. doi: 10.1016/j.psyneuen.2018.07.019. Epub 2018 Jul 27.


The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics.

Lax E, Szyf M.

Prog Mol Biol Transl Sci. 2018;157:93-104. doi: 10.1016/bs.pmbts.2018.01.003. Epub 2018 Apr 11.


Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women.

Cheishvili D, Parashar S, Mahmood N, Arakelian A, Kremer R, Goltzman D, Szyf M, Rabbani SA.

J Bone Miner Res. 2018 Nov;33(11):1980-1989. doi: 10.1002/jbmr.3527. Epub 2018 Jul 20.


DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse.

Farrell C, Doolin K, O' Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z, Szyf M, Booij L, O'Keane V.

Psychiatry Res. 2018 Jul;265:341-348. doi: 10.1016/j.psychres.2018.04.064. Epub 2018 May 8.


DNA methylation signatures of breast cancer in peripheral T-cells.

Parashar S, Cheishvili D, Mahmood N, Arakelian A, Tanvir I, Khan HA, Kremer R, Mihalcioiu C, Szyf M, Rabbani SA.

BMC Cancer. 2018 May 18;18(1):574. doi: 10.1186/s12885-018-4482-7.


Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial.

McMorrow AM, Connaughton RM, Magalhães TR, McGillicuddy FC, Hughes MF, Cheishvili D, Morine MJ, Ennis S, Healy ML, Roche EF, Tremblay RE, Szyf M, Lithander FE, Roche HM.

Mol Nutr Food Res. 2018 May;62(10):e1701008. doi: 10.1002/mnfr.201701008.


The DNA methylation landscape of enhancers in the guinea pig hippocampus.

Boureau L, Constantinof A, Moisiadis VG, Matthews SG, Szyf M.

Epigenomics. 2018 Apr 1;10(4):349-365. doi: 10.2217/epi-2017-0064. Epub 2018 Apr 4.


Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications.

Mahmood N, Cheishvili D, Arakelian A, Tanvir I, Khan HA, Pépin AS, Szyf M, Rabbani SA.

Oncotarget. 2017 Dec 26;9(4):5169-5183. doi: 10.18632/oncotarget.23704. eCollection 2018 Jan 12.


DNA methylation mediates the effect of maternal cognitive appraisal of a disaster in pregnancy on the child's C-peptide secretion in adolescence: Project Ice Storm.

Cao-Lei L, Dancause KN, Elgbeili G, Laplante DP, Szyf M, King S.

PLoS One. 2018 Feb 5;13(2):e0192199. doi: 10.1371/journal.pone.0192199. eCollection 2018.


The signature of liver cancer in immune cells DNA methylation.

Zhang Y, Petropoulos S, Liu J, Cheishvili D, Zhou R, Dymov S, Li K, Li N, Szyf M.

Clin Epigenetics. 2018 Jan 18;10:8. doi: 10.1186/s13148-017-0436-1. eCollection 2018.


S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice.

Ornoy A, Weinstein-Fudim L, Tfilin M, Ergaz Z, Yanai J, Szyf M, Turgeman G.

Neurotoxicol Teratol. 2018 Jan 16. pii: S0892-0362(17)30154-X. doi: 10.1016/ [Epub ahead of print]


S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells.

Wang Y, Sun Z, Szyf M.

Oncotarget. 2017 Dec 5;8(67):111866-111881. doi: 10.18632/oncotarget.22942. eCollection 2017 Dec 19.


Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.

Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T.

Neuropsychopharmacology. 2018 Apr;43(5):1138-1145. doi: 10.1038/npp.2017.290. Epub 2017 Nov 28.


Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone.

Enuka Y, Feldman ME, Chowdhury A, Srivastava S, Lindzen M, Sas-Chen A, Massart R, Cheishvili D, Suderman MJ, Zaltsman Y, Mazza CA, Shukla K, Körner C, Furth N, Lauriola M, Oren M, Wiemann S, Szyf M, Yarden Y.

Nucleic Acids Res. 2017 Dec 15;45(22):12681-12699. doi: 10.1093/nar/gkx865.


Prenatal Glucocorticoid Exposure Modifies Endocrine Function and Behaviour for 3 Generations Following Maternal and Paternal Transmission.

Moisiadis VG, Constantinof A, Kostaki A, Szyf M, Matthews SG.

Sci Rep. 2017 Sep 18;7(1):11814. doi: 10.1038/s41598-017-11635-w.


Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness.

Gouin JP, Zhou QQ, Booij L, Boivin M, Côté SM, Hébert M, Ouellet-Morin I, Szyf M, Tremblay RE, Turecki G, Vitaro F.

Sci Rep. 2017 Aug 7;7(1):7446. doi: 10.1038/s41598-017-07950-x.

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