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Molecular dynamics analysis of Mg2+ -dependent cleavage of a pistol ribozyme reveals a fail-safe secondary ion for catalysis.

Joseph NN, Roy RN, Steitz TA.

J Comput Chem. 2020 Feb 24. doi: 10.1002/jcc.26179. [Epub ahead of print]


Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P, Liu X.

J Med Chem. 2019 Feb 14;62(3):1484-1501. doi: 10.1021/acs.jmedchem.8b01656. Epub 2019 Jan 18.


Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation.

Lomakin IB, Dmitriev SE, Steitz TA.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):528-533. doi: 10.1073/pnas.1809688116. Epub 2018 Dec 24.


Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.

Yang Y, Kang D, Nguyen LA, Smithline ZB, Pannecouque C, Zhan P, Liu X, Steitz TA.

Elife. 2018 Jul 25;7. pii: e36340. doi: 10.7554/eLife.36340.


Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.

Lin J, Zhou D, Steitz TA, Polikanov YS, Gagnon MG.

Annu Rev Biochem. 2018 Jun 20;87:451-478. doi: 10.1146/annurev-biochem-062917-011942. Epub 2018 Mar 23. Review.


Structural basis of bacterial transcription activation.

Liu B, Hong C, Huang RK, Yu Z, Steitz TA.

Science. 2017 Nov 17;358(6365):947-951. doi: 10.1126/science.aao1923.


Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation.

Vaidya AT, Lomakin IB, Joseph NN, Dmitriev SE, Steitz TA.

J Mol Biol. 2017 Sep 1;429(18):2765-2771. doi: 10.1016/j.jmb.2017.07.015. Epub 2017 Jul 21.


Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.

Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA.

Cell Rep. 2017 Jul 18;20(3):521-528. doi: 10.1016/j.celrep.2017.06.025.


Perspectives on the ribosome.

Steitz TA, Moore PB.

Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160537. doi: 10.1098/rstb.2016.0537. No abstract available.


Crystal structure of Pistol, a class of self-cleaving ribozyme.

Nguyen LA, Wang J, Steitz TA.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1021-1026. doi: 10.1073/pnas.1611191114. Epub 2017 Jan 17.


Structural insights into NusG regulating transcription elongation.

Liu B, Steitz TA.

Nucleic Acids Res. 2017 Jan 25;45(2):968-974. doi: 10.1093/nar/gkw1159. Epub 2016 Nov 29.


A structure-based kinetic model of transcription.

Zuo Y, Steitz TA.

Transcription. 2017 Jan;8(1):1-8. doi: 10.1080/21541264.2016.1234821. Epub 2016 Sep 22.


Elongation factor 4 remodels the A-site tRNA on the ribosome.

Gagnon MG, Lin J, Steitz TA.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4994-9. doi: 10.1073/pnas.1522932113. Epub 2016 Apr 18.


Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.

Melnikov SV, Söll D, Steitz TA, Polikanov YS.

Nucleic Acids Res. 2016 Jun 2;44(10):4978-87. doi: 10.1093/nar/gkw246. Epub 2016 Apr 13.


Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism.

Liu B, Zuo Y, Steitz TA.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4051-6. doi: 10.1073/pnas.1520555113. Epub 2016 Mar 28.


Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.

Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA.

Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. doi: 10.1093/nar/gkw018. Epub 2016 Jan 24.


Antimicrobial peptides targeting bacterial ribosome.

Lomakin IB, Gagnon MG, Steitz TA.

Oncotarget. 2015 Aug 7;6(22):18744-5. No abstract available.


Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN.

Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28.


The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin.

Roy RN, Lomakin IB, Gagnon MG, Steitz TA.

Nat Struct Mol Biol. 2015 Jun;22(6):466-9. doi: 10.1038/nsmb.3031. Epub 2015 May 18.


Crystal structures of the E. coli transcription initiation complexes with a complete bubble.

Zuo Y, Steitz TA.

Mol Cell. 2015 May 7;58(3):534-40. doi: 10.1016/j.molcel.2015.03.010. Epub 2015 Apr 9.

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