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DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads.

Macdonald J, Kilcoyne KR, Sharpe RM, Kavanagh Á, Anderson RA, Brown P, Smith LB, Jørgensen A, Mitchell RT.

Hum Reprod. 2018 Sep 29. doi: 10.1093/humrep/dey289. [Epub ahead of print]


Fetal life shapes adult male reproductive function.

Sharpe RM.

Lancet Child Adolesc Health. 2018 Oct;2(10):695-696. doi: 10.1016/S2352-4642(18)30276-1. Epub 2018 Aug 30. No abstract available.


Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems.

Hurtado-Gonzalez P, Anderson RA, Macdonald J, van den Driesche S, Kilcoyne K, Jørgensen A, McKinnell C, Macpherson S, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.


Of mice and men: long-term safety of assisted reproduction treatments.

Sharpe RM.

Hum Reprod. 2018 May 1;33(5):793-796. doi: 10.1093/humrep/dey071. No abstract available.


'Man Up': the importance and strategy for placing male reproductive health centre stage in the political and research agenda.

Barratt CLR, De Jonge CJ, Sharpe RM.

Hum Reprod. 2018 Apr 1;33(4):541-545. doi: 10.1093/humrep/dey020.


Programmed for sex: Nutrition-reproduction relationships from an inter-generational perspective.

Sharpe RM.

Reproduction. 2018 Feb;155(3):S1-S16. doi: 10.1530/REP-17-0537. Epub 2017 Dec 21. Review.


Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics.

Patel SH, O'Hara L, Atanassova N, Smith SE, Curley MK, Rebourcet D, Darbey AL, Gannon AL, Sharpe RM, Smith LB.

Sci Rep. 2017 Aug 21;7(1):8991. doi: 10.1038/s41598-017-09016-4.


Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.

Lara NLM, Driesche SVD, Macpherson S, França LR, Sharpe RM.

Sci Rep. 2017 May 31;7(1):2521. doi: 10.1038/s41598-017-02684-2.


Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.

Ribaroff GA, Wastnedge E, Drake AJ, Sharpe RM, Chambers TJG.

Obes Rev. 2017 Jun;18(6):673-686. doi: 10.1111/obr.12524. Epub 2017 Mar 30. Review.


Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window.

van den Driesche S, Kilcoyne KR, Wagner I, Rebourcet D, Boyle A, Mitchell R, McKinnell C, Macpherson S, Donat R, Shukla CJ, Jorgensen A, Meyts ER, Skakkebaek NE, Sharpe RM.

JCI Insight. 2017 Mar 23;2(6):e91204. doi: 10.1172/jci.insight.91204.


Timing of Maternal Exposure and Foetal Sex Determine the Effects of Low-level Chemical Mixture Exposure on the Foetal Neuroendocrine System in Sheep.

Bellingham M, Fowler PA, MacDonald ES, Mandon-Pepin B, Cotinot C, Rhind S, Sharpe RM, Evans NP.

J Neuroendocrinol. 2016 Dec;28(12). doi: 10.1111/jne.12444.


High-fat diet disrupts metabolism in two generations of rats in a parent-of-origin specific manner.

Chambers TJ, Morgan MD, Heger AH, Sharpe RM, Drake AJ.

Sci Rep. 2016 Aug 23;6:31857. doi: 10.1038/srep31857.


CisSERS: Customizable In Silico Sequence Evaluation for Restriction Sites.

Sharpe RM, Koepke T, Harper A, Grimes J, Galli M, Satoh-Cruz M, Kalyanaraman A, Evans K, Kramer D, Dhingra A.

PLoS One. 2016 Apr 12;11(4):e0152404. doi: 10.1371/journal.pone.0152404. eCollection 2016.


Dealing with phthalates in medical devices: a case of primum non nocere (first do no harm)?

Tasker RC, Sharpe RM.

Intensive Care Med. 2016 Apr;42(4):602-604. doi: 10.1007/s00134-016-4227-5. Epub 2016 Feb 3. No abstract available.


Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.

Dean A, van den Driesche S, Wang Y, McKinnell C, Macpherson S, Eddie SL, Kinnell H, Hurtado-Gonzalez P, Chambers TJ, Stevenson K, Wolfinger E, Hrabalkova L, Calarrao A, Bayne RA, Hagen CP, Mitchell RT, Anderson RA, Sharpe RM.

Sci Rep. 2016 Jan 27;6:19789. doi: 10.1038/srep19789.


Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure.

Le Moal J, Sharpe RM, Jϕrgensen N, Levine H, Jurewicz J, Mendiola J, Swan SH, Virtanen H, Christin-Maître S, Cordier S, Toppari J, Hanke W; HURGENT Network.

Eur J Public Health. 2016 Feb;26(1):76-83. doi: 10.1093/eurpub/ckv153. Epub 2015 Sep 1.


The war on error.

Evers JL, Sharpe RM, Somigliana E, Williams AC.

Hum Reprod. 2015 Aug;30(8):1747-8. doi: 10.1093/humrep/dev146. Epub 2015 Jun 24. No abstract available.


Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.

van den Driesche S, Macdonald J, Anderson RA, Johnston ZC, Chetty T, Smith LB, Mckinnell C, Dean A, Homer NZ, Jorgensen A, Camacho-Moll ME, Sharpe RM, Mitchell RT.

Sci Transl Med. 2015 May 20;7(288):288ra80. doi: 10.1126/scitranslmed.aaa4097.


Developmental and Subcellular Organization of Single-Cell C₄ Photosynthesis in Bienertia sinuspersici Determined by Large-Scale Proteomics and cDNA Assembly from 454 DNA Sequencing.

Offermann S, Friso G, Doroshenk KA, Sun Q, Sharpe RM, Okita TW, Wimmer D, Edwards GE, van Wijk KJ.

J Proteome Res. 2015 May 1;14(5):2090-108. doi: 10.1021/pr5011907. Epub 2015 Apr 9.


Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts.

van den Driesche S, McKinnell C, Calarrão A, Kennedy L, Hutchison GR, Hrabalkova L, Jobling MS, Macpherson S, Anderson RA, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2015 Mar;123(3):223-30. doi: 10.1289/ehp.1408248. Epub 2014 Dec 16.

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