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Items: 1 to 20 of 36

1.

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.

Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S.

Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192.

PMID:
26351917
2.

Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels.

Rathkolb B, Klempt M, Sabrautzki S, Michel D, Klaften M, Laufs J, Sedlmeier R, Hans W, Fuchs H, Muckenthaler MU, Horsch M, Campagna DR, Fleming M, Hrabé de Angelis M, Wolf E, Aigner B.

Biometals. 2015 Apr;28(2):293-306. doi: 10.1007/s10534-015-9824-1. Epub 2015 Jan 31.

PMID:
25636453
3.

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration.

Becker A, Kohlmann S, Alexandru A, Jagla W, Canneva F, Bäuscher C, Cynis H, Sedlmeier R, Graubner S, Schilling S, Demuth HU, von Hörsten S.

BMC Neurosci. 2013 Oct 1;14:108. doi: 10.1186/1471-2202-14-108.

4.

Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development.

Chen D, Li S, Singh R, Spinette S, Sedlmeier R, Epstein HF.

J Cell Sci. 2012 Aug 15;125(Pt 16):3893-903. doi: 10.1242/jcs.106435. Epub 2012 May 2.

5.

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S.

J Neurosci. 2011 Sep 7;31(36):12790-801. doi: 10.1523/JNEUROSCI.1794-11.2011.

6.

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU.

EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20.

7.

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.

Aigner B, Rathkolb B, Klempt M, Wagner S, Michel D, Klaften M, Laufs J, Schneider B, Sedlmeier R, Hrabé de Angelis M, Wolf E.

Mamm Genome. 2011 Oct;22(9-10):495-505. doi: 10.1007/s00335-011-9328-4. Epub 2011 May 8.

PMID:
21553221
8.

Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.

Oschatz C, Maas C, Lecher B, Jansen T, Björkqvist J, Tradler T, Sedlmeier R, Burfeind P, Cichon S, Hammerschmidt S, Müller-Esterl W, Wuillemin WA, Nilsson G, Renné T.

Immunity. 2011 Feb 25;34(2):258-68. doi: 10.1016/j.immuni.2011.02.008.

9.

Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.

Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU.

J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17.

10.

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models.

Aigner B, Rathkolb B, Klaften M, Sedlmeier R, Klempt M, Wagner S, Michel D, Mayer U, Klopstock T, de Angelis MH, Wolf E.

Exp Physiol. 2009 Apr;94(4):412-21. doi: 10.1113/expphysiol.2008.045864. Epub 2009 Jan 16.

11.

Absence of arterial phenotype in mice with homozygous slc2A10 missense substitutions.

Callewaert BL, Loeys BL, Casteleyn C, Willaert A, Dewint P, De Backer J, Sedlmeier R, Simoens P, De Paepe AM, Coucke PJ.

Genesis. 2008 Aug;46(8):385-9. doi: 10.1002/dvg.20409.

PMID:
18693279
12.

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.

Dobler T, Springauf A, Tovornik S, Weber M, Schmitt A, Sedlmeier R, Wischmeyer E, Döring F.

J Physiol. 2007 Dec 15;585(Pt 3):867-79. Epub 2007 Oct 25.

13.

Use of an exon-trapping vector for the evaluation of splice-site mutations.

Schneider B, Koppius A, Sedlmeier R.

Mamm Genome. 2007 Sep;18(9):670-6. Epub 2007 Aug 9.

PMID:
17687606
14.

Current methods for high-throughput detection of novel DNA polymorphisms.

Peters T, Sedlmeier R.

Drug Discov Today Technol. 2006 Summer;3(2):123-9. doi: 10.1016/j.ddtec.2006.05.002.

PMID:
24980398
15.

N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.

Grosse J, Tarnow P, Römpler H, Schneider B, Sedlmeier R, Huffstadt U, Korthaus D, Nehls M, Wattler S, Schöneberg T, Biebermann H, Augustin M.

Physiol Genomics. 2006 Aug 16;26(3):209-17. Epub 2006 May 23.

16.

Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD.

Münch C, Rosenbohm A, Sperfeld AD, Uttner I, Reske S, Krause BJ, Sedlmeier R, Meyer T, Hanemann CO, Stumm G, Ludolph AC.

Ann Neurol. 2005 Nov;58(5):777-80.

PMID:
16240349
17.

Efficient and fast targeted production of murine models based on ENU mutagenesis.

Augustin M, Sedlmeier R, Peters T, Huffstadt U, Kochmann E, Simon D, Schöniger M, Garke-Mayerthaler S, Laufs J, Mayhaus M, Franke S, Klose M, Graupner A, Kurzmann M, Zinser C, Wolf A, Voelkel M, Kellner M, Kilian M, Seelig S, Koppius A, Teubner A, Korthaus D, Nehls M, Wattler S.

Mamm Genome. 2005 Jun;16(6):405-13.

PMID:
16075367
18.

Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS.

Münch C, Sedlmeier R, Meyer T, Homberg V, Sperfeld AD, Kurt A, Prudlo J, Peraus G, Hanemann CO, Stumm G, Ludolph AC.

Neurology. 2004 Aug 24;63(4):724-6.

PMID:
15326253
19.

Alopecia in a novel mouse model RCO3 is caused by mK6irs1 deficiency.

Peters T, Sedlmeier R, Büssow H, Runkel F, Lüers GH, Korthaus D, Fuchs H, Hrabé de Angelis M, Stumm G, Russ AP, Porter RM, Augustin M, Franz T.

J Invest Dermatol. 2003 Oct;121(4):674-80.

20.

A mouse model for cystinuria type I.

Peters T, Thaete C, Wolf S, Popp A, Sedlmeier R, Grosse J, Nehls MC, Russ A, Schlueter V.

Hum Mol Genet. 2003 Sep 1;12(17):2109-20.

PMID:
12923163

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