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Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases.

Zhang D, Burdette BE, Wang Z, Karn K, Li HY, Schramm VL, Tyler PC, Evans GB, Wang S.

Biochemistry. 2020 Feb 25;59(7):831-835. doi: 10.1021/acs.biochem.9b01092. Epub 2020 Feb 11.


Enhanced Antibiotic Discovery by PROSPECTing.

Schramm VL, Meek TD.

Biochemistry. 2019 Aug 20;58(33):3475-3476. doi: 10.1021/acs.biochem.9b00616. Epub 2019 Aug 9. No abstract available.


Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.

Joshi S, Fedoseyenko D, Mahanta N, Ducati RG, Feng M, Schramm VL, Begley TP.

ACS Med Chem Lett. 2019 Feb 15;10(3):363-366. doi: 10.1021/acsmedchemlett.8b00649. eCollection 2019 Mar 14.


Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.

Harijan RK, Hoff O, Ducati RG, Firestone RS, Hirsch BM, Evans GB, Schramm VL, Tyler PC.

J Med Chem. 2019 Apr 11;62(7):3286-3296. doi: 10.1021/acs.jmedchem.8b01642. Epub 2019 Mar 28.


The transition to magic bullets - transition state analogue drug design.

Evans GB, Schramm VL, Tyler PC.

Medchemcomm. 2018 Aug 28;9(12):1983-1993. doi: 10.1039/c8md00372f. eCollection 2018 Dec 1. Review.


Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase.

Ducati RG, Harijan RK, Cameron SA, Tyler PC, Evans GB, Schramm VL.

ACS Chem Biol. 2018 Nov 16;13(11):3173-3183. doi: 10.1021/acschembio.8b00781. Epub 2018 Oct 19.


Enzymatic Transition States and Drug Design.

Schramm VL.

Chem Rev. 2018 Nov 28;118(22):11194-11258. doi: 10.1021/acs.chemrev.8b00369. Epub 2018 Oct 18. Review.


Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.

Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6209-E6216. doi: 10.1073/pnas.1805416115. Epub 2018 Jun 18.


Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence.

Schramm VL, Schwartz SD.

Biochemistry. 2018 Jun 19;57(24):3299-3308. doi: 10.1021/acs.biochem.8b00201. Epub 2018 Apr 10. Review.


Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum.

Ducati RG, Namanja-Magliano HA, Harijan RK, Fajardo JE, Fiser A, Daily JP, Schramm VL.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2114-2119. doi: 10.1073/pnas.1525670115. Epub 2018 Feb 12.


Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.

Harris LD, Harijan RK, Ducati RG, Evans GB, Hirsch BM, Schramm VL.

ACS Chem Biol. 2018 Jan 19;13(1):152-160. doi: 10.1021/acschembio.7b00601. Epub 2017 Dec 14.


Immucillins in Infectious Diseases.

Evans GB, Tyler PC, Schramm VL.

ACS Infect Dis. 2018 Feb 9;4(2):107-117. doi: 10.1021/acsinfecdis.7b00172. Epub 2017 Dec 5. Review.


Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum.

Ducati RG, Firestone RS, Schramm VL.

Biochemistry. 2017 Dec 5;56(48):6368-6376. doi: 10.1021/acs.biochem.7b01027. Epub 2017 Nov 21.


Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions.

Stratton CF, Poulin MB, Schramm VL.

Methods Enzymol. 2017;596:1-21. doi: 10.1016/bs.mie.2017.07.019. Epub 2017 Aug 31.


The Transition-State Structure for Human MAT2A from Isotope Effects.

Firestone RS, Schramm VL.

J Am Chem Soc. 2017 Oct 4;139(39):13754-13760. doi: 10.1021/jacs.7b05803. Epub 2017 Sep 20.


Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.

Moggré GJ, Poulin MB, Tyler PC, Schramm VL, Parker EJ.

ACS Chem Biol. 2017 Oct 20;12(10):2662-2670. doi: 10.1021/acschembio.7b00484. Epub 2017 Sep 19.


Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.

Namanja-Magliano HA, Evans GB, Harijan RK, Tyler PC, Schramm VL.

Biochemistry. 2017 Sep 26;56(38):5090-5098. doi: 10.1021/acs.biochem.7b00576. Epub 2017 Sep 7.


Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase.

Gebre ST, Cameron SA, Li L, Babu YS, Schramm VL.

J Biol Chem. 2017 Sep 22;292(38):15907-15915. doi: 10.1074/jbc.M117.801779. Epub 2017 Aug 9.


Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase.

Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6456-6461. doi: 10.1073/pnas.1704786114. Epub 2017 Jun 5.


Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase.

Firestone RS, Cameron SA, Karp JM, Arcus VL, Schramm VL.

ACS Chem Biol. 2017 Feb 17;12(2):464-473. doi: 10.1021/acschembio.6b00885. Epub 2016 Dec 27.

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