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Items: 1 to 20 of 151


Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.

Lin Z, Phadke S, Lu Z, Beyhan S, Abdel Aziz MH, Reilly C, Schmidt EW.

J Nat Prod. 2018 Dec 3. doi: 10.1021/acs.jnatprod.7b01067. [Epub ahead of print]


Roads to Rome: Role of Multiple Cassettes in Cyanobactin RiPP Biosynthesis.

Gu W, Sardar D, Pierce E, Schmidt EW.

J Am Chem Soc. 2018 Nov 28;140(47):16213-16221. doi: 10.1021/jacs.8b09328. Epub 2018 Nov 14.


A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases.

Estrada P, Morita M, Hao Y, Schmidt EW, Nair SK.

J Am Chem Soc. 2018 Jul 5;140(26):8124-8127. doi: 10.1021/jacs.8b05187. Epub 2018 Jun 26.


Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene.

Wozniak CE, Lin Z, Schmidt EW, Hughes KT, Liou TG.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00463-18. doi: 10.1128/AAC.00463-18. Print 2018 Sep.


The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis.

Gu W, Dong SH, Sarkar S, Nair SK, Schmidt EW.

Methods Enzymol. 2018;604:113-163. doi: 10.1016/bs.mie.2018.03.002. Epub 2018 May 4.


Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis.

Morita M, Hao Y, Jokela JK, Sardar D, Lin Z, Sivonen K, Nair SK, Schmidt EW.

J Am Chem Soc. 2018 May 16;140(19):6044-6048. doi: 10.1021/jacs.8b03137. Epub 2018 May 1.


Parallel lives of symbionts and hosts: chemical mutualism in marine animals.

Morita M, Schmidt EW.

Nat Prod Rep. 2018 Apr 25;35(4):357-378. doi: 10.1039/c7np00053g. Review.


Accessing chemical diversity from the uncultivated symbionts of small marine animals.

Smith TE, Pond CD, Pierce E, Harmer ZP, Kwan J, Zachariah MM, Harper MK, Wyche TP, Matainaho TK, Bugni TS, Barrows LR, Ireland CM, Schmidt EW.

Nat Chem Biol. 2018 Feb;14(2):179-185. doi: 10.1038/nchembio.2537. Epub 2018 Jan 1.


Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts.

Torres JP, Tianero MD, Robes JMD, Kwan JC, Biggs JS, Concepcion GP, Olivera BM, Haygood MG, Schmidt EW.

Appl Environ Microbiol. 2017 Nov 16;83(23). pii: e01418-17. doi: 10.1128/AEM.01418-17. Print 2017 Dec 1.


Three Principles of Diversity-Generating Biosynthesis.

Gu W, Schmidt EW.

Acc Chem Res. 2017 Oct 17;50(10):2569-2576. doi: 10.1021/acs.accounts.7b00330. Epub 2017 Sep 11.


Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products.

Lin Z, Smith MD, Concepcion GP, Haygood MG, Olivera BM, Light A, Schmidt EW.

J Nat Prod. 2017 Aug 25;80(8):2360-2370. doi: 10.1021/acs.jnatprod.7b00317. Epub 2017 Jul 26.


Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.

Olivera BM, Raghuraman S, Schmidt EW, Safavi-Hemami H.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Sep;203(9):717-735. doi: 10.1007/s00359-017-1183-7. Epub 2017 May 27. Review.


Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory.

Distel DL, Altamia MA, Lin Z, Shipway JR, Han A, Forteza I, Antemano R, Limbaco MGJP, Tebo AG, Dechavez R, Albano J, Rosenberg G, Concepcion GP, Schmidt EW, Haygood MG.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3652-E3658. doi: 10.1073/pnas.1620470114. Epub 2017 Apr 17.


Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges.

Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS.

Nat Chem Biol. 2017 May;13(5):537-543. doi: 10.1038/nchembio.2330. Epub 2017 Mar 20.


Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products.

Sardar D, Hao Y, Lin Z, Morita M, Nair SK, Schmidt EW.

J Am Chem Soc. 2017 Mar 1;139(8):2884-2887. doi: 10.1021/jacs.6b12872. Epub 2017 Feb 15.


Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis.

Zhang S, Qiu Y, Kakule TB, Lu Z, Xu F, Lamb JG, Reilly CA, Zheng Y, Sham SW, Wang W, Xuan L, Schmidt EW, Zhan J.

J Nat Prod. 2017 Feb 24;80(2):363-370. doi: 10.1021/acs.jnatprod.6b00808. Epub 2017 Jan 20.


Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.

Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE 3rd, Schmidt EW, Nair SK.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14037-14042. Epub 2016 Nov 21.


Directing Biosynthesis: Practical Supply of Natural and Unnatural Cyanobactins.

Sardar D, Tianero MD, Schmidt EW.

Methods Enzymol. 2016;575:1-20. doi: 10.1016/bs.mie.2016.02.012. Epub 2016 Mar 16.


Origin of Chemical Diversity in Prochloron-Tunicate Symbiosis.

Lin Z, Torres JP, Tianero MD, Kwan JC, Schmidt EW.

Appl Environ Microbiol. 2016 May 31;82(12):3450-60. doi: 10.1128/AEM.00860-16. Print 2016 Jun 15.


Metabolic model for diversity-generating biosynthesis.

Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE, Schmidt EW.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1772-7. doi: 10.1073/pnas.1525438113. Epub 2016 Feb 1.

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