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Items: 1 to 20 of 157

1.

Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination.

Stifter K, Schuster C, Krieger J, Spyrantis A, Boehm BO, Schirmbeck R.

Mol Ther Methods Clin Dev. 2018 Dec 13;12:123-133. doi: 10.1016/j.omtm.2018.12.002. eCollection 2019 Mar 15.

2.

Impaired immune surveillance accelerates accumulation of senescent cells and aging.

Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V.

Nat Commun. 2018 Dec 21;9(1):5435. doi: 10.1038/s41467-018-07825-3.

3.

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion.

Tharehalli U, Svinarenko M, Kraus JM, Kühlwein SD, Szekely R, Kiesle U, Scheffold A, Barth TFE, Kleger A, Schirmbeck R, Kestler HA, Seufferlein T, Oswald F, Katz SF, Lechel A.

Int J Mol Sci. 2018 Nov 29;19(12). pii: E3801. doi: 10.3390/ijms19123801.

4.

Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids.

Cwiklowska K, Westhoff MA, Freisinger S, Dwucet A, Halatsch ME, Knippschild U, Debatin KM, Schirmbeck R, Winiarski L, Oleksyszyn J, Wirtz CR, Burster T.

Oncol Lett. 2018 Nov;16(5):6181-6187. doi: 10.3892/ol.2018.9347. Epub 2018 Aug 21.

5.
6.

Aged murine hematopoietic stem cells drive aging-associated immune remodeling.

Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R.

Blood. 2018 Aug 9;132(6):565-576. doi: 10.1182/blood-2018-02-831065. Epub 2018 Jun 11.

PMID:
29891535
7.

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.

8.

Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.

Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.

PMID:
28414328
9.

High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers.

Hettich M, Braun F, Bartholomä MD, Schirmbeck R, Niedermann G.

Theranostics. 2016 Jun 18;6(10):1629-40. doi: 10.7150/thno.15253. eCollection 2016.

10.

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.

Stifter K, Schuster C, Schlosser M, Boehm BO, Schirmbeck R.

Sci Rep. 2016 Jul 11;6:29419. doi: 10.1038/srep29419.

11.

Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen.

Real CI, Lu M, Liu J, Huang X, Trippler M, Hossbach M, Deckert J, Jahn-Hofmann K, Ickenstein LM, John MJ, Gibbert K, Dittmer U, Vornlocher HP, Schirmbeck R, Gerken G, Schlaak JF, Broering R.

Sci Rep. 2016 Apr 28;6:24865. doi: 10.1038/srep24865.

12.

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M.

Hepatology. 2016 May;63(5):1592-607. doi: 10.1002/hep.28435. Epub 2016 Mar 4.

13.

HSC Aging and Senescent Immune Remodeling.

Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H.

Trends Immunol. 2015 Dec;36(12):815-824. doi: 10.1016/j.it.2015.10.008. Epub 2015 Nov 21. Review.

14.

Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes.

Ochel A, Cebula M, Riehn M, Hillebrand U, Lipps C, Schirmbeck R, Hauser H, Wirth D.

Cell Mol Immunol. 2016 Nov;13(6):805-815. doi: 10.1038/cmi.2015.80. Epub 2015 Oct 12.

15.

Minicircle: Next Generation DNA Vectors for Vaccination.

Schleef M, Schirmbeck R, Reiser M, Michel ML, Schmeer M.

Methods Mol Biol. 2015;1317:327-39. doi: 10.1007/978-1-4939-2727-2_18.

PMID:
26072415
16.

Hematopoietic stem cell aging.

Geiger H, Denkinger M, Schirmbeck R.

Curr Opin Immunol. 2014 Aug;29:86-92. doi: 10.1016/j.coi.2014.05.002. Epub 2014 Jun 3. Review.

PMID:
24905894
17.

Differential presentation of endogenous and exogenous hepatitis B surface antigens influences priming of CD8(+) T cells in an epitope-specific manner.

Riedl P, Reiser M, Stifter K, Krieger J, Schirmbeck R.

Eur J Immunol. 2014 Jul;44(7):1981-91. doi: 10.1002/eji.201343933. Epub 2014 May 11.

18.

Long-term IKK2/NF-κB signaling in pancreatic β-cells induces immune-mediated diabetes.

Salem HH, Trojanowski B, Fiedler K, Maier HJ, Schirmbeck R, Wagner M, Boehm BO, Wirth T, Baumann B.

Diabetes. 2014 Mar;63(3):960-75. doi: 10.2337/db13-1037. Epub 2013 Dec 2.

19.

A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.

Schuster C, Brosi H, Stifter K, Boehm BO, Schirmbeck R.

PLoS One. 2013 Aug 19;8(8):e71746. doi: 10.1371/journal.pone.0071746. eCollection 2013.

20.

An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells.

Cebula M, Ochel A, Hillebrand U, Pils MC, Schirmbeck R, Hauser H, Wirth D.

PLoS One. 2013 Jul 15;8(7):e68720. doi: 10.1371/journal.pone.0068720. Print 2013.

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