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Coordinating a new approach to basic research into Parkinson's disease.

Schekman R, Riley EA.

Elife. 2019 Sep 25;8. pii: e51167. doi: 10.7554/eLife.51167.


New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.

Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J.

J Cell Biol. 2019 Nov 4;218(11):3861-3879. doi: 10.1083/jcb.201902028. Epub 2019 Sep 5.


Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes.

Temoche-Diaz MM, Shurtleff MJ, Nottingham RM, Yao J, Fadadu RP, Lambowitz AM, Schekman R.

Elife. 2019 Aug 22;8. pii: e47544. doi: 10.7554/eLife.47544.


Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex.

Brier LW, Ge L, Stjepanovic G, Thelen AM, Hurley JH, Schekman R.

Mol Biol Cell. 2019 Apr 15;30(9):1098-1107. doi: 10.1091/mbc.E18-11-0743. Epub 2019 Feb 27.


Progress and promise.

Schekman R.

Elife. 2019 Jan 23;8. pii: e44799. doi: 10.7554/eLife.44799.


TANGO1 and SEC12 are copackaged with procollagen I to facilitate the generation of large COPII carriers.

Yuan L, Kenny SJ, Hemmati J, Xu K, Schekman R.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12255-E12264. doi: 10.1073/pnas.1814810115. Epub 2018 Dec 13.


Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.

Melville D, Gorur A, Schekman R.

Mol Biol Cell. 2019 Feb 1;30(3):387-399. doi: 10.1091/mbc.E18-09-0548. Epub 2018 Nov 28.


A new twist on peer review.

Patterson M, Schekman R.

Elife. 2018 Jun 26;7. pii: e36545. doi: 10.7554/eLife.36545.


A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network.

Ma T, Li B, Wang R, Lau PK, Huang Y, Jiang L, Schekman R, Guo Y.

J Biol Chem. 2018 Jun 1;293(22):8410-8427. doi: 10.1074/jbc.RA118.001906. Epub 2018 Apr 17.


How early-career researchers are shaping eLife.

Patterson M, Schekman R.

Elife. 2018 Mar 27;7. pii: e36263. doi: 10.7554/eLife.36263.


Transparency in authors' contributions and responsibilities to promote integrity in scientific publication.

McNutt MK, Bradford M, Drazen JM, Hanson B, Howard B, Jamieson KH, Kiermer V, Marcus E, Pope BK, Schekman R, Swaminathan S, Stang PJ, Verma IM.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2557-2560. doi: 10.1073/pnas.1715374115. Epub 2018 Feb 27.


Cell-free Generation of COPII-coated Procollagen I Carriers.

Yuan L, Baba S, Bajaj K, Schekman R.

Bio Protoc. 2017 Nov 20;7(22). pii: e2450. doi: 10.21769/BioProtoc.2450.


Unconventional secretion of FABP4 by endosomes and secretory lysosomes.

Villeneuve J, Bassaganyas L, Lepreux S, Chiritoiu M, Costet P, Ripoche J, Malhotra V, Schekman R.

J Cell Biol. 2018 Feb 5;217(2):649-665. doi: 10.1083/jcb.201705047. Epub 2017 Dec 6.


Broad role for YBX1 in defining the small noncoding RNA composition of exosomes.

Shurtleff MJ, Yao J, Qin Y, Nottingham RM, Temoche-Diaz MM, Schekman R, Lambowitz AM.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8987-E8995. doi: 10.1073/pnas.1712108114. Epub 2017 Oct 10.


Room at the top.

Schekman R.

Elife. 2017 Oct 12;6. pii: e31697. doi: 10.7554/eLife.31697.


Introduction: The Challenge to Science in the Arena of Public Policy.

Schekman R.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:v-vii. doi: 10.1146/annurev-cb-33-092017-100001. No abstract available.


TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.

Hanna MG 4th, Block S, Frankel EB, Hou F, Johnson A, Yuan L, Knight G, Moresco JJ, Yates JR 3rd, Ashton R, Schekman R, Tong Y, Audhya A.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7707-E7716. doi: 10.1073/pnas.1709120114. Epub 2017 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2017 Sep 25;:.


Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.

Sirkis DW, Aparicio RE, Schekman R.

Mol Biol Cell. 2017 Oct 1;28(20):2723-2733. doi: 10.1091/mbc.E17-06-0423. Epub 2017 Aug 2.


Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis.

Ge L, Zhang M, Kenny SJ, Liu D, Maeda M, Saito K, Mathur A, Xu K, Schekman R.

EMBO Rep. 2017 Sep;18(9):1586-1603. doi: 10.15252/embr.201744559. Epub 2017 Jul 28.


COPII-coated membranes function as transport carriers of intracellular procollagen I.

Gorur A, Yuan L, Kenny SJ, Baba S, Xu K, Schekman R.

J Cell Biol. 2017 Jun 5;216(6):1745-1759. doi: 10.1083/jcb.201702135. Epub 2017 Apr 20.

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