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Items: 1 to 20 of 24

1.

Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.

Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H.

Mol Psychiatry. 2018 Feb 9. doi: 10.1038/s41380-017-0011-3. [Epub ahead of print]

PMID:
29426955
2.

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model.

Berghoff SA, Düking T, Spieth L, Winchenbach J, Stumpf SK, Gerndt N, Kusch K, Ruhwedel T, Möbius W, Saher G.

Acta Neuropathol Commun. 2017 Dec 1;5(1):94. doi: 10.1186/s40478-017-0497-6.

3.

Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice.

Winchenbach J, Düking T, Berghoff SA, Stumpf SK, Hülsmann S, Nave KA, Saher G.

F1000Res. 2016 Dec 30;5:2934. doi: 10.12688/f1000research.10509.1. eCollection 2016.

4.

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.

Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G.

Nat Commun. 2017 Jan 24;8:14241. doi: 10.1038/ncomms14241.

5.

Cholesterol in myelin biogenesis and hypomyelinating disorders.

Saher G, Stumpf SK.

Biochim Biophys Acta. 2015 Aug;1851(8):1083-94. doi: 10.1016/j.bbalip.2015.02.010. Epub 2015 Feb 24. Review.

PMID:
25724171
6.

Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H.

Mol Psychiatry. 2014 Oct;19(10):1143-9. doi: 10.1038/mp.2013.110. Epub 2013 Sep 3.

PMID:
23999527
7.

Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment.

Paul D, Hoppe S, Saher G, Krijnse-Locker J, Bartenschlager R.

J Virol. 2013 Oct;87(19):10612-27. doi: 10.1128/JVI.01370-13. Epub 2013 Jul 24.

8.

A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.

Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA.

Glia. 2013 Apr;61(4):567-86. doi: 10.1002/glia.22456. Epub 2013 Jan 16.

PMID:
23322581
9.

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.

Saher G, Rudolphi F, Corthals K, Ruhwedel T, Schmidt KF, Löwel S, Dibaj P, Barrette B, Möbius W, Nave KA.

Nat Med. 2012 Jul;18(7):1130-5. doi: 10.1038/nm.2833.

PMID:
22706386
10.

Critical time window of neuronal cholesterol synthesis during neurite outgrowth.

Fünfschilling U, Jockusch WJ, Sivakumar N, Möbius W, Corthals K, Li S, Quintes S, Kim Y, Schaap IA, Rhee JS, Nave KA, Saher G.

J Neurosci. 2012 May 30;32(22):7632-45. doi: 10.1523/JNEUROSCI.1352-11.2012.

11.

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.

Kassmann CM, Quintes S, Rietdorf J, Möbius W, Sereda MW, Nientiedt T, Saher G, Baes M, Nave KA.

FEBS Lett. 2011 Jul 21;585(14):2205-11. doi: 10.1016/j.febslet.2011.05.032. Epub 2011 May 23.

12.

Cholesterol: a novel regulatory role in myelin formation.

Saher G, Quintes S, Nave KA.

Neuroscientist. 2011 Feb;17(1):79-93. doi: 10.1177/1073858410373835.

PMID:
21343408
13.

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models.

Chrast R, Saher G, Nave KA, Verheijen MH.

J Lipid Res. 2011 Mar;52(3):419-34. doi: 10.1194/jlr.R009761. Epub 2010 Nov 9. Review.

14.

Neuron-glia signaling and the protection of axon function by Schwann cells.

Quintes S, Goebbels S, Saher G, Schwab MH, Nave KA.

J Peripher Nerv Syst. 2010 Mar;15(1):10-6. doi: 10.1111/j.1529-8027.2010.00247.x. Review.

PMID:
20433601
15.

Cholesterol and myelin biogenesis.

Saher G, Simons M.

Subcell Biochem. 2010;51:489-508. doi: 10.1007/978-90-481-8622-8_18. Review.

PMID:
20213556
16.

Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.

Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA.

J Neurosci. 2009 May 13;29(19):6094-104. doi: 10.1523/JNEUROSCI.0686-09.2009.

17.

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.

Saito K, Dubreuil V, Arai Y, Wilsch-Bräuninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8350-5. doi: 10.1073/pnas.0903541106. Epub 2009 May 5.

18.

Survival of adult neurons lacking cholesterol synthesis in vivo.

Fünfschilling U, Saher G, Xiao L, Möbius W, Nave KA.

BMC Neurosci. 2007 Jan 2;8:1.

19.

High cholesterol level is essential for myelin membrane growth.

Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA.

Nat Neurosci. 2005 Apr;8(4):468-75. Epub 2005 Mar 27.

PMID:
15793579
20.

The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice.

Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH.

EMBO J. 2002 Feb 15;21(4):525-35.

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