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Items: 1 to 20 of 32


Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation.

Rodgers JT, Davydova NY, Paragas EM, Jones JP, Davydov DR.

Biochem Pharmacol. 2018 Oct;156:86-98. doi: 10.1016/j.bcp.2018.08.010. Epub 2018 Aug 13.


mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.

Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H.

Cell Stem Cell. 2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008.


Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences.

Davydov DR, Davydova NY, Rodgers JT, Rushmore TH, Jones JP.

Biochem J. 2017 Oct 10;474(20):3523-3542. doi: 10.1042/BCJ20170543.


HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into GAlert.

Rodgers JT, Schroeder MD, Ma C, Rando TA.

Cell Rep. 2017 Apr 18;19(3):479-486. doi: 10.1016/j.celrep.2017.03.066.


Deteriorating Infrastructure in the Aged Muscle Stem Cell Niche.

Rodgers JT.

Cell Stem Cell. 2016 Aug 4;19(2):150-151. doi: 10.1016/j.stem.2016.07.008.


mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).

Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA.

Nature. 2014 Jun 19;510(7505):393-6. doi: 10.1038/nature13255. Epub 2014 May 25.


Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.

Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198.


USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy.

Hall JA, Tabata M, Rodgers JT, Puigserver P.

Mol Endocrinol. 2014 Jun;28(6):912-24. doi: 10.1210/me.2013-1420. Epub 2014 Apr 2.


Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex.

Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P.

Diabetes. 2014 May;63(5):1519-32. doi: 10.2337/db13-1304. Epub 2014 Jan 23.


Healthcare navigation service in 2-1-1 San Diego: guiding individuals to the care they need.

Rodgers JT, Purnell JQ.

Am J Prev Med. 2012 Dec;43(6 Suppl 5):S450-6. doi: 10.1016/j.amepre.2012.08.012.


Sprouting a new take on stem cell aging.

Rodgers JT, Rando TA.

EMBO J. 2012 Nov 5;31(21):4103-5. doi: 10.1038/emboj.2012.281. Epub 2012 Oct 5. No abstract available.


Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.

Rodgers JT, Vogel RO, Puigserver P.

Mol Cell. 2011 Feb 18;41(4):471-9. doi: 10.1016/j.molcel.2011.02.007.


Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.


Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.

Rodgers JT, Haas W, Gygi SP, Puigserver P.

Cell Metab. 2010 Jan;11(1):23-34. doi: 10.1016/j.cmet.2009.11.006.


Foxo1 integrates insulin signaling with mitochondrial function in the liver.

Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF.

Nat Med. 2009 Nov;15(11):1307-11. doi: 10.1038/nm.2049. Epub 2009 Oct 18.


Insulin resistance: beta-arrestin development.

Rodgers JT, Puigserver P.

Cell Res. 2009 Mar;19(3):275-6. doi: 10.1038/cr.2009.22. No abstract available.


A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose.

Housley MP, Udeshi ND, Rodgers JT, Shabanowitz J, Puigserver P, Hunt DF, Hart GW.

J Biol Chem. 2009 Feb 20;284(8):5148-57. doi: 10.1074/jbc.M808890200. Epub 2008 Dec 22.


O-GlcNAc regulates FoxO activation in response to glucose.

Housley MP, Rodgers JT, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P, Hart GW.

J Biol Chem. 2008 Jun 13;283(24):16283-92. doi: 10.1074/jbc.M802240200. Epub 2008 Apr 17.


mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P.

Nature. 2007 Nov 29;450(7170):736-40.


Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.

Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P.

FEBS Lett. 2008 Jan 9;582(1):46-53. Epub 2007 Nov 26. Review.

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