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Items: 1 to 20 of 106


Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells.

Soustek MS, Balsa E, Barrow JJ, Jedrychowski M, Vogel R, Jan Smeitink, Gygi SP, Puigserver P.

Cell Death Dis. 2018 May 31;9(6):658. doi: 10.1038/s41419-018-0696-5.


Insulin regulation of gluconeogenesis.

Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P.

Ann N Y Acad Sci. 2018 Jan;1411(1):21-35. doi: 10.1111/nyas.13435. Epub 2017 Sep 3. Review.


PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors.

Luo C, Widlund HR, Puigserver P.

Trends Cancer. 2016 Oct;2(10):619-631. doi: 10.1016/j.trecan.2016.09.006. Review.


ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-Elevated Melanomas.

Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P.

Mol Cancer Res. 2017 Oct;15(10):1366-1375. doi: 10.1158/1541-7786.MCR-17-0143. Epub 2017 Jun 8.


Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P.

Cell. 2017 Mar 23;169(1):148-160.e15. doi: 10.1016/j.cell.2017.03.001.


Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.

Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS.

Nature. 2017 Mar 9;543(7644):252-256. doi: 10.1038/nature21379. Epub 2017 Feb 20.


Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.

Hatting M, Rines AK, Luo C, Tabata M, Sharabi K, Hall JA, Verdeguer F, Trautwein C, Puigserver P.

Cell Metab. 2017 Feb 7;25(2):428-437. doi: 10.1016/j.cmet.2016.12.007. Epub 2017 Jan 12.


Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.

Rines AK, Sharabi K, Tavares CD, Puigserver P.

Nat Rev Drug Discov. 2016 Nov;15(11):786-804. doi: 10.1038/nrd.2016.151. Epub 2016 Aug 12. Review.


Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.

Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR 4th, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P.

Mol Cell. 2016 Oct 6;64(1):163-175. doi: 10.1016/j.molcel.2016.08.023. Epub 2016 Sep 22.


A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.

Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P.

Nature. 2016 Sep 15;537(7620):422-426. doi: 10.1038/nature19347. Epub 2016 Aug 31.


Breaking BRAF(V600E)-drug resistance by stressing mitochondria.

Luo C, Puigserver P, Widlund HR.

Pigment Cell Melanoma Res. 2016 Jul;29(4):401-3. doi: 10.1111/pcmr.12486. No abstract available.


The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.

Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P.

J Biol Chem. 2016 May 13;291(20):10635-45. doi: 10.1074/jbc.M115.706200. Epub 2016 Mar 28.


Stem cells: Dietary fat promotes intestinal dysregulation.

Luo C, Puigserver P.

Nature. 2016 Mar 3;531(7592):42-3. doi: 10.1038/531042a. No abstract available.


Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation.

Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH.

Sci Rep. 2016 Jan 7;6:18928. doi: 10.1038/srep18928.


Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth.

Balsa-Martinez E, Puigserver P.

Mol Cell. 2015 Nov 19;60(4):509-11. doi: 10.1016/j.molcel.2015.11.005.


Molecular pathophysiology of hepatic glucose production.

Sharabi K, Tavares CD, Rines AK, Puigserver P.

Mol Aspects Med. 2015 Dec;46:21-33. doi: 10.1016/j.mam.2015.09.003. Epub 2015 Nov 5. Review.


Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity.

Verdeguer F, Soustek MS, Hatting M, Blättler SM, McDonald D, Barrow JJ, Puigserver P.

Mol Cell Biol. 2015 Oct 26;36(1):184-96. doi: 10.1128/MCB.00722-15.


Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity.

Soustek MS, Puigserver P.

EMBO J. 2015 Apr 15;34(8):981-3. doi: 10.15252/embj.201591240. Epub 2015 Mar 3.


Adenosine activates thermogenic adipocytes.

Rines AK, Verdeguer F, Puigserver P.

Cell Res. 2015 Feb;25(2):155-6. doi: 10.1038/cr.2014.157. Epub 2014 Dec 2.


Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P.

Nature. 2014 Jun 26;510(7506):547-51. doi: 10.1038/nature13267. Epub 2014 May 25.

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