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Items: 1 to 20 of 246

1.

A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.

Antoniou N, Vlachakis D, Memou A, Leandrou E, Valkimadi PE, Melachroinou K, Re DB, Przedborski S, Dauer WT, Stefanis L, Rideout HJ.

Sci Rep. 2018 Feb 22;8(1):3455. doi: 10.1038/s41598-018-21931-8.

2.

Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons.

Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS.

J Clin Invest. 2018 Feb 1;128(2):774-788. doi: 10.1172/JCI95795. Epub 2018 Jan 16.

3.

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.

Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, Marras C, Tanner CM, Ross GW, Langston JW, Klein C, Bonifati V, Jankovic J, Lozano AM, Deuschl G, Bergman H, Tolosa E, Rodriguez-Violante M, Fahn S, Postuma RB, Berg D, Marek K, Standaert DG, Surmeier DJ, Olanow CW, Kordower JH, Calabresi P, Schapira AHV, Stoessl AJ.

Mov Disord. 2017 Sep;32(9):1264-1310. doi: 10.1002/mds.27115. Review.

4.

The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form.

Liu Y, Guardia-Laguarta C, Yin J, Erdjument-Bromage H, Martin B, James M, Jiang X, Przedborski S.

Cell Rep. 2017 Jul 5;20(1):30-39. doi: 10.1016/j.celrep.2017.06.022.

5.

The two-century journey of Parkinson disease research.

Przedborski S.

Nat Rev Neurosci. 2017 Mar 17;18(4):251-259. doi: 10.1038/nrn.2017.25. Review.

PMID:
28303016
6.

Axonal Degeneration: RIPK1 Multitasking in ALS.

Politi K, Przedborski S.

Curr Biol. 2016 Oct 24;26(20):R932-R934. doi: 10.1016/j.cub.2016.08.052.

7.

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.

Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, Yoshikawa K.

Nat Commun. 2016 Mar 14;7:10943. doi: 10.1038/ncomms10943.

8.

Identification of neurodegenerative factors using translatome-regulatory network analysis.

Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P.

Nat Neurosci. 2015 Sep;18(9):1325-33. doi: 10.1038/nn.4070. Epub 2015 Jul 27.

9.

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis.

Ikiz B, Alvarez MJ, Ré DB, Le Verche V, Politi K, Lotti F, Phani S, Pradhan R, Yu C, Croft GF, Jacquier A, Henderson CE, Califano A, Przedborski S.

Cell Rep. 2015 Jul 14;12(2):335-45. doi: 10.1016/j.celrep.2015.06.019. Epub 2015 Jul 2.

10.

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.

Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG.

Lancet Neurol. 2015 Aug;14(8):855-866. doi: 10.1016/S1474-4422(15)00006-X. Epub 2015 Jun 3. Review.

11.

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.

Guardia-Laguarta C, Area-Gomez E, Schon EA, Przedborski S.

Mov Disord. 2015 Jul;30(8):1026-33. doi: 10.1002/mds.26239. Epub 2015 May 7. Review.

PMID:
25952565
12.

α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.

Kett LR, Stiller B, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Zhou B, Di Paolo G, Przedborski S, Cuervo AM, Dauer WT.

J Neurosci. 2015 Apr 8;35(14):5724-42. doi: 10.1523/JNEUROSCI.0632-14.2015.

13.

Novel subcellular localization for α-synuclein: possible functional consequences.

Guardia-Laguarta C, Area-Gomez E, Schon EA, Przedborski S.

Front Neuroanat. 2015 Feb 23;9:17. doi: 10.3389/fnana.2015.00017. eCollection 2015. Review.

14.

Parkinson's disease: animal models and dopaminergic cell vulnerability.

Blesa J, Przedborski S.

Front Neuroanat. 2014 Dec 15;8:155. doi: 10.3389/fnana.2014.00155. eCollection 2014. Review.

15.

A computational model of motor neuron degeneration.

Le Masson G, Przedborski S, Abbott LF.

Neuron. 2014 Aug 20;83(4):975-88. doi: 10.1016/j.neuron.2014.07.001. Epub 2014 Jul 31. Erratum in: Neuron. 2014 Aug 20;83(4):990.

16.

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S.

Neuron. 2014 Mar 5;81(5):1001-1008. doi: 10.1016/j.neuron.2014.01.011. Epub 2014 Feb 6.

17.

α-Synuclein is localized to mitochondria-associated ER membranes.

Guardia-Laguarta C, Area-Gomez E, Rüb C, Liu Y, Magrané J, Becker D, Voos W, Schon EA, Przedborski S.

J Neurosci. 2014 Jan 1;34(1):249-59. doi: 10.1523/JNEUROSCI.2507-13.2014.

18.

Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy.

Fedorowicz MA, de Vries-Schneider RL, Rüb C, Becker D, Huang Y, Zhou C, Alessi Wolken DM, Voos W, Liu Y, Przedborski S.

EMBO Rep. 2014 Jan;15(1):86-93. doi: 10.1002/embr.201337294. Epub 2013 Dec 15.

19.

Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes.

Roybon L, Lamas NJ, Garcia AD, Yang EJ, Sattler R, Lewis VJ, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE.

Cell Rep. 2013 Sep 12;4(5):1035-1048. doi: 10.1016/j.celrep.2013.06.021. Epub 2013 Aug 29.

20.

Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis.

Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, van den Berg LH, Ringel S.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14 Suppl 1:5-18. doi: 10.3109/21678421.2013.778548.

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