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Items: 1 to 20 of 194

1.

Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.

Fillebeen C, Charlebois E, Wagner J, Katsarou A, Mui J, Vali H, Garcia-Santos D, Ponka P, Presley J, Pantopoulos K.

Blood. 2019 Jan 24;133(4):344-355. doi: 10.1182/blood-2018-05-850404. Epub 2018 Dec 11.

PMID:
30538134
2.

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model.

Garcia-Santos D, Hamdi A, Saxova Z, Fillebeen C, Pantopoulos K, Horvathova M, Ponka P.

Blood. 2018 Jan 11;131(2):236-246. doi: 10.1182/blood-2017-07-798728. Epub 2017 Nov 27.

3.

The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.

Laroque A, Min-Oo G, Tam M, Ponka P, Stevenson MM, Gros P.

PLoS One. 2017 May 18;12(5):e0177818. doi: 10.1371/journal.pone.0177818. eCollection 2017.

4.

Extracellular glycine is necessary for optimal hemoglobinization of erythroid cells.

Garcia-Santos D, Schranzhofer M, Bergeron R, Sheftel AD, Ponka P.

Haematologica. 2017 Aug;102(8):1314-1323. doi: 10.3324/haematol.2016.155671. Epub 2017 May 11.

5.

Do Mammalian Cells Really Need to Export and Import Heme?

Ponka P, Sheftel AD, English AM, Scott Bohle D, Garcia-Santos D.

Trends Biochem Sci. 2017 May;42(5):395-406. doi: 10.1016/j.tibs.2017.01.006. Epub 2017 Feb 20. Review.

PMID:
28254242
6.

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

Li H, Choesang T, Bao W, Chen H, Feola M, Garcia-Santos D, Li J, Sun S, Follenzi A, Pham P, Liu J, Zhang J, Ponka P, An X, Mohandas N, Fleming RE, Rivella S, Li G, Ginzburg YZ.

Blood. 2017 Mar 16;129(11):1514-1526. doi: 10.1182/blood-2016-09-742387. Epub 2017 Feb 1. Erratum in: Blood. 2017 Dec 21;130(25):2809.

7.

Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.

Hamdi A, Roshan TM, Kahawita TM, Mason AB, Sheftel AD, Ponka P.

Biochim Biophys Acta. 2016 Dec;1863(12):2859-2867. doi: 10.1016/j.bbamcr.2016.09.008. Epub 2016 Sep 11.

8.

Response to: Dietary and pharmacological factors affecting iron absorption in mice and man.

Fillebeen C, Gkouvatsos K, Fragoso G, Calvé A, Garcia-Santos D, Buffler M, Becker C, Schümann K, Ponka P, Santos MM, Pantopoulos K.

Haematologica. 2016 Mar;101(3):e122. doi: 10.3324/haematol.2015.139741. No abstract available.

9.

Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation.

Fillebeen C, Gkouvatsos K, Fragoso G, Calvé A, Garcia-Santos D, Buffler M, Becker C, Schümann K, Ponka P, Santos MM, Pantopoulos K.

Haematologica. 2015 Sep;100(9):e334-7. doi: 10.3324/haematol.2015.126870. Epub 2015 May 14. No abstract available.

10.

Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.

Gasiorek JJ, Mikhael M, Garcia-Santos D, Hui ST, Ponka P, Blank V.

Exp Hematol. 2015 May;43(5):393-403.e2. doi: 10.1016/j.exphem.2015.01.003. Epub 2015 Jan 16.

PMID:
25600403
11.

Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme.

Garcia-Santos D, Schranzhofer M, Horvathova M, Jaberi MM, Bogo Chies JA, Sheftel AD, Ponka P.

Blood. 2014 Apr 3;123(14):2269-77. doi: 10.1182/blood-2013-04-496760. Epub 2014 Feb 7.

12.

Hepcidin bound to α2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels.

Huang ML, Austin CJ, Sari MA, Rahmanto YS, Ponka P, Vyoral D, Richardson DR.

J Biol Chem. 2013 Aug 30;288(35):25450-65. doi: 10.1074/jbc.M113.471573. Epub 2013 Jul 11.

13.

Snx3 regulates recycling of the transferrin receptor and iron assimilation.

Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH.

Cell Metab. 2013 Mar 5;17(3):343-52. doi: 10.1016/j.cmet.2013.01.013. Epub 2013 Feb 14.

14.

Nitrogen monoxide inhibits haem synthesis in mouse reticulocytes.

Mikhael MR, Roshan T, Soe-Lin S, Apte S, Ponka P.

Biochem J. 2013 Apr 1;451(1):61-7. doi: 10.1042/BJ20121649. Erratum in: Biochem J. 2014 Sep 15;462(3):603. Roshan, Tariq [added].

PMID:
23363555
15.

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia.

Whitnall M, Suryo Rahmanto Y, Huang ML, Saletta F, Lok HC, Gutiérrez L, Lázaro FJ, Fleming AJ, St Pierre TG, Mikhael MR, Ponka P, Richardson DR.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20590-5. doi: 10.1073/pnas.1215349109. Epub 2012 Nov 20.

16.

Iron overload in human disease.

Fleming RE, Ponka P.

N Engl J Med. 2012 Jan 26;366(4):348-59. doi: 10.1056/NEJMra1004967. Review. No abstract available. Erratum in: N Engl J Med. 2012 Feb 23;366(8):771.

PMID:
22276824
17.

Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes.

Lok HC, Suryo Rahmanto Y, Hawkins CL, Kalinowski DS, Morrow CS, Townsend AJ, Ponka P, Richardson DR.

J Biol Chem. 2012 Jan 2;287(1):607-18. doi: 10.1074/jbc.M111.310987. Epub 2011 Nov 14.

18.

The long history of iron in the Universe and in health and disease.

Sheftel AD, Mason AB, Ponka P.

Biochim Biophys Acta. 2012 Mar;1820(3):161-87. doi: 10.1016/j.bbagen.2011.08.002. Epub 2011 Aug 9. Review.

19.

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

Lovejoy DB, Jansson PJ, Brunk UT, Wong J, Ponka P, Richardson DR.

Cancer Res. 2011 Sep 1;71(17):5871-80. doi: 10.1158/0008-5472.CAN-11-1218. Epub 2011 Jul 12.

20.

Hypoxia. 5. Hypoxia and hematopoiesis.

Yoon D, Ponka P, Prchal JT.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1215-22. doi: 10.1152/ajpcell.00044.2011. Epub 2011 Mar 2. Review.

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