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Sex and age differences in the association between sympathetic outflow and central elastic artery wall thickness in humans.

Holwerda SW, Luehrs RE, DuBose LE, Majee R, Pierce GL.

Am J Physiol Heart Circ Physiol. 2019 Jul 5. doi: 10.1152/ajpheart.00275.2019. [Epub ahead of print]


Response by Holwerda et al to Letter Regarding Article "Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults".

Holwerda SW, Fadel PJ, Abboud FM, Pierce GL.

Hypertension. 2019 Aug;74(2):e33. doi: 10.1161/HYPERTENSIONAHA.119.13299. Epub 2019 Jun 24. No abstract available.


Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension.

Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD.

Hypertension. 2019 Jul;74(1):173-183. doi: 10.1161/HYPERTENSIONAHA.119.13101. Epub 2019 May 20.


Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults.

Holwerda SW, Luehrs RE, DuBose L, Collins MT, Wooldridge NA, Stroud AK, Fadel PJ, Abboud FM, Pierce GL.

Hypertension. 2019 May;73(5):1025-1035. doi: 10.1161/HYPERTENSIONAHA.118.12462. Erratum in: Hypertension. 2019 Jun;73(6):e122.


CT-Measured Lung Air-Trapping is Associated with Higher Carotid Artery Stiffness in Individuals with Chronic Obstructive Pulmonary Disease.

Luehrs RE, Newell JD Jr, Comellas AP, Hoffman EA, Warner K, Croghan A, DuBose LE, Nopoulos P, Magnotta V, Arndt S, Pierce GL, Hoth KF.

J Appl Physiol (1985). 2018 Oct 11. doi: 10.1152/japplphysiol.00580.2018. [Epub ahead of print]


Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice.

Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL.

JCI Insight. 2018 Oct 4;3(19). pii: 99403. doi: 10.1172/jci.insight.99403.


Higher Aortic Stiffness Is Associated With Lower Global Cerebrovascular Reserve Among Older Humans.

DuBose LE, Boles Ponto LL, Moser DJ, Harlynn E, Reierson L, Pierce GL.

Hypertension. 2018 Aug;72(2):476-482. doi: 10.1161/HYPERTENSIONAHA.118.11143. Epub 2018 Jun 18.


Initiating life-long aerobic exercise 4-5 days per week before or near age 50 years: is this the 'holy-grail' of preventing age-related central artery stiffness?

Pierce GL.

J Physiol. 2018 Jul;596(14):2635-2636. doi: 10.1113/JP276253. Epub 2018 Jun 21. No abstract available.


Femoral vascular conductance and peroneal muscle sympathetic nerve activity responses to acute epidural spinal cord stimulation in humans.

Holwerda SW, Holland MT, Reddy CG, Pierce GL.

Exp Physiol. 2018 Jun;103(6):905-915. doi: 10.1113/EP086945. Epub 2018 May 5.


Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety.

Holwerda SW, Luehrs RE, Gremaud AL, Wooldridge NA, Stroud AK, Fiedorowicz JG, Abboud FM, Pierce GL.

J Neurophysiol. 2018 Jul 1;120(1):11-22. doi: 10.1152/jn.00064.2018. Epub 2018 Mar 14.


Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia.

Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK.

Clin Sci (Lond). 2018 Feb 14;132(3):419-436. doi: 10.1042/CS20171059. Print 2018 Feb 14.


Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin.

Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL.

Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R770-R780. doi: 10.1152/ajpregu.00435.2017. Epub 2018 Jan 24.


Bipolar disorder and related mood states are not associated with endothelial function of small arteries in adults without heart disease.

Tong B, Abosi O, Schmitz S, Myers J, Pierce GL, Fiedorowicz JG.

Gen Hosp Psychiatry. 2018 Mar - Apr;51:36-40. doi: 10.1016/j.genhosppsych.2017.12.005. Epub 2017 Dec 19.


Hemoglobin A1c and C-reactive protein are independently associated with blunted nocturnal blood pressure dipping in obesity-related prediabetes.

Lane-Cordova AD, Kalil GZ, Wagner CJ, Sindler AL, Fiedorowicz JG, Ajibewa T, Haynes WG, Pierce GL.

Hypertens Res. 2018 Jan;41(1):33-38. doi: 10.1038/hr.2017.82. Epub 2017 Oct 26.


Aortic Stiffness in Aging and Hypertension: Prevention and Treatment with Habitual Aerobic Exercise.

Pierce GL.

Curr Hypertens Rep. 2017 Oct 18;19(11):90. doi: 10.1007/s11906-017-0788-0. Review.


Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function.

Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ.

Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H890-H895. doi: 10.1152/ajpheart.00416.2017. Epub 2017 Sep 29.


Mechanisms and Subclinical Consequences of Aortic Stiffness.

Pierce GL.

Hypertension. 2017 Nov;70(5):848-853. doi: 10.1161/HYPERTENSIONAHA.117.08933. Epub 2017 Sep 5. Review. No abstract available.


Muscle contraction induced arterial shear stress increases endothelial nitric oxide synthase phosphorylation in humans.

Casey DP, Ueda K, Wegman-Points L, Pierce GL.

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H854-H859. doi: 10.1152/ajpheart.00282.2017. Epub 2017 Aug 11.


The Acute Effects of Aerobic Exercise on the Functional Connectivity of Human Brain Networks.

Weng TB, Pierce GL, Darling WG, Falk D, Magnotta VA, Voss MW.

Brain Plast. 2017 Mar 28;2(2):171-190. doi: 10.3233/BPL-160039.


Carotid β-stiffness index is associated with slower processing speed but not working memory or white matter integrity in healthy middle-aged/older adults.

DuBose LE, Voss MW, Weng TB, Kent JD, Dubishar KM, Lane-Cordova A, Sigurdsson G, Schmid P, Barlow PB, Pierce GL.

J Appl Physiol (1985). 2017 Apr 1;122(4):868-876. doi: 10.1152/japplphysiol.00769.2016. Epub 2017 Jan 26.

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