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Items: 1 to 20 of 23

1.

Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome.

Lucas M, Deshpande P, James I, Rauch A, Pfafferott K, Gaylard E, Merani S, Plauzolles A, Lucas A, McDonnell W, Kalams S, Pilkinton M, Chastain C, Barnett L, Prosser A, Mallal S, Fitzmaurice K, Drummer H, Ansari MA, Pedergnana V, Barnes E, John M, Kelleher D, Klenerman P, Gaudieri S.

Sci Rep. 2018 May 8;8(1):7224. doi: 10.1038/s41598-018-25559-6.

2.

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection.

Adland E, Hill M, Lavandier N, Csala A, Edwards A, Chen F, Radkowski M, Kowalska JD, Paraskevis D, Hatzakis A, Valenzuela-Ponce H, Pfafferott K, Williams I, Pellegrino P, Borrow P, Mori M, Rockstroh J, Prado JG, Mothe B, Dalmau J, Martinez-Picado J, Tudor-Williams G, Frater J, Stryhn A, Buus S, Teran GR, Mallal S, John M, Buchbinder S, Kirk G, Martin J, Michael N, Fellay J, Deeks S, Walker B, Avila-Rios S, Cole D, Brander C, Carrington M, Goulder P.

J Virol. 2018 Jan 30;92(4). pii: e01685-17. doi: 10.1128/JVI.01685-17. Print 2018 Feb 15.

3.

Influence of Transmitted Virus on the Host's Immune Response: A Case Study.

Merani S, Lucas M, Deshpande P, Pfafferott K, Chopra A, Cooper D, Leary S, Luciani F, Gaudieri S.

Viral Immunol. 2017 Sep;30(7):533-541. doi: 10.1089/vim.2017.0001. Epub 2017 May 22.

PMID:
28530508
4.

Anti-hepatitis C virus T-cell immunity in the context of multiple exposures to the virus.

Pfafferott K, Deshpande P, McKinnon E, Merani S, Lucas A, Heckerman D, Mallal S, John M, Gaudieri S, Lucas M.

PLoS One. 2015 Jun 24;10(6):e0130420. doi: 10.1371/journal.pone.0130420. eCollection 2015.

5.

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.

von Delft A, Humphreys IS, Brown A, Pfafferott K, Lucas M, Klenerman P, Lauer GM, Cox AL, Gaudieri S, Barnes E.

Gut. 2016 Jan;65(1):112-23. doi: 10.1136/gutjnl-2014-308724. Epub 2015 Jun 19.

6.

Relative resistance of HIV-1 founder viruses to control by interferon-alpha.

Fenton-May AE, Dibben O, Emmerich T, Ding H, Pfafferott K, Aasa-Chapman MM, Pellegrino P, Williams I, Cohen MS, Gao F, Shaw GM, Hahn BH, Ochsenbauer C, Kappes JC, Borrow P.

Retrovirology. 2013 Dec 3;10:146. doi: 10.1186/1742-4690-10-146.

7.

Molecular mechanisms of HIV type 1 prophylaxis failure revealed by single-genome sequencing.

Li H, Blair L, Chen Y, Learn G, Pfafferott K, John M, Bhattacharya T, Hahn BH, Mallal S, Shaw GM, Bar KJ.

J Infect Dis. 2013 Nov 15;208(10):1598-603. doi: 10.1093/infdis/jit485. Epub 2013 Sep 9.

8.

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease.

Desmond CP, Gaudieri S, James IR, Pfafferott K, Chopra A, Lau GK, Audsley J, Day C, Chivers S, Gordon A, Revill PA, Bowden S, Ayres A, Desmond PV, Thompson AJ, Roberts SK, Locarnini SA, Mallal SA, Lewin SR.

J Virol. 2012 Jan;86(2):1181-92. doi: 10.1128/JVI.05308-11. Epub 2011 Nov 9.

9.

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.

Pfafferott K, Gaudieri S, Ulsenheimer A, James I, Heeg M, Nolan D, John M, Rauch A, Mallal S, Lucas A, Klenerman P, Diepolder HM, Lucas M.

PLoS One. 2011 Feb 8;6(2):e16797. doi: 10.1371/journal.pone.0016797.

10.

Full-length characterization of hepatitis C virus subtype 3a reveals novel hypervariable regions under positive selection during acute infection.

Humphreys I, Fleming V, Fabris P, Parker J, Schulenberg B, Brown A, Demetriou C, Gaudieri S, Pfafferott K, Lucas M, Collier J, Huang KH, Pybus OG, Klenerman P, Barnes E.

J Virol. 2009 Nov;83(22):11456-66. doi: 10.1128/JVI.00884-09. Epub 2009 Sep 9. Erratum in: J Virol. 2010 Feb;84(3):1664.

11.

Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure.

Rauch A, James I, Pfafferott K, Nolan D, Klenerman P, Cheng W, Mollison L, McCaughan G, Shackel N, Jeffrey GP, Baker R, Freitas E, Humphreys I, Furrer H, G√ľnthard HF, Hirschel B, Mallal S, John M, Lucas M, Barnes E, Gaudieri S.

Hepatology. 2009 Oct;50(4):1017-29. doi: 10.1002/hep.23101.

PMID:
19670417
12.

Automation of the ELISpot assay for high-throughput detection of antigen-specific T-cell responses.

Almeida CA, Roberts SG, Laird R, McKinnon E, Ahmed I, Pfafferott K, Turley J, Keane NM, Lucas A, Rushton B, Chopra A, Mallal S, John M.

J Immunol Methods. 2009 May 15;344(1):1-5. doi: 10.1016/j.jim.2009.02.007. Epub 2009 Mar 10.

13.

Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy.

Gaudieri S, Rauch A, Pfafferott K, Barnes E, Cheng W, McCaughan G, Shackel N, Jeffrey GP, Mollison L, Baker R, Furrer H, G√ľnthard HF, Freitas E, Humphreys I, Klenerman P, Mallal S, James I, Roberts S, Nolan D, Lucas M.

Hepatology. 2009 Apr;49(4):1069-82. doi: 10.1002/hep.22773.

PMID:
19263475
14.

Adaptation of HIV-1 to human leukocyte antigen class I.

Kawashima Y, Pfafferott K, Frater J, Matthews P, Payne R, Addo M, Gatanaga H, Fujiwara M, Hachiya A, Koizumi H, Kuse N, Oka S, Duda A, Prendergast A, Crawford H, Leslie A, Brumme Z, Brumme C, Allen T, Brander C, Kaslow R, Tang J, Hunter E, Allen S, Mulenga J, Branch S, Roach T, John M, Mallal S, Ogwu A, Shapiro R, Prado JG, Fidler S, Weber J, Pybus OG, Klenerman P, Ndung'u T, Phillips R, Heckerman D, Harrigan PR, Walker BD, Takiguchi M, Goulder P.

Nature. 2009 Apr 2;458(7238):641-5. doi: 10.1038/nature07746. Epub 2009 Feb 25.

15.

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.

Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen TM, Rosenberg ES, Kiepiela P, Vajpayee M, Goepfert PA, Altfeld M, Goulder PJ, Walker BD.

J Virol. 2007 Feb;81(4):1619-31. Epub 2006 Nov 22.

16.

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection.

Gaudieri S, Rauch A, Park LP, Freitas E, Herrmann S, Jeffrey G, Cheng W, Pfafferott K, Naidoo K, Chapman R, Battegay M, Weber R, Telenti A, Furrer H, James I, Lucas M, Mallal SA.

J Virol. 2006 Nov;80(22):11094-104. Erratum in: J Virol. 2007 Aug;81(16):8846-8.

17.

Passive sexual transmission of human immunodeficiency virus type 1 variants and adaptation in new hosts.

Frater AJ, Edwards CT, McCarthy N, Fox J, Brown H, Milicic A, Mackie N, Pillay T, Drijfhout JW, Dustan S, Clarke JR, Holmes EC, Zhang HT, Pfafferott K, Goulder PJ, McClure MO, Weber J, Phillips RE, Fidler S.

J Virol. 2006 Jul;80(14):7226-34.

18.

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Martinez-Picado J, Prado JG, Fry EE, Pfafferott K, Leslie A, Chetty S, Thobakgale C, Honeyborne I, Crawford H, Matthews P, Pillay T, Rousseau C, Mullins JI, Brander C, Walker BD, Stuart DI, Kiepiela P, Goulder P.

J Virol. 2006 Apr;80(7):3617-23.

19.

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.

Pillay T, Zhang HT, Drijfhout JW, Robinson N, Brown H, Khan M, Moodley J, Adhikari M, Pfafferott K, Feeney ME, St John A, Holmes EC, Coovadia HM, Klenerman P, Goulder PJ, Phillips RE.

J Virol. 2005 Sep;79(18):12100-5.

20.

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.

Feeney ME, Tang Y, Pfafferott K, Roosevelt KA, Draenert R, Trocha A, Yu XG, Verrill C, Allen T, Moore C, Mallal S, Burchett S, McIntosh K, Pelton SI, St John MA, Hazra R, Klenerman P, Altfeld M, Walker BD, Goulder PJ.

J Immunol. 2005 Jun 15;174(12):7524-30.

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