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An extended structure-activity relationship of non-dioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors.

Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler HJ, Pessah IN.

Toxicol Sci. 2016 Sep 21. pii: kfw189. [Epub ahead of print]


Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ.

Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137.


In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide.

Ronjat M, Feng W, Dardevet L, Dong Y, Al Khoury S, Chatelain FC, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2460-8. doi: 10.1073/pnas.1517342113. Epub 2016 Apr 11.


Detection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay.

Ahn KC, Ranganathan A, Bever CS, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ.

Environ Sci Technol. 2016 Apr 5;50(7):3754-61. doi: 10.1021/acs.est.5b05357. Epub 2016 Mar 18.


Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.

Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ.

Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14.


Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.

Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN.

Mol Pharmacol. 2015 Apr;87(4):595-605. doi: 10.1124/mol.114.096701. Epub 2015 Jan 12.


Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA.

Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN.

Aquat Toxicol. 2015 Feb;159:156-66. doi: 10.1016/j.aquatox.2014.12.017. Epub 2014 Dec 19.


The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.

Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H.

Neurotherapeutics. 2015 Jan;12(1):234-49. doi: 10.1007/s13311-014-0305-y.


Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome.

Berman RF, Buijsen RA, Usdin K, Pintado E, Kooy F, Pretto D, Pessah IN, Nelson DL, Zalewski Z, Charlet-Bergeurand N, Willemsen R, Hukema RK.

J Neurodev Disord. 2014;6(1):25. doi: 10.1186/1866-1955-6-25. Epub 2014 Jul 30. Review.


Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle.

Altamirano F, Eltit JM, Robin G, Linares N, Ding X, Pessah IN, Allen PD, López JR.

J Biol Chem. 2014 Jul 4;289(27):19180-90. doi: 10.1074/jbc.M114.550764. Epub 2014 May 20.


Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity.

Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN.

Mol Pharmacol. 2014 Apr;85(4):630-9. doi: 10.1124/mol.113.090076. Epub 2014 Jan 30.


PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms.

Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ.

Toxicol Sci. 2014 Apr;138(2):379-92. doi: 10.1093/toxsci/kft334. Epub 2014 Jan 2.


Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.

Pretto DI, Kumar M, Cao Z, Cunningham CL, Durbin-Johnson B, Qi L, Berman R, Noctor SC, Hagerman RJ, Pessah IN, Tassone F.

Neurobiol Aging. 2014 May;35(5):1189-97. doi: 10.1016/j.neurobiolaging.2013.11.009. Epub 2013 Nov 16.


Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction.

Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler HJ, Pessah IN.

Toxicol Sci. 2013 Dec;136(2):500-13. doi: 10.1093/toxsci/kft202. Epub 2013 Sep 7.


Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation.

Vogel CF, Wu D, Goth SR, Baek J, Lollies A, Domhardt R, Grindel A, Pessah IN.

Immunol Cell Biol. 2013 Oct;91(9):568-75. doi: 10.1038/icb.2013.43. Epub 2013 Sep 3.


Autism-specific maternal autoantibodies recognize critical proteins in developing brain.

Braunschweig D, Krakowiak P, Duncanson P, Boyce R, Hansen RL, Ashwood P, Hertz-Picciotto I, Pessah IN, Van de Water J.

Transl Psychiatry. 2013 Jul 9;3:e277. doi: 10.1038/tp.2013.50.


Structure-activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss).

Fritsch EB, Pessah IN.

Aquat Toxicol. 2013 Sep 15;140-141:204-12. doi: 10.1016/j.aquatox.2013.06.003. Epub 2013 Jun 14.


Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism.

Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ.

Biol Psychiatry. 2013 Aug 1;74(3):204-11. doi: 10.1016/j.biopsych.2013.03.006. Epub 2013 Apr 25.


Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion.

Cao Z, Hulsizer S, Cui Y, Pretto DL, Kim KH, Hagerman PJ, Tassone F, Pessah IN.

J Biol Chem. 2013 May 10;288(19):13831-41. doi: 10.1074/jbc.M112.441055. Epub 2013 Apr 3.

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