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Spotlight on vitamin D receptor, lipid metabolism and mitochondria: Some preliminary emerging issues.

Silvagno F, Pescarmona G.

Mol Cell Endocrinol. 2017 Jul 15;450:24-31. doi: 10.1016/j.mce.2017.04.013. Epub 2017 Apr 13. Review.


Mitochondrial and lipogenic effects of vitamin D on differentiating and proliferating human keratinocytes.

Consiglio M, Viano M, Casarin S, Castagnoli C, Pescarmona G, Silvagno F.

Exp Dermatol. 2015 Oct;24(10):748-53. doi: 10.1111/exd.12761. Epub 2015 Jul 14.


The vitamin D receptor inhibits the respiratory chain, contributing to the metabolic switch that is essential for cancer cell proliferation.

Consiglio M, Destefanis M, Morena D, Foglizzo V, Forneris M, Pescarmona G, Silvagno F.

PLoS One. 2014 Dec 29;9(12):e115816. doi: 10.1371/journal.pone.0115816. eCollection 2014.


Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells.

Riganti C, Castella B, Kopecka J, Campia I, Coscia M, Pescarmona G, Bosia A, Ghigo D, Massaia M.

PLoS One. 2013 Apr 12;8(4):e60975. doi: 10.1371/journal.pone.0060975. Print 2013.


Human protein cluster analysis using amino acid frequencies.

Vernone A, Berchialla P, Pescarmona G.

PLoS One. 2013 Apr 4;8(4):e60220. doi: 10.1371/journal.pone.0060220. Print 2013.


Mitochondrial translocation of vitamin D receptor is mediated by the permeability transition pore in human keratinocyte cell line.

Silvagno F, Consiglio M, Foglizzo V, Destefanis M, Pescarmona G.

PLoS One. 2013;8(1):e54716. doi: 10.1371/journal.pone.0054716. Epub 2013 Jan 22.


Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.

Campia I, Sala V, Kopecka J, Leo C, Mitro N, Costamagna C, Caruso D, Pescarmona G, Crepaldi T, Ghigo D, Bosia A, Riganti C.

Biochem J. 2012 Oct 15;447(2):301-11.


Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity.

Polimeni M, Voena C, Kopecka J, Riganti C, Pescarmona G, Bosia A, Ghigo D.

Biochem J. 2011 Oct 1;439(1):141-9. doi: 10.1042/BJ20102016.


A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells.

Kopecka J, Campia I, Olivero P, Pescarmona G, Ghigo D, Bosia A, Riganti C.

J Control Release. 2011 Jan 20;149(2):196-205. doi: 10.1016/j.jconrel.2010.10.003. Epub 2010 Oct 12.


Analysis of vitamin D receptor expression and clinical correlations in patients with ovarian cancer.

Silvagno F, Poma CB, Realmuto C, Ravarino N, Ramella A, Santoro N, D'Amelio P, Fuso L, Pescarmona G, Zola P.

Gynecol Oncol. 2010 Oct;119(1):121-4. doi: 10.1016/j.ygyno.2010.06.008.


Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies.

Denysenko T, Gennero L, Roos MA, Melcarne A, Juenemann C, Faccani G, Morra I, Cavallo G, Reguzzi S, Pescarmona G, Ponzetto A.

Cell Biochem Funct. 2010 Jul;28(5):343-51. doi: 10.1002/cbf.1666. Review.


Mitochondrial localization of vitamin D receptor in human platelets and differentiated megakaryocytes.

Silvagno F, De Vivo E, Attanasio A, Gallo V, Mazzucco G, Pescarmona G.

PLoS One. 2010 Jan 13;5(1):e8670. doi: 10.1371/journal.pone.0008670.


Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis.

Campia I, Lussiana C, Pescarmona G, Ghigo D, Bosia A, Riganti C.

Br J Pharmacol. 2009 Dec;158(7):1777-86. doi: 10.1111/j.1476-5381.2009.00465.x.


Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.

Riganti C, Campia I, Polimeni M, Pescarmona G, Ghigo D, Bosia A.

Toxicol Appl Pharmacol. 2009 Nov 1;240(3):385-92. doi: 10.1016/j.taap.2009.07.026. Epub 2009 Jul 30.


Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.

Riganti C, Doublier S, Viarisio D, Miraglia E, Pescarmona G, Ghigo D, Bosia A.

Br J Pharmacol. 2009 Apr;156(7):1054-66. doi: 10.1111/j.1476-5381.2009.00117.x. Epub 2009 Mar 9.


Digoxin and ouabain increase the synthesis of cholesterol in human liver cells.

Campia I, Gazzano E, Pescarmona G, Ghigo D, Bosia A, Riganti C.

Cell Mol Life Sci. 2009 May;66(9):1580-94. doi: 10.1007/s00018-009-9018-5.


RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells.

Doublier S, Riganti C, Voena C, Costamagna C, Aldieri E, Pescarmona G, Ghigo D, Bosia A.

Mol Cancer Res. 2008 Oct;6(10):1607-20. doi: 10.1158/1541-7786.MCR-08-0251.


Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells.

Riganti C, Doublier S, Costamagna C, Aldieri E, Pescarmona G, Ghigo D, Bosia A.

Mol Pharmacol. 2008 Aug;74(2):476-84. doi: 10.1124/mol.108.045286. Epub 2008 May 7.


Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition.

Riganti C, Orecchia S, Silvagno F, Pescarmona G, Betta PG, Gazzano E, Aldieri E, Ghigo D, Bosia A.

Am J Respir Cell Mol Biol. 2007 Jun;36(6):746-56. Epub 2007 Feb 22.


Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

Riganti C, Orecchia S, Pescarmona G, Betta PG, Ghigo D, Bosia A.

Int J Cancer. 2006 Jul 1;119(1):17-27.

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