Format

Send to

Choose Destination
Pediatr Neurol. 2014 Jul;51(1):100-3. doi: 10.1016/j.pediatrneurol.2014.03.025. Epub 2014 Mar 30.

Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence.

Author information

1
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.
2
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
3
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: patricia.evans@utsouthwestern.edu.

Abstract

INTRODUCTION:

We present a developmentally appropriate adolescent boy who presented with upper and lower extremity glove-and-stocking paresthesias, distal weakness, vertigo, high-pitched voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months.

CLINICAL INVESTIGATIONS:

Extensive investigations revealed serum thiamine levels <2 nmol/L. Brain magnetic resonance imaging revealed symmetric abnormal T2 prolongation of the mammillary bodies. Nerve conduction studies were consistent with axonal, length-dependent polyneuropathy. Together, these findings were diagnostic for peripheral polyneuropathy and Wernicke encephalopathy secondary to thiamine deficiency.

CONCLUSION:

This patient illustrates that eating disorders can be an uncommon cause of rapidly progressive paresthesias, weakness, and neurological decline due to thiamine deficiency.

KEYWORDS:

Wernicke encephalopathy; anorexia nervosa; dry beriberi; paresthesias; peripheral polyneuropathy; thiamine

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center