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Items: 6

1.

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.

Galmarini CM, Martin M, Bouchet BP, Guillen-Navarro MJ, Martínez-Diez M, Martinez-Leal JF, Akhmanova A, Aviles P.

BMC Cancer. 2018 Feb 7;18(1):164. doi: 10.1186/s12885-018-4086-2.

2.

A previously undescribed tubulin binder.

Field JJ, Waight AB, Senter PD.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13684-5. doi: 10.1073/pnas.1414572111. Epub 2014 Sep 3. No abstract available.

3.

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.

Prota AE, Bargsten K, Diaz JF, Marsh M, Cuevas C, Liniger M, Neuhaus C, Andreu JM, Altmann KH, Steinmetz MO.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. doi: 10.1073/pnas.1408124111. Epub 2014 Aug 11.

4.

PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.

Martínez-Díez M, Guillén-Navarro MJ, Pera B, Bouchet BP, Martínez-Leal JF, Barasoain I, Cuevas C, Andreu JM, García-Fernández LF, Díaz JF, Avilés P, Galmarini CM.

Biochem Pharmacol. 2014 Apr 1;88(3):291-302. doi: 10.1016/j.bcp.2014.01.026. Epub 2014 Jan 31.

PMID:
24486569
5.

New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

Pera B, Barasoain I, Pantazopoulou A, Canales A, Matesanz R, Rodriguez-Salarichs J, García-Fernandez LF, Moneo V, Jiménez-Barbero J, Galmarini CM, Cuevas C, Peñalva MA, Díaz JF, Andreu JM.

ACS Chem Biol. 2013 Sep 20;8(9):2084-94. doi: 10.1021/cb400461j. Epub 2013 Aug 1.

PMID:
23859655
6.

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds.

Martín MJ, Coello L, Fernández R, Reyes F, Rodríguez A, Murcia C, Garranzo M, Mateo C, Sánchez-Sancho F, Bueno S, de Eguilior C, Francesch A, Munt S, Cuevas C.

J Am Chem Soc. 2013 Jul 10;135(27):10164-71. doi: 10.1021/ja404578u. Epub 2013 Jun 26.

PMID:
23750450

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