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Items: 1 to 20 of 180


The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics.

Yamamoto K, Takahashi K, Caputi L, Mizuno H, Rodriguez-Lopez CE, Iwasaki T, Ishizaki K, Fukaki H, Ohnishi M, Yamazaki M, Masujima T, O'Connor SE, Mimura T.

New Phytol. 2019 Oct;224(2):848-859. doi: 10.1111/nph.16138. Epub 2019 Sep 20.


Biosynthesis of an Anti-Addiction Agent from the Iboga Plant.

Farrow SC, Kamileen MO, Caputi L, Bussey K, Mundy JEA, McAtee RC, Stephenson CRJ, O'Connor SE.

J Am Chem Soc. 2019 Aug 21;141(33):12979-12983. doi: 10.1021/jacs.9b05999. Epub 2019 Aug 6.


Biocatalytic Strategies towards [4+2] Cycloadditions.

Lichman BR, O'Connor SE, Kries H.

Chemistry. 2019 May 17;25(28):6864-6877. doi: 10.1002/chem.201805412. Epub 2019 Mar 12. Review.


Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.

Lichman BR, Kamileen MO, Titchiner GR, Saalbach G, Stevenson CEM, Lawson DM, O'Connor SE.

Nat Chem Biol. 2019 Jan;15(1):71-79. doi: 10.1038/s41589-018-0185-2. Epub 2018 Dec 10.


Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis.

Franke J, Kim J, Hamilton JP, Zhao D, Pham GM, Wiegert-Rininger K, Crisovan E, Newton L, Vaillancourt B, Tatsis E, Buell CR, O'Connor SE.

Chembiochem. 2019 Jan 2;20(1):83-87. doi: 10.1002/cbic.201800592. Epub 2018 Nov 13.


Corrigendum to biocatalysts from alkaloid producing plants [Biocatalysts from alkaloid producing plants 31 (2016) 22-30].

Kries H, O'Connor SE.

Curr Opin Chem Biol. 2018 Jun;44:110. doi: 10.1016/j.cbpa.2018.07.007. No abstract available.


Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga.

Farrow SC, Kamileen MO, Meades J, Ameyaw B, Xiao Y, O'Connor SE.

J Biol Chem. 2018 Sep 7;293(36):13821-13833. doi: 10.1074/jbc.RA118.004060. Epub 2018 Jul 20.


Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes.

Dang TT, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O'Connor SE.

Nat Chem Biol. 2018 Aug;14(8):760-763. doi: 10.1038/s41589-018-0078-4. Epub 2018 Jun 25.


Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus.

Carqueijeiro I, Brown S, Chung K, Dang TT, Walia M, Besseau S, Dugé de Bernonville T, Oudin A, Lanoue A, Billet K, Munsch T, Koudounas K, Melin C, Godon C, Razafimandimby B, de Craene JO, Glévarec G, Marc J, Giglioli-Guivarc'h N, Clastre M, St-Pierre B, Papon N, Andrade RB, O'Connor SE, Courdavault V.

Plant Physiol. 2018 Aug;177(4):1473-1486. doi: 10.1104/pp.18.00549. Epub 2018 Jun 22.


Vacuole-Targeted Proteins: Ins and Outs of Subcellular Localization Studies.

Carqueijeiro I, Sepúlveda LJ, Mosquera A, Payne R, Corbin C, Papon N, de Bernonville TD, Besseau S, Lanoue A, Glévarec G, Clastre M, St-Pierre B, Atehortùa L, Giglioli-Guivarc'h N, O'Connor SE, Oudin A, Courdavault V.

Methods Mol Biol. 2018;1789:33-54. doi: 10.1007/978-1-4939-7856-4_4.


Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.

Caputi L, Franke J, Farrow SC, Chung K, Payne RME, Nguyen TD, Dang TT, Soares Teto Carqueijeiro I, Koudounas K, Dugé de Bernonville T, Ameyaw B, Jones DM, Vieira IJC, Courdavault V, O'Connor SE.

Science. 2018 Jun 15;360(6394):1235-1239. doi: 10.1126/science.aat4100. Epub 2018 May 3.


A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.

Carqueijeiro I, Dugé de Bernonville T, Lanoue A, Dang TT, Teijaro CN, Paetz C, Billet K, Mosquera A, Oudin A, Besseau S, Papon N, Glévarec G, Atehortùa L, Clastre M, Giglioli-Guivarc'h N, Schneider B, St-Pierre B, Andrade RB, O'Connor SE, Courdavault V.

Plant J. 2018 May;94(3):469-484. doi: 10.1111/tpj.13868. Epub 2018 Mar 27.


Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid.

Stavrinides AK, Tatsis EC, Dang TT, Caputi L, Stevenson CEM, Lawson DM, Schneider B, O'Connor SE.

Chembiochem. 2018 May 4;19(9):940-948. doi: 10.1002/cbic.201700621. Epub 2018 Mar 22.


Raising the BAR of specificity.

O'Connor SE.

Nat Plants. 2017 Dec;3(12):924-925. doi: 10.1038/s41477-017-0074-9. No abstract available.


Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry.

Sherden NH, Lichman B, Caputi L, Zhao D, Kamileen MO, Buell CR, O'Connor SE.

Phytochemistry. 2018 Jan;145:48-56. doi: 10.1016/j.phytochem.2017.10.004. Epub 2017 Nov 5.


Identification of Iridoid Glucoside Transporters in Catharanthus roseus.

Larsen B, Fuller VL, Pollier J, Van Moerkercke A, Schweizer F, Payne R, Colinas M, O'Connor SE, Goossens A, Halkier BA.

Plant Cell Physiol. 2017 Sep 1;58(9):1507-1518. doi: 10.1093/pcp/pcx097.


A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.

Tatsis EC, Carqueijeiro I, Dugé de Bernonville T, Franke J, Dang TT, Oudin A, Lanoue A, Lafontaine F, Stavrinides AK, Clastre M, Courdavault V, O'Connor SE.

Nat Commun. 2017 Aug 22;8(1):316. doi: 10.1038/s41467-017-00154-x.


Inverted stereocontrol of iridoid synthase in snapdragon.

Kries H, Kellner F, Kamileen MO, O'Connor SE.

J Biol Chem. 2017 Sep 1;292(35):14659-14667. doi: 10.1074/jbc.M117.800979. Epub 2017 Jul 12.


Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina.

Dang TT, Franke J, Tatsis E, O'Connor SE.

Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9440-9444. doi: 10.1002/anie.201705010. Epub 2017 Jul 12.


Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species.

Leisner CP, Kamileen MO, Conway ME, O'Connor SE, Buell CR.

PLoS One. 2017 Jun 13;12(6):e0179417. doi: 10.1371/journal.pone.0179417. eCollection 2017.

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