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Items: 1 to 20 of 67

1.

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.

Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T.

Hum Mol Genet. 2016 Jul 15;25(14):2948-2958.

PMID:
27179792
2.

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase.

Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T.

Nat Commun. 2014 Feb 28;5:3386. doi: 10.1038/ncomms4386.

PMID:
24577224
3.

[Alzheimer disease: experimental approaches to genetic and environmental risk factors].

Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y.

Rinsho Shinkeigaku. 2013;53(11):956. Japanese. No abstract available.

PMID:
24291845
4.

Protein trafficking and maturation regulate intramembrane proteolysis.

Morohashi Y, Tomita T.

Biochim Biophys Acta. 2013 Dec;1828(12):2855-61. doi: 10.1016/j.bbamem.2013.06.001. Review.

5.

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T.

Oncogene. 2012 Feb 9;31(6):787-98. doi: 10.1038/onc.2011.265.

6.

[Molecular targeted therapy in Alzheimer disease].

Morohashi Y, Tomita T, Iwatsubo T.

Nihon Rinsho. 2010 Oct;68(10):1906-10. Review. Japanese.

PMID:
20954338
7.

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Grønborg M, Möbius W, Rhee J, Barr FA, Simons M.

J Cell Biol. 2010 Apr 19;189(2):223-32. doi: 10.1083/jcb.200911018.

8.

Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis.

Morohashi Y, Balklava Z, Ball M, Hughes H, Lowe M.

Biochem J. 2010 Apr 14;427(3):401-12. doi: 10.1042/BJ20091681.

PMID:
20175751
9.

Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction.

Mitsuoka K, Tamai I, Morohashi Y, Kubo Y, Saitoh R, Tsuji A, Kato Y.

Biol Pharm Bull. 2009 Aug;32(8):1459-61.

10.

Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner.

Diao A, Frost L, Morohashi Y, Lowe M.

J Biol Chem. 2008 Mar 14;283(11):6957-67. doi: 10.1074/jbc.M708401200.

11.

Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking.

Szul T, Grabski R, Lyons S, Morohashi Y, Shestopal S, Lowe M, Sztul E.

J Cell Sci. 2007 Nov 15;120(Pt 22):3929-40.

12.

Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.

Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T.

Org Lett. 2007 May 24;9(11):2055-8.

PMID:
17480083
13.

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.

Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T.

J Biol Chem. 2007 Apr 27;282(17):12388-96.

14.

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

Sato C, Morohashi Y, Tomita T, Iwatsubo T.

J Neurosci. 2006 Nov 15;26(46):12081-8.

15.

Presenilin-dependent intramembrane cleavage of ephrin-B1.

Tomita T, Tanaka S, Morohashi Y, Iwatsubo T.

Mol Neurodegener. 2006 Jun 12;1:2.

16.

C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).

Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T.

J Biol Chem. 2006 May 26;281(21):14670-6.

17.

Development of polyphenol oxidase activity in the micropylar endosperm of tomato seeds.

Maki H, Morohashi Y.

J Plant Physiol. 2006 Jan;163(1):1-10.

PMID:
16360798
18.

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.

Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T.

J Biol Chem. 2005 Dec 23;280(51):41967-75.

19.

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T.

J Biol Chem. 2005 Apr 1;280(13):12967-75.

20.

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.

Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1983-5.

PMID:
15050642
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