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Novel SFRP2 DNA Methylation Profile Following Neoadjuvant Therapy in Colorectal Cancer Patients with Different Grades of BMI.

Cabrera-Mulero A, Crujeiras AB, Izquierdo AG, Torres E, Ayers D, Casanueva FF, Tinahones FJ, Morcillo S, Macias-Gonzalez M.

J Clin Med. 2019 Jul 17;8(7). pii: E1041. doi: 10.3390/jcm8071041.


Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients.

Castellano-Castillo D, Morcillo S, Crujeiras AB, Sánchez-Alcoholado L, Clemente-Postigo M, Torres E, Tinahones FJ, Macias-Gonzalez M.

BMC Cancer. 2019 Jan 21;19(1):93. doi: 10.1186/s12885-018-5226-4.


Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables.

Castellano-Castillo D, Moreno-Indias I, Sanchez-Alcoholado L, Ramos-Molina B, Alcaide-Torres J, Morcillo S, Ocaña-Wilhelmi L, Tinahones F, Queipo-Ortuño MI, Cardona F.

J Clin Med. 2019 Jan 13;8(1). pii: E87. doi: 10.3390/jcm8010087.


Decreased blood pressure is related to changes in NF-kB promoter methylation levels after bariatric surgery.

Macías-González M, Martín-Núñez GM, Garrido-Sánchez L, García-Fuentes E, Tinahones FJ, Morcillo S.

Surg Obes Relat Dis. 2018 Sep;14(9):1327-1334. doi: 10.1016/j.soard.2018.06.011. Epub 2018 Jun 23.


Adipose tissue inflammation and VDR expression and methylation in colorectal cancer.

Castellano-Castillo D, Morcillo S, Clemente-Postigo M, Crujeiras AB, Fernandez-García JC, Torres E, Tinahones FJ, Macias-Gonzalez M.

Clin Epigenetics. 2018 Apr 25;10:60. doi: 10.1186/s13148-018-0493-0. eCollection 2018.


Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis.

Crujeiras AB, Morcillo S, Diaz-Lagares A, Sandoval J, Castellano-Castillo D, Torres E, Hervas D, Moran S, Esteller M, Macias-Gonzalez M, Casanueva FF, Tinahones FJ.

Int J Obes (Lond). 2019 Jan;43(1):176-188. doi: 10.1038/s41366-018-0065-6. Epub 2018 May 1.


The Effect of Metabolic and Bariatric Surgery on DNA Methylation Patterns.

Morcillo S, Macías-González M, Tinahones FJ.

Curr Atheroscler Rep. 2017 Aug 30;19(10):40. doi: 10.1007/s11883-017-0676-8. Review.


Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids.

Morcillo S, Martín-Núñez GM, García-Serrano S, Gutierrez-Repiso C, Rodriguez-Pacheco F, Valdes S, Gonzalo M, Rojo-Martinez G, Moreno-Ruiz FJ, Rodriguez-Cañete A, Tinahones F, García-Fuentes E.

Sci Rep. 2017 Apr 10;7:46292. doi: 10.1038/srep46292.


No effect of different bariatric surgery procedures on LINE-1 DNA methylation in diabetic and nondiabetic morbidly obese patients.

Martín-Núñez GM, Cabrera-Mulero A, Alcaide-Torres J, García-Fuentes E, Tinahones FJ, Morcillo S.

Surg Obes Relat Dis. 2017 Mar;13(3):442-450. doi: 10.1016/j.soard.2016.10.014. Epub 2016 Oct 21.


The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences.

Bandera Merchan B, Morcillo S, Martin-Nuñez G, Tinahones FJ, Macías-González M.

J Steroid Biochem Mol Biol. 2017 Mar;167:203-218. doi: 10.1016/j.jsbmb.2016.11.020. Epub 2016 Nov 30. Review.


Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.

Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP, Montasser ME, Landenvall C, Staiger H, Luan J, Frayling TM, Weedon MN, Xie W, Morcillo S, Martínez-Larrad MT, Biggs ML, Chen YD, Corbaton-Anchuelo A, Færch K, Gómez-Zumaquero JM, Goodarzi MO, Kizer JR, Koistinen HA, Leong A, Lind L, Lindgren C, Machicao F, Manning AK, Martín-Núñez GM, Rojo-Martínez G, Rotter JI, Siscovick DS, Zmuda JM, Zhang Z, Serrano-Rios M, Smith U, Soriguer F, Hansen T, Jørgensen TJ, Linnenberg A, Pedersen O, Walker M, Langenberg C, Scott RA, Wareham NJ, Fritsche A, Häring HU, Stefan N, Groop L, O'Connell JR, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, März W, Kovacs P, Stumvoll M, Psaty BM, Kuusisto J, Laakso M, Meigs JB, Dupuis J, Ingelsson E, Florez JC.

Diabetes. 2016 Oct;65(10):3200-11. doi: 10.2337/db16-0199. Epub 2016 Jul 14.


Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids.

Monastero R, García-Serrano S, Lago-Sampedro A, Rodríguez-Pacheco F, Colomo N, Morcillo S, Martín-Nuñez GM, Gomez-Zumaquero JM, García-Fuentes E, Soriguer F, Rojo-Martínez G, García-Escobar E.

Eur J Nutr. 2017 Mar;56(2):715-726. doi: 10.1007/s00394-015-1115-7. Epub 2015 Dec 26.


The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study.

Mansego ML, De Marco G, Ivorra C, Lopez-Izquierdo R, Morcillo S, Rojo-Martínez G, González-Albert V, Martinez F, Soriguer F, Martín-Escudero JC, Redon J, Chaves FJ.

J Transl Med. 2015 Sep 2;13:286. doi: 10.1186/s12967-015-0652-4.


Polymorphisms in endothelin system genes, arsenic levels and obesity risk.

Martínez-Barquero V, de Marco G, Martínez-Hervas S, Rentero P, Galan-Chilet I, Blesa S, Morchon D, Morcillo S, Rojo G, Ascaso JF, Real JT, Martín-Escudero JC, Chaves FJ.

PLoS One. 2015 Mar 23;10(3):e0118471. doi: 10.1371/journal.pone.0118471. eCollection 2015.


Changes in thyroid function with age: results from the Pizarra population-based longitudinal study.

Lago-Sampedro AM, Gutiérrez-Repiso C, Valdés S, Maldonado C, Colomo N, Almaraz MC, Rubio-Martín E, Morcillo S, Esteva I, Ruiz de Adana MS, Perez-Valero V, Soriguer F, Rojo-Martínez G, García-Fuentes E.

Int J Clin Pract. 2015 May;69(5):577-87. doi: 10.1111/ijcp.12545. Epub 2015 Jan 21.


Type 2 diabetes mellitus in relation to global LINE-1 DNA methylation in peripheral blood: a cohort study.

Martín-Núñez GM, Rubio-Martín E, Cabrera-Mulero R, Rojo-Martínez G, Olveira G, Valdés S, Soriguer F, Castaño L, Morcillo S.

Epigenetics. 2014 Oct;9(10):1322-8. doi: 10.4161/15592294.2014.969617.


Night-time sleep duration and the incidence of obesity and type 2 diabetes. Findings from the prospective Pizarra study.

Gutiérrez-Repiso C, Soriguer F, Rubio-Martín E, Esteva de Antonio I, Ruiz de Adana MS, Almaraz MC, Olveira-Fuster G, Morcillo S, Valdés S, Lago-Sampedro AM, García-Fuentes E, Rojo-Martínez G.

Sleep Med. 2014 Nov;15(11):1398-404. doi: 10.1016/j.sleep.2014.06.014. Epub 2014 Aug 11.


Methylation levels of the SCD1 gene promoter and LINE-1 repeat region are associated with weight change: an intervention study.

Martín-Núñez GM, Cabrera-Mulero R, Rubio-Martín E, Rojo-Martínez G, Olveira G, Valdés S, Soriguer F, Castaño L, Morcillo S.

Mol Nutr Food Res. 2014 Jul;58(7):1528-36. doi: 10.1002/mnfr.201400079. Epub 2014 May 15.


Modifications of the homeostasis model assessment of insulin resistance index with age.

Soriguer F, Colomo N, Valdés S, Goday A, Rubio-Martín E, Esteva I, Castaño L, Ruiz de Adana MS, Morcillo S, Calle A, García-Fuentes E, Catalá M, Gutiérrez-Repiso C, Delgado E, Gomis R, Ortega E, Rojo-Martínez G.

Acta Diabetol. 2014 Dec;51(6):917-25. doi: 10.1007/s00592-013-0523-5. Epub 2014 Apr 1.


Impact of obesity-related genes in Spanish population.

Martínez-García F, Mansego ML, Rojo-Martínez G, De Marco-Solar G, Morcillo S, Soriguer F, Redón J, Pineda Alonso M, Martín-Escudero JC, Cooper RS, Chaves FJ.

BMC Genet. 2013 Nov 23;14:111. doi: 10.1186/1471-2156-14-111.

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