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Items: 16


Relationship between air mass type and emergency department visits for migraine headache across the Triangle region of North Carolina.

Elcik C, Fuhrmann CM, Mercer AE, Davis RE.

Int J Biometeorol. 2017 Dec;61(12):2245-2254. doi: 10.1007/s00484-017-1432-z. Epub 2017 Sep 13.


A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA.

Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159.


Question 2: can a conservative approach to the treatment of hypertrophic pyloric stenosis with atropine be considered a real alternative to surgical pyloromyotomy?

Mercer AE, Phillips R.

Arch Dis Child. 2013 Jun;98(6):474-7. doi: 10.1136/archdischild-2013-303655. Review. No abstract available.


Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

Copple IM, Mercer AE, Firman J, Donegan G, Herpers B, Wong MH, Chadwick J, Bringela AD, Cristiano ML, van de Water B, Ward SA, O'Neill PM, Park BK.

Mol Med. 2012 Sep 25;18:1045-55. doi: 10.2119/molmed.2012.00154.


The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations.

Mercer AE, Sarr Sallah M.

Expert Opin Drug Metab Toxicol. 2011 Apr;7(4):427-39. doi: 10.1517/17425255.2011.557064. Epub 2011 Feb 15. Review.


The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

Mercer AE, Copple IM, Maggs JL, O'Neill PM, Park BK.

J Biol Chem. 2011 Jan 14;286(2):987-96. doi: 10.1074/jbc.M110.144188. Epub 2010 Nov 8.


Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

Amewu R, Gibbons P, Mukhtar A, Stachulski AV, Ward SA, Hall C, Rimmer K, Davies J, Vivas L, Bacsa J, Mercer AE, Nixon G, Stocks PA, O'Neill PM.

Org Biomol Chem. 2010 May 7;8(9):2068-77. doi: 10.1039/b924319d. Epub 2010 Mar 3.


Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

Chadwick J, Jones M, Mercer AE, Stocks PA, Ward SA, Park BK, O'Neill PM.

Bioorg Med Chem. 2010 Apr 1;18(7):2586-97. doi: 10.1016/j.bmc.2010.02.035. Epub 2010 Feb 23.


Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.

Antoine DJ, Mercer AE, Williams DP, Park BK.

Xenobiotica. 2009 Aug;39(8):565-77. doi: 10.1080/00498250903046993. Review.


Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK.

Toxicol Appl Pharmacol. 2009 Sep 15;239(3):297-305. doi: 10.1016/j.taap.2009.05.027. Epub 2009 Jun 10.


Antitumour and antimalarial activity of artemisinin-acridine hybrids.

Jones M, Mercer AE, Stocks PA, La Pensée LJ, Cosstick R, Park BK, Kennedy ME, Piantanida I, Ward SA, Davies J, Bray PG, Rawe SL, Baird J, Charidza T, Janneh O, O'Neill PM.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):2033-7. doi: 10.1016/j.bmcl.2009.02.028. Epub 2009 Feb 11.


The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials.

Mercer AE.

Curr Opin Drug Discov Devel. 2009 Jan;12(1):125-32. Review.


Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.

Chadwick J, Mercer AE, Park BK, Cosstick R, O'Neill PM.

Bioorg Med Chem. 2009 Feb 1;17(3):1325-38. doi: 10.1016/j.bmc.2008.12.017. Epub 2008 Dec 24.


Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Stocks PA, Bray PG, Barton VE, Al-Helal M, Jones M, Araujo NC, Gibbons P, Ward SA, Hughes RH, Biagini GA, Davies J, Amewu R, Mercer AE, Ellis G, O'Neill PM.

Angew Chem Int Ed Engl. 2007;46(33):6278-83. No abstract available.


Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds.

Mercer AE, Maggs JL, Sun XM, Cohen GM, Chadwick J, O'Neill PM, Park BK.

J Biol Chem. 2007 Mar 30;282(13):9372-82. Epub 2007 Jan 16.


Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM.

J Med Chem. 2004 Feb 26;47(5):1290-8.


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