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Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E, Schiffers S, Karnik R, Meissner A, Carell T, Rathert P, Jurkowska RZ, Jeltsch A.

Nucleic Acids Res. 2018 Aug 8. doi: 10.1093/nar/gky715. [Epub ahead of print]


Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress.

Sacerdoti D, Singh SP, Schragenheim J, Bellner L, Vanella L, Raffaele M, Meissner A, Grant I, Favero G, Rezzani R, Rodella LF, Bamshad D, Lebovics E, Abraham NG.

Int J Hepatol. 2018 Jul 2;2018:3484107. doi: 10.1155/2018/3484107. eCollection 2018.


Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.

Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K.

Cell Stem Cell. 2018 Aug 2;23(2):289-305.e5. doi: 10.1016/j.stem.2018.06.013. Epub 2018 Jul 12.


The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension.

Don-Doncow N, Zhang Y, Matuskova H, Meissner A.

Br J Pharmacol. 2018 Jun 1. doi: 10.1111/bph.14381. [Epub ahead of print] Review.


An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.

Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI.

Cell Stem Cell. 2018 Jun 1;22(6):851-864.e5. doi: 10.1016/j.stem.2018.04.021. Epub 2018 May 24.


Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.

Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, Madison J, Muller M, Arlotta P, Fu Z, Feng G, Eggan K.

Cell Rep. 2018 May 22;23(8):2509-2523. doi: 10.1016/j.celrep.2018.04.066.


EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter.

Schragenheim J, Bellner L, Cao J, Singh SP, Bamshad D, McClung JA, Maayan O, Meissner A, Grant I, Stier CT Jr, Abraham NG.

Prostaglandins Other Lipid Mediat. 2018 Jul;137:30-39. doi: 10.1016/j.prostaglandins.2018.05.008. Epub 2018 May 19.


Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism.

Glaenzel U, Jin Y, Nufer R, Li W, Schroer K, Adam-Stitah S, Peter van Marle S, Legangneux E, Borell H, James AD, Meissner A, Camenisch G, Gardin A.

Drug Metab Dispos. 2018 Jul;46(7):1001-1013. doi: 10.1124/dmd.117.079574. Epub 2018 May 7.


[Heart Failure Despite Low BNP-Level: Paradoxon or Pathfinder? - - A Case of Pericarditis constrictiva].

Dopp H, Maagh P, Meissner A.

Dtsch Med Wochenschr. 2018 May;143(10):731-734. doi: 10.1055/a-0600-1645. Epub 2018 May 4. German.


The risk of TESE-induced hypogonadism: a systematic review and meta-analysis.

Eliveld J, van Wely M, Meißner A, Repping S, van der Veen F, van Pelt AMM.

Hum Reprod Update. 2018 Jul 1;24(4):442-454. doi: 10.1093/humupd/dmy015.


X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs.

Pasque V, Karnik R, Chronis C, Petrella P, Langerman J, Bonora G, Song J, Vanheer L, Sadhu Dimashkie A, Meissner A, Plath K.

Stem Cell Reports. 2018 May 8;10(5):1537-1550. doi: 10.1016/j.stemcr.2018.03.019. Epub 2018 Apr 19.


Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, Van Allen EM, Miao D, Huang Y, Snyder A, Merghoub T, Wolchok JD, Garraway LA, Meissner A, Weber JS, Hacohen N, Neuberg D, Potts PR, Murphy GF, Lian CG, Schadendorf D, Hodi FS, Wu CJ.

Cell. 2018 Apr 19;173(3):624-633.e8. doi: 10.1016/j.cell.2018.03.026. Epub 2018 Apr 12.


A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.

Cesana M, Guo MH, Cacchiarelli D, Wahlster L, Barragan J, Doulatov S, Vo LT, Salvatori B, Trapnell C, Clement K, Cahan P, Tsanov KM, Sousa PM, Tazon-Vega B, Bolondi A, Giorgi FM, Califano A, Rinn JL, Meissner A, Hirschhorn JN, Daley GQ.

Cell Stem Cell. 2018 Apr 5;22(4):575-588.e7. doi: 10.1016/j.stem.2018.03.012.


Author Correction: Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):355. doi: 10.1038/s41594-018-0055-3.


Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.

Ziller MJ, Ortega JA, Quinlan KA, Santos DP, Gu H, Martin EJ, Galonska C, Pop R, Maidl S, Di Pardo A, Huang M, Meltzer HY, Gnirke A, Heckman CJ, Meissner A, Kiskinis E.

Cell Stem Cell. 2018 Apr 5;22(4):559-574.e9. doi: 10.1016/j.stem.2018.02.012. Epub 2018 Mar 15.


Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):327-332. doi: 10.1038/s41594-018-0046-4. Epub 2018 Mar 12. Erratum in: Nat Struct Mol Biol. 2018 Mar 26;:.


Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain.

Janssens S, Schotsaert M, Karnik R, Balasubramaniam V, Dejosez M, Meissner A, García-Sastre A, Zwaka TP.

mSystems. 2018 Feb 6;3(1). pii: e00219-17. doi: 10.1128/mSystems.00219-17. eCollection 2018 Jan-Feb.


Genome-wide tracking of dCas9-methyltransferase footprints.

Galonska C, Charlton J, Mattei AL, Donaghey J, Clement K, Gu H, Mohammad AW, Stamenova EK, Cacchiarelli D, Klages S, Timmermann B, Cantz T, Schöler HR, Gnirke A, Ziller MJ, Meissner A.

Nat Commun. 2018 Feb 9;9(1):597. doi: 10.1038/s41467-017-02708-5.


Genetic determinants and epigenetic effects of pioneer-factor occupancy.

Donaghey J, Thakurela S, Charlton J, Chen JS, Smith ZD, Gu H, Pop R, Clement K, Stamenova EK, Karnik R, Kelley DR, Gifford CA, Cacchiarelli D, Rinn JL, Gnirke A, Ziller MJ, Meissner A.

Nat Genet. 2018 Feb;50(2):250-258. doi: 10.1038/s41588-017-0034-3. Epub 2018 Jan 22.


Point-by-point versus multisite electrode mapping in VT ablation: does freedom from VT recurrences depend on mapping catheter? An observational study.

Maagh P, Christoph A, Müller MS, Dopp H, Plehn G, Meissner A.

J Interv Card Electrophysiol. 2018 Mar;51(2):169-181. doi: 10.1007/s10840-018-0311-9. Epub 2018 Jan 22.


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