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A novel mode of capping protein-regulation by twinfilin.

Johnston AB, Hilton DM, McConnell P, Johnson B, Harris MT, Simone A, Amarasinghe GK, Cooper JA, Goode BL.

Elife. 2018 Oct 23;7. pii: e41313. doi: 10.7554/eLife.41313.


A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.

Birch JL, Strathdee K, Gilmour L, Vallatos A, McDonald L, Kouzeli A, Vasan R, Qaisi AH, Croft DR, Crighton D, Gill K, Gray CH, Konczal J, Mezna M, McArthur D, Schüttelkopf AW, McConnell P, Sime M, Holmes WM, Bower J, McKinnon HJ, Drysdale M, Olson MF, Chalmers AJ.

Cancer Res. 2018 Nov 15;78(22):6509-6522. doi: 10.1158/0008-5472.CAN-18-1697. Epub 2018 Oct 2.


Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.

Johnson B, McConnell P, Kozlov AG, Mekel M, Lohman TM, Gross ML, Amarasinghe GK, Cooper JA.

Cell Rep. 2018 May 29;23(9):2795-2804. doi: 10.1016/j.celrep.2018.04.096.


Effects of Preoperative Curcumin on the Inflammatory Response During Mechanical Circulatory Support: A Porcine Model.

Ma P, Tumin D, Cismowski M, Tobias JD, Gomez D, McConnell P, Naguib A, Yates AR, Winch P.

Cardiol Res. 2018 Feb;9(1):7-10. doi: 10.14740/cr677w. Epub 2018 Feb 11.


Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.

Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schüttelkopf AW, Sime M, Olson MF.

Cancer Res. 2018 Apr 15;78(8):2096-2114. doi: 10.1158/0008-5472.CAN-17-2870. Epub 2018 Jan 30.


Research ethics committee approval as reported for abstracts submitted to the annual Euroanaesthesia meeting.

McConnell P, Kaufman N, De Hert S, Samama CM, Molnar Z, Einav S.

Eur J Anaesthesiol. 2017 Dec;34(12):824-830. doi: 10.1097/EJA.0000000000000669.


Costs of Transforming Established Primary Care Practices to Patient-Centered Medical Homes (PCMHs).

Fleming NS, da Graca B, Ogola GO, Culler SD, Austin J, McConnell P, McCorkle R, Aponte P, Massey M, Fullerton C.

J Am Board Fam Med. 2017 Jul-Aug;30(4):460-471. doi: 10.3122/jabfm.2017.04.170039.


Analysis of Anthrax Immune Globulin Intravenous with Antimicrobial Treatment in Injection Drug Users, Scotland, 2009-2010.

Cui X, Nolen LD, Sun J, Booth M, Donaldson L, Quinn CP, Boyer AE, Hendricks K, Shadomy S, Bothma P, Judd O, McConnell P, Bower WA, Eichacker PQ.

Emerg Infect Dis. 2017 Jan;23(1):56-65. doi: 10.3201/eid2301.160608.


Extracorporeal Membrane Oxygenation Outcomes After the Comprehensive Stage II Procedure in Patients With Single Ventricles.

Gomez D, Duffy V, Hersey D, Backes C, Rycus P, McConnell P, Voss J, Galantowicz M, Cua CL.

Artif Organs. 2017 Jan;41(1):66-70. doi: 10.1111/aor.12810. Epub 2016 Nov 29.


Preliminary Experience in the Use of an Extracellular Matrix (CorMatrix) as a Tube Graft: Word of Caution.

Hibino N, McConnell P, Shinoka T, Malik M, Galantowicz M.

Semin Thorac Cardiovasc Surg. 2015 Autumn;27(3):288-95. doi: 10.1053/j.semtcvs.2015.08.008. Epub 2015 Sep 1.


Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2.

Lanier MH, McConnell P, Cooper JA.

J Biol Chem. 2016 Jan 15;291(3):1076-91. doi: 10.1074/jbc.M115.676882. Epub 2015 Nov 17.


CPI motif interaction is necessary for capping protein function in cells.

Edwards M, McConnell P, Schafer DA, Cooper JA.

Nat Commun. 2015 Sep 28;6:8415. doi: 10.1038/ncomms9415.


A single-center strategy to minimize blood transfusion in neonates and children undergoing cardiac surgery.

Naguib AN, Winch PD, Tobias JD, Simsic J, Hersey D, Nicol K, Preston T, Gomez D, McConnell P, Galantowicz M.

Paediatr Anaesth. 2015 May;25(5):477-86. doi: 10.1111/pan.12604. Epub 2015 Jan 12.


A novel small-molecule MRCK inhibitor blocks cancer cell invasion.

Unbekandt M, Croft DR, Crighton D, Mezna M, McArthur D, McConnell P, Schüttelkopf AW, Belshaw S, Pannifer A, Sime M, Bower J, Drysdale M, Olson MF.

Cell Commun Signal. 2014 Oct 5;12:54. doi: 10.1186/s12964-014-0054-x.


Confirmed Bacillus anthracis infection among persons who inject drugs, Scotland, 2009-2010.

Booth M, Donaldson L, Cui X, Sun J, Cole S, Dailsey S, Hart A, Johns N, McConnell P, McLennan T, Parcell B, Robb H, Shippey B, Sim M, Wallis C, Eichacker PQ.

Emerg Infect Dis. 2014 Sep;20(9):1452-63. doi: 10.3201/eid2009.131481.


Accuracy of noninvasive and continuous hemoglobin measurement by pulse co-oximetry during preoperative phlebotomy.

Dewhirst E, Naguib A, Winch P, Rice J, Galantowicz M, McConnell P, Tobias JD.

J Intensive Care Med. 2014 Jul-Aug;29(4):238-42. doi: 10.1177/0885066613485355. Epub 2013 Apr 22.


Subclavian vein aneurysm secondary to a benign vessel wall hamartoma.

Warren P, Spaeth M, Prasad V, McConnell P.

Pediatr Radiol. 2013 Nov;43(11):1528-31. doi: 10.1007/s00247-013-2697-y. Epub 2013 May 2.


Students delivering health care to a vulnerable Appalachian population through interprofessional service-learning.

Lee ML, Hayes PA, McConnell P, Henry RM.

Gerontol Geriatr Educ. 2013;34(1):43-59. doi: 10.1080/02701960.2013.737388.


Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Powell NA, Hoffman JK, Ciske FL, Kaufman MD, Kohrt JT, Quin J 3rd, Sheehan DJ, Delaney A, Baxi SM, Catana C, McConnell P, Ohren J, Perrin LA, Edmunds JJ.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1046-50. doi: 10.1016/j.bmcl.2012.12.013. Epub 2012 Dec 20.


A progressive nurse practitioner student evaluation tool.

Pearson T, Garrett L, Hossler S, McConnell P, Walls J.

J Am Acad Nurse Pract. 2012 Jun;24(6):352-7. doi: 10.1111/j.1745-7599.2012.00713.x. Epub 2012 Apr 30.


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