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O6-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function.

Ezerskyte M, Paredes JA, Malvezzi S, Burns JA, Margison GP, Olsson M, Scicchitano DA, Dreij K.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4731-4736. doi: 10.1073/pnas.1721764115. Epub 2018 Apr 17.


L-β-N-methylamino-l-alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease.

Potjewyd G, Day PJ, Shangula S, Margison GP, Povey AC.

Neurotoxicology. 2017 Mar;59:105-109. doi: 10.1016/j.neuro.2017.01.007. Epub 2017 Feb 3.


IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide.

Ramcharan R, Aleksic T, Kamdoum WP, Gao S, Pfister SX, Tanner J, Bridges E, Asher R, Watson AJ, Margison GP, Woodcock M, Repapi E, Li JL, Middleton MR, Macaulay VM.

Oncotarget. 2015 Nov 24;6(37):39877-90. doi: 10.18632/oncotarget.5631.


MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide.

Erice O, Smith MP, White R, Goicoechea I, Barriuso J, Jones C, Margison GP, Acosta JC, Wellbrock C, Arozarena I.

Mol Cancer Ther. 2015 May;14(5):1236-46. doi: 10.1158/1535-7163.MCT-14-0810. Epub 2015 Mar 16.


The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity.

Tomaszowski KH, Aasland D, Margison GP, Williams E, Pinder SI, Modesti M, Fuchs RP, Kaina B.

DNA Repair (Amst). 2015 Apr;28:14-20. doi: 10.1016/j.dnarep.2015.01.009. Epub 2015 Jan 31.


Increased N7-methyldeoxyguanosine DNA adducts after occupational exposure to pesticides and influence of genetic polymorphisms of paraoxonase-1 and glutathione S-transferase M1 and T1.

Gómez-Martín A, Altakroni B, Lozano-Paniagua D, Margison GP, de Vocht F, Povey AC, Hernández AF.

Environ Mol Mutagen. 2015 Jun;56(5):437-45. doi: 10.1002/em.21929. Epub 2014 Nov 26.


Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells.

Arozarena I, Goicoechea I, Erice O, Ferguson J, Margison GP, Wellbrock C.

Mol Cancer. 2014 Jun 19;13:154. doi: 10.1186/1476-4598-13-154.


O⁶-carboxymethylguanine in DNA forms a sequence context-dependent wobble base-pair structure with thymine.

Zhang F, Tsunoda M, Kikuchi Y, Wilkinson O, Millington CL, Margison GP, Williams DM, Takénaka A.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1669-79. doi: 10.1107/S1399004714006178. Epub 2014 May 30.


Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.

Nyskohus LS, Watson AJ, Margison GP, Le Leu RK, Kim SW, Lockett TJ, Head RJ, Young GP, Hu Y.

Mutat Res. 2013 Dec 12;758(1-2):80-6. doi: 10.1016/j.mrgentox.2013.10.001. Epub 2013 Oct 16.


Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours.

Bonello N, Sampson J, Burn J, Wilson IJ, McGrown G, Margison GP, Thorncroft M, Crossbie P, Povey AC, Santibanez-Koref M, Walters K.

J Theor Biol. 2013 Nov 7;336:87-95. doi: 10.1016/j.jtbi.2013.07.019. Epub 2013 Jul 30.


Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue.

Crosbie PA, Harrison K, Shah R, Watson AJ, Agius R, Barber PV, Margison GP, Povey AC.

Chem Biol Interact. 2013 Jul 5;204(2):98-104. doi: 10.1016/j.cbi.2013.04.013. Epub 2013 May 9.


Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations.

Zhang F, Tsunoda M, Suzuki K, Kikuchi Y, Wilkinson O, Millington CL, Margison GP, Williams DM, Czarina Morishita E, Takénaka A.

Nucleic Acids Res. 2013 May 1;41(10):5524-32. doi: 10.1093/nar/gkt198. Epub 2013 Apr 10.


Triazene compounds in the treatment of acute myeloid leukemia: a short review and a case report.

Bonmassar L, Marchesi F, Pascale E, Franzese O, Margison GP, Bianchi A, D'Atri S, Bernardini S, Lattuada D, Bonmassar E, Aquino A.

Curr Med Chem. 2013;20(19):2389-401. Review.


The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase.

Senthong P, Millington CL, Wilkinson OJ, Marriott AS, Watson AJ, Reamtong O, Eyers CE, Williams DM, Margison GP, Povey AC.

Nucleic Acids Res. 2013 Mar 1;41(5):3047-55. doi: 10.1093/nar/gks1476. Epub 2013 Jan 17.


Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.

Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18755-60. doi: 10.1073/pnas.1209451109. Epub 2012 Oct 29.


Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1.

Abdu K, Aiertza MK, Wilkinson OJ, Grasby JA, Senthong P, Povey AC, Margison GP, Williams DM.

Chem Commun (Camb). 2012 Nov 25;48(91):11214-6. doi: 10.1039/c2cc36252j. Epub 2012 Oct 11.


Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus.

O'Hanlon KA, Margison GP, Hatch A, Fitzpatrick DA, Owens RA, Doyle S, Jones GW.

Nucleic Acids Res. 2012 Sep;40(16):7806-20. doi: 10.1093/nar/gks522. Epub 2012 Jun 4.


Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

Latypov VF, Tubbs JL, Watson AJ, Marriott AS, McGown G, Thorncroft M, Wilkinson OJ, Senthong P, Butt A, Arvai AS, Millington CL, Povey AC, Williams DM, Santibanez-Koref MF, Tainer JA, Margison GP.

Mol Cell. 2012 Jul 13;47(1):50-60. doi: 10.1016/j.molcel.2012.04.028. Epub 2012 May 31.


Convenient and efficient syntheses of oligodeoxyribonucleotides containing O(6)-(carboxymethyl)guanine and O(6)-(4-oxo-4-(3-pyridyl)butyl)guanine.

Millington CL, Watson AJ, Marriott AS, Margison GP, Povey AC, Williams DM.

Nucleosides Nucleotides Nucleic Acids. 2012 Apr;31(4):328-38. doi: 10.1080/15257770.2012.656784.


Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer.

Crosbie PA, Watson AJ, Agius R, Barber PV, Margison GP, Povey AC.

Mutat Res. 2012 Apr 1;732(1-2):43-6. doi: 10.1016/j.mrfmmm.2012.01.001. Epub 2012 Jan 14.


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