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Items: 1 to 20 of 67


An extended phase Ib study of epertinib, an orally active reversible dual EGFR/HER2 tyrosine kinase inhibitor, in patients with solid tumours.

Arkenau HT, Italiano A, Mak G, Toulmonde M, Baird RD, Garcia-Corbacho J, Plummer R, Flynn M, Forster M, Wilson RH, Tosi D, Adenis A, Donaldson K, Posner J, Kawabata I, Arimura A, Deva S, Spicer J.

Eur J Cancer. 2018 Nov;103:17-23. doi: 10.1016/j.ejca.2018.07.134. Epub 2018 Sep 6.


Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease.

Knight JM, Mandal P, Morlacchi P, Mak G, Li E, Madison M, Landers C, Saxton B, Felix E, Gilbert B, Sederstrom J, Varadhachary A, Singh MM, Chatterjee D, Corry DB, McMurray JS.

J Biol Chem. 2018 Jun 29;293(26):10026-10040. doi: 10.1074/jbc.RA117.000567. Epub 2018 May 8.


Towards an optimal treatment algorithm for metastatic pancreatic ductal adenocarcinoma (PDA).

Uccello M, Moschetta M, Mak G, Alam T, Henriquez CM, Arkenau HT.

Curr Oncol. 2018 Feb;25(1):e90-e94. doi: 10.3747/co.25.3708. Epub 2018 Feb 28. Review.


Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1/PD-L1 Blockade.

Moschetta M, Uccello M, Kasenda B, Mak G, McClelland A, Boussios S, Forster M, Arkenau HT.

Biomed Res Int. 2017;2017:1506824. doi: 10.1155/2017/1506824. Epub 2017 Nov 28.


Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours.

Nebot N, Arkenau HT, Infante JR, Chandler JC, Weickhardt A, Lickliter JD, Sarantopoulos J, Gordon MS, Mak G, St-Pierre A, Tang L, Mookerjee B, Carson SW, Hayes S, Grossmann KF.

Br J Clin Pharmacol. 2018 Apr;84(4):764-775. doi: 10.1111/bcp.13488. Epub 2018 Jan 23.


Pediatric Chondrosarcoma of the Sternum Resected with Thorascopic Assistance.

Bawa HS, Moore DD, Pelayo JC, Cipriani N, Mak G, Haydon RC.

Open Orthop J. 2017 May 31;11:479-485. doi: 10.2174/1874325001711010479. eCollection 2017.


Development of a multi-institutional clinical research consortium for pediatric surgery.

Hirschl RB, Minneci P, Gadepalli S, Saito JM, Askegard-Giesmann J, Deans K, Downard C, Fallat M, Finnell M, Helmrath M, Kabre R, Lal D, Leys C, Mak G, Ostlie D, Rescorla F, Sato T, St Peter S, von Allmen D, Warner B; MidWest Pediatric Surgery Consortium (MWPSC).

J Pediatr Surg. 2017 Jul;52(7):1084-1088. doi: 10.1016/j.jpedsurg.2016.11.042. Epub 2016 Dec 27.


Dabrafenib and trametinib activity in a patient with BRAF V600E mutated and microsatellite instability high (MSI-H) metastatic endometrial cancer.

Moschetta M, Mak G, Hauser J, Davies C, Uccello M, Arkenau HT.

Exp Hematol Oncol. 2017 Jan 10;6:1. doi: 10.1186/s40164-016-0061-2. eCollection 2017.


Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula.

Lal DR, Gadepalli SK, Downard CD, Ostlie DJ, Minneci PC, Swedler RM, Chelius T, Cassidy L, Rapp CT, Deans KJ, Fallat ME, Finnell SME, Helmrath MA, Hirschl RB, Kabre RS, Leys CM, Mak G, Raque J, Rescorla FJ, Saito JM, St Peter SD, von Allmen D, Warner BW, Sato TT; Midwest Pediatric Surgery Consortium.

J Pediatr Surg. 2017 Aug;52(8):1245-1251. doi: 10.1016/j.jpedsurg.2016.11.046. Epub 2016 Dec 5.


CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.

Zaunders J, Danta M, Bailey M, Mak G, Marks K, Seddiki N, Xu Y, Templeton DJ, Cooper DA, Boyd MA, Kelleher AD, Koelsch KK.

Front Immunol. 2016 Oct 24;7:438. eCollection 2016.


Bicuspid Aortic Valve Stenosis: Favorable Early Outcomes With a Next-Generation Transcatheter Heart Valve in a Multicenter Study.

Perlman GY, Blanke P, Dvir D, Pache G, Modine T, Barbanti M, Holy EW, Treede H, Ruile P, Neumann FJ, Gandolfo C, Saia F, Tamburino C, Mak G, Thompson C, Wood D, Leipsic J, Webb JG.

JACC Cardiovasc Interv. 2016 Apr 25;9(8):817-824. doi: 10.1016/j.jcin.2016.01.002.


The Impact of Mismatch Repair Status in Colorectal Cancer on the Decision to Treat With Adjuvant Chemotherapy: An Australian Population-Based Multicenter Study.

He EY, Hawkins NJ, Mak G, Roncolato F, Goldstein D, Liauw W, Clingan P, Chin M, Ward RL.

Oncologist. 2016 May;21(5):618-25. doi: 10.1634/theoncologist.2015-0530. Epub 2016 Mar 23.


Reporting incidental germline variants in the context of day-to-day somatic genomic profiling.

Mak G, Moschetta M, Arkenau HT.

Ann Oncol. 2016 May;27(5):758-9. doi: 10.1093/annonc/mdw078. Epub 2016 Feb 23. No abstract available.


Mitral Annular Dimensions and Geometry in Patients With Functional Mitral Regurgitation and Mitral Valve Prolapse: Implications for Transcatheter Mitral Valve Implantation.

Naoum C, Leipsic J, Cheung A, Ye J, Bilbey N, Mak G, Berger A, Dvir D, Arepalli C, Grewal J, Muller D, Murphy D, Hague C, Piazza N, Webb J, Blanke P.

JACC Cardiovasc Imaging. 2016 Mar;9(3):269-80. doi: 10.1016/j.jcmg.2015.08.022. Epub 2016 Feb 17.


The Geographic Distribution of Liver Cancer in Canada Does Not Associate with Cyanobacterial Toxin Exposure.

Labine MA, Green C, Mak G, Xue L, Nowatzki J, Griffith J, Minuk GY.

Int J Environ Res Public Health. 2015 Nov 30;12(12):15143-53. doi: 10.3390/ijerph121214969.


Long-Acting Beta Agonists Enhance Allergic Airway Disease.

Knight JM, Mak G, Shaw J, Porter P, McDermott C, Roberts L, You R, Yuan X, Millien VO, Qian Y, Song LZ, Frazier V, Kim C, Kim JJ, Bond RA, Milner JD, Zhang Y, Mandal PK, Luong A, Kheradmand F, McMurray JS, Corry DB.

PLoS One. 2015 Nov 25;10(11):e0142212. doi: 10.1371/journal.pone.0142212. eCollection 2015.


Differential left ventricular outflow tract remodeling and dynamics in aortic stenosis.

Mehrotra P, Flynn AW, Jansen K, Tan TC, Mak G, Julien HM, Zeng X, Picard MH, Passeri JJ, Hung J.

J Am Soc Echocardiogr. 2015 Nov;28(11):1259-66. doi: 10.1016/j.echo.2015.07.018. Epub 2015 Aug 22.


The Effects of Web-Based Patient Access to Laboratory Results in British Columbia: A Patient Survey on Comprehension and Anxiety.

Mák G, Smith Fowler H, Leaver C, Hagens S, Zelmer J.

J Med Internet Res. 2015 Aug 4;17(8):e191. doi: 10.2196/jmir.4350.


Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Gurden MD, Westwood IM, Faisal A, Naud S, Cheung KM, McAndrew C, Wood A, Schmitt J, Boxall K, Mak G, Workman P, Burke R, Hoelder S, Blagg J, Van Montfort RL, Linardopoulos S.

Cancer Res. 2015 Aug 15;75(16):3340-54. doi: 10.1158/0008-5472.CAN-14-3272. Epub 2015 Jul 22.


Airway fibrinogenolysis and the initiation of allergic inflammation.

Millien VO, Lu W, Mak G, Yuan X, Knight JM, Porter P, Kheradmand F, Corry DB.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S277-83. doi: 10.1513/AnnalsATS.201403-105AW. Review.

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