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Items: 1 to 20 of 30

1.

Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.

Chen HY, Plummer CW, Xiao D, Chobanian HR, DeMong D, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Di Salvo J, Thomas-Fowlkes B, Souza S, Tatosian DA, Chen Q, Hafey MJ, Houle R, Nolting AF, Orr R, Ehrhart J, Weinglass AB, Tschirret-Guth R, Howard AD, Colletti SL.

ACS Med Chem Lett. 2018 Jun 14;9(7):685-690. doi: 10.1021/acsmedchemlett.8b00149. eCollection 2018 Jul 12.

PMID:
30034601
2.

GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent.

Pachanski MJ, Kirkland ME, Kosinski DT, Mane J, Cheewatrakoolpong B, Xue J, Szeto D, Forrest G, Miller C, Bunzel M, Plummer CW, Chobanian HR, Miller MW, Souza S, Thomas-Fowlkes BS, Ogawa AM, Weinglass AB, Di Salvo J, Li X, Feng Y, Tatosian DA, Howard AD, Colletti SL, Trujillo ME.

PLoS One. 2017 Oct 20;12(10):e0186033. doi: 10.1371/journal.pone.0186033. eCollection 2017.

3.

GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production.

Miller C, Pachanski MJ, Kirkland ME, Kosinski DT, Mane J, Bunzel M, Cao J, Souza S, Thomas-Fowlkes B, Di Salvo J, Weinglass AB, Li X, Myers RW, Knagge K, Carrington PE, Hagmann WK, Trujillo ME.

PLoS One. 2017 May 23;12(5):e0176182. doi: 10.1371/journal.pone.0176182. eCollection 2017.

4.

GPR40 reduces food intake and body weight through GLP-1.

Gorski JN, Pachanski MJ, Mane J, Plummer CW, Souza S, Thomas-Fowlkes BS, Ogawa AM, Weinglass AB, Di Salvo J, Cheewatrakoolpong B, Howard AD, Colletti SL, Trujillo ME.

Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E37-E47. doi: 10.1152/ajpendo.00435.2016. Epub 2017 Mar 14.

5.

Design and Synthesis of Novel, Selective GPR40 AgoPAMs.

Plummer CW, Clements MJ, Chen H, Rajagopalan M, Josien H, Hagmann WK, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Nolting AF, Orr R, Christensen M, Campeau LC, Wright MJ, Bugianesi R, Souza S, Zhang X, Di Salvo J, Weinglass AB, Tschirret-Guth R, Nargund R, Howard AD, Colletti SL.

ACS Med Chem Lett. 2017 Jan 23;8(2):221-226. doi: 10.1021/acsmedchemlett.6b00443. eCollection 2017 Feb 9.

6.

Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].

Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1333. doi: 10.1016/j.bmcl.2017.01.082. Epub 2017 Feb 4. No abstract available.

PMID:
28169160
7.

Preclinical Safety Assessment of Furostanol Glycoside-Based Standardized Fenugreek Seed Extract in Laboratory Rats.

Deshpande P, Mohan V, Ingavale D, Mane J, Pore M, Thakurdesai PhD P.

J Diet Suppl. 2017 Sep 3;14(5):521-541. doi: 10.1080/19390211.2016.1272659. Epub 2017 Feb 3.

PMID:
28156165
8.

Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.

Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5724-5728. doi: 10.1016/j.bmcl.2016.10.054. Epub 2016 Oct 24. Erratum in: Bioorg Med Chem Lett. 2017 Mar 1;27(5):1333.

PMID:
27815121
9.

The feasibility of coherent energy transfer in microtubules.

Craddock TJ, Friesen D, Mane J, Hameroff S, Tuszynski JA.

J R Soc Interface. 2014 Nov 6;11(100):20140677. doi: 10.1098/rsif.2014.0677.

10.

Trends in cesarean delivery: rate and indications.

Mittal S, Pardeshi S, Mayadeo N, Mane J.

J Obstet Gynaecol India. 2014 Aug;64(4):251-4. doi: 10.1007/s13224-013-0491-2. Epub 2014 Jan 3.

11.

Comparison of lymphocyte isolation methods for endoscopic biopsy specimens from the colonic mucosa.

Carrasco A, Mañe J, Santaolalla R, Pedrosa E, Mallolas J, Lorén V, Fernández M, Fernández-Bañares F, Rosinach M, Loras C, Forné M, Andújar X, Vidal J, Viver JM, Esteve M.

J Immunol Methods. 2013 Mar 29;389(1-2):29-37. doi: 10.1016/j.jim.2012.12.006. Epub 2012 Dec 30.

PMID:
23279944
12.

Discovery of small molecule inhibitors that interact with γ-tubulin.

Friesen DE, Barakat KH, Semenchenko V, Perez-Pineiro R, Fenske BW, Mane J, Wishart DS, Tuszynski JA.

Chem Biol Drug Des. 2012 May;79(5):639-52. doi: 10.1111/j.1747-0285.2012.01340.x. Epub 2012 Feb 15.

PMID:
22268380
13.

Bacteria and spontaneous experimental colitis: immunological changes.

Pedrosa E, Lorén V, Cabré E, Doménech E, Ojanguren I, Gassull MA, Mañé J.

Eur J Clin Invest. 2011 Oct;41(10):1047-53. doi: 10.1111/j.1365-2362.2011.02499.x. Epub 2011 Mar 9.

PMID:
21902690
14.

Therapeutic effect of antisecretory factor-rich egg yolk on the late phases of 2,4,6-trinitrobenzenesulphonic acid colitis in mice.

Mañé J, Lorén V, Pedrosa E, Ojanguren I, Domènech E, Gassull MA, Cabré E.

Br J Nutr. 2011 Nov;106(10):1522-8. doi: 10.1017/S0007114511002042. Epub 2011 Jul 1.

PMID:
21733301
15.

Apoptosis resistance of mucosal lymphocytes and IL-10 deficiency in patients with steroid-refractory Crohn's disease.

Santaolalla R, Mañé J, Pedrosa E, Lorén V, Fernández-Bañares F, Mallolas J, Carrasco A, Salas A, Rosinach M, Forné M, Espinós JC, Loras C, Donovan M, Puig P, Mañosa M, Gassull MA, Viver JM, Esteve M.

Inflamm Bowel Dis. 2011 Jul;17(7):1490-500. doi: 10.1002/ibd.21507. Epub 2010 Nov 8.

PMID:
21674705
16.

A mixture of Lactobacillus plantarum CECT 7315 and CECT 7316 enhances systemic immunity in elderly subjects. A dose-response, double-blind, placebo-controlled, randomized pilot trial.

Mañé J, Pedrosa E, Lorén V, Gassull MA, Espadaler J, Cuñé J, Audivert S, Bonachera MA, Cabré E.

Nutr Hosp. 2011 Jan-Feb;26(1):228-35.

17.

Computer assisted design of second-generation colchicine derivatives.

Huzil JT, Mane J, Tuszynski JA.

Interdiscip Sci. 2010 Jun;2(2):169-74. doi: 10.1007/s12539-010-0076-z. Epub 2010 May 1.

PMID:
20640786
18.

Ensemble-based virtual screening reveals dual-inhibitors for the p53-MDM2/MDMX interactions.

Barakat K, Mane J, Friesen D, Tuszynski J.

J Mol Graph Model. 2010 Feb 26;28(6):555-68. doi: 10.1016/j.jmgm.2009.12.003. Epub 2009 Dec 14.

PMID:
20056466
19.

Lactobacillus fermentum CECT 5716 prevents and reverts intestinal damage on TNBS-induced colitis in mice.

Mañé J, Lorén V, Pedrosa E, Ojanguren I, Xaus J, Cabré E, Domènech E, Gassull MA.

Inflamm Bowel Dis. 2009 Aug;15(8):1155-63. doi: 10.1002/ibd.20908.

PMID:
19266568
20.

Partial replacement of dietary (n-6) fatty acids with medium-chain triglycerides decreases the incidence of spontaneous colitis in interleukin-10-deficient mice.

Mañé J, Pedrosa E, Lorén V, Ojanguren I, Fluvià L, Cabré E, Rogler G, Gassull MA.

J Nutr. 2009 Mar;139(3):603-10. doi: 10.3945/jn.108.101170. Epub 2009 Jan 6.

PMID:
19126671

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