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Regulation of Cellular Metabolism through Phase Separation of Enzymes.

Prouteau M, Loewith R.

Biomolecules. 2018 Dec 3;8(4). pii: E160. doi: 10.3390/biom8040160. Review.


Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.

Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R.

Nat Cell Biol. 2018 Sep;20(9):1043-1051. doi: 10.1038/s41556-018-0150-z. Epub 2018 Aug 27.


Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.

Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R.

J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12.


Systematic analysis of complex genetic interactions.

Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL.

Science. 2018 Apr 20;360(6386). pii: eaao1729. doi: 10.1126/science.aao1729.


Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.

Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith R, Schaffitzel C.

Nat Commun. 2017 Nov 23;8(1):1729. doi: 10.1038/s41467-017-01862-0.


TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.

Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R.

Nature. 2017 Oct 12;550(7675):265-269. doi: 10.1038/nature24021. Epub 2017 Oct 4.


Tensing Up for Lipid Droplet Formation.

Roux A, Loewith R.

Dev Cell. 2017 Jun 19;41(6):571-572. doi: 10.1016/j.devcel.2017.06.001. Review.


Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.

Primo C, Ferri-Blázquez A, Loewith R, Yenush L.

J Biol Chem. 2017 Jan 13;292(2):563-574. doi: 10.1074/jbc.M116.746982. Epub 2016 Nov 28.


TORC2 Structure and Function.

Gaubitz C, Prouteau M, Kusmider B, Loewith R.

Trends Biochem Sci. 2016 Jun;41(6):532-545. doi: 10.1016/j.tibs.2016.04.001. Epub 2016 May 5. Review.


A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SA, Baetz K.

Sci Rep. 2016 Jan 13;6:19332. doi: 10.1038/srep19332.


TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.

Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, Boone C, Ammerer G, Baranov PV, Loewith R.

Mol Biol Cell. 2016 Jan 15;27(2):397-409. doi: 10.1091/mbc.E15-08-0594. Epub 2015 Nov 18.


TOR Complexes and the Maintenance of Cellular Homeostasis.

Eltschinger S, Loewith R.

Trends Cell Biol. 2016 Feb;26(2):148-159. doi: 10.1016/j.tcb.2015.10.003. Epub 2015 Nov 4. Review.


Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R.

Mol Cell. 2015 Jun 18;58(6):977-88. doi: 10.1016/j.molcel.2015.04.031. Epub 2015 May 28.


Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.

Rispal D, Eltschinger S, Stahl M, Vaga S, Bodenmiller B, Abraham Y, Filipuzzi I, Movva NR, Aebersold R, Helliwell SB, Loewith R.

J Biol Chem. 2015 Jun 12;290(24):14963-78. doi: 10.1074/jbc.M114.627794. Epub 2015 Apr 16.


Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.

da Silveira Dos Santos AX, Riezman I, Aguilera-Romero MA, David F, Piccolis M, Loewith R, Schaad O, Riezman H.

Mol Biol Cell. 2014 Oct 15;25(20):3234-46. doi: 10.1091/mbc.E14-03-0851. Epub 2014 Aug 20.


Roles for PI(3,5)P2 in nutrient sensing through TORC1.

Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS.

Mol Biol Cell. 2014 Apr;25(7):1171-85. doi: 10.1091/mbc.E14-01-0021. Epub 2014 Jan 29.


A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

Kennedy MA, Gable K, Niewola-Staszkowska K, Abreu S, Johnston A, Harris LJ, Reggiori F, Loewith R, Dunn T, Bennett SA, Baetz K.

PLoS Genet. 2014 Jan;10(1):e1004010. doi: 10.1371/journal.pgen.1004010. Epub 2014 Jan 23.


TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM.

Mol Cell. 2013 Sep 26;51(6):829-39. doi: 10.1016/j.molcel.2013.08.019. Epub 2013 Sep 12.


Growth control: function follows form.

Loewith R.

Curr Biol. 2013 Jul 22;23(14):R607-9. doi: 10.1016/j.cub.2013.05.048.


Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway.

Chen J, Young SM, Allen C, Waller A, Ursu O, Strouse JJ, Yao T, Golden JE, Peterson BR, Foutz TD, Chavez SE, Perez D, Evangelisti AM, Garcia MJ, Bologa CG, Carter MB, Salas VM, Oprea TI, Edwards BS, Panchaud N, De Virgilio C, Seeber A, Loewith R, Manzanilla E, Werner-Washburne M, Aubé J, Sklar LA.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Apr 15 [updated 2013 Feb 25].

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