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Items: 1 to 20 of 79


A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans.

Lucanic M, Garrett T, Gill MS, Lithgow GJ.

J Vis Exp. 2018 Mar 20;(133). doi: 10.3791/56892.


A long journey to reproducible results.

Lithgow GJ, Driscoll M, Phillips P.

Nature. 2017 Aug 22;548(7668):387-388. doi: 10.1038/548387a. No abstract available.


Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease.

Leonoudakis D, Rane A, Angeli S, Lithgow GJ, Andersen JK, Chinta SJ.

Mediators Inflamm. 2017;2017:8302636. doi: 10.1155/2017/8302636. Epub 2017 Apr 4.


Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.

Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC.

Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256.


Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ.

Cell Rep. 2016 Oct 25;17(5):1227-1237. doi: 10.1016/j.celrep.2016.09.086.


A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZS, Kapahi P.

Curr Biol. 2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20.


Chemical activation of a food deprivation signal extends lifespan.

Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ.

Aging Cell. 2016 Oct;15(5):832-41. doi: 10.1111/acel.12492. Epub 2016 May 24.


Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P.

PLoS One. 2016 Apr 14;11(4):e0153513. doi: 10.1371/journal.pone.0153513. eCollection 2016.


Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.

Martins R, Lithgow GJ, Link W.

Aging Cell. 2016 Apr;15(2):196-207. doi: 10.1111/acel.12427. Epub 2015 Dec 8. Review.


Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin.

Siddiqui A, Bhaumik D, Chinta SJ, Rane A, Rajagopalan S, Lieu CA, Lithgow GJ, Andersen JK.

J Neurosci. 2015 Sep 16;35(37):12833-44. doi: 10.1523/JNEUROSCI.0109-15.2015.


Iron promotes protein insolubility and aging in C. elegans.

Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ.

Aging (Albany NY). 2014 Nov;6(11):975-91.


Geroscience: linking aging to chronic disease.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F.

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.


Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.

Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, Andersen JK.

Metallomics. 2014 Oct;6(10):1816-23. doi: 10.1039/c4mt00168k. Epub 2014 Jul 24.


Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity.

Epel ES, Lithgow GJ.

J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S10-6. doi: 10.1093/gerona/glu055. Review.


Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans.

Brejning J, Nørgaard S, Schøler L, Morthorst TH, Jakobsen H, Lithgow GJ, Jensen LT, Olsen A.

Aging Cell. 2014 Feb;13(1):156-64. doi: 10.1111/acel.12165. Epub 2013 Nov 28.


A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans.

Angeli S, Klang I, Sivapatham R, Mark K, Zucker D, Bhaumik D, Lithgow GJ, Andersen JK.

Aging (Albany NY). 2013 Oct;5(10):759-69.


Age-related micro-RNA abundance in individual C. elegans.

Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow GJ, Melov S.

Aging (Albany NY). 2013 Jun;5(6):394-411.


Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid.

Frankowski H, Alavez S, Spilman P, Mark KA, Nelson JD, Mollahan P, Rao RV, Chen SF, Lithgow GJ, Ellerby HM.

Mech Ageing Dev. 2013 Mar;134(3-4):69-78. doi: 10.1016/j.mad.2012.10.002. Epub 2013 Jan 11.


Curcumin and neurodegenerative diseases.

Monroy A, Lithgow GJ, Alavez S.

Biofactors. 2013 Jan-Feb;39(1):122-32. doi: 10.1002/biof.1063. Epub 2013 Jan 10. Review.


Tor1 regulates protein solubility in Saccharomyces cerevisiae.

Peters TW, Rardin MJ, Czerwieniec G, Evani US, Reis-Rodrigues P, Lithgow GJ, Mooney SD, Gibson BW, Hughes RE.

Mol Biol Cell. 2012 Dec;23(24):4679-88. doi: 10.1091/mbc.E12-08-0620. Epub 2012 Oct 24.

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