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Rocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia in vivo in a mouse xenogtraft model.

Wu Y, Giaisi M, Köhler R, Chen WM, Krammer PH, Li-Weber M.

Cancer Lett. 2017 Mar 28;389:70-77. doi: 10.1016/j.canlet.2016.12.010.


The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.

Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M.

Oncotarget. 2016 Aug 9;7(32):51908-51921. doi: 10.18632/oncotarget.10188.


HTLV-1-associated adult T cell leukemia is highly susceptible to Navitoclax due to enhanced Bax expression.

Witzens-Harig M, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2016 Jan 15;138(2):507-14. doi: 10.1002/ijc.29726.


Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.

Neumann J, Yang Y, Köhler R, Giaisi M, Witzens-Harig M, Liu D, Krammer PH, Lin W, Li-Weber M.

Int J Cancer. 2015 Dec 1;137(11):2739-48. doi: 10.1002/ijc.29629.


Dolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor activities.

Yang Y, Zhang Y, Liu D, Li-Weber M, Shao B, Lin W.

Fitoterapia. 2015 Jun;103:277-82. doi: 10.1016/j.fitote.2015.04.016.


Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.

Mühleisen A, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Dec 18;5:e1575. doi: 10.1038/cddis.2014.536.


Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).

Li-Weber M.

Int J Cancer. 2015 Oct 15;137(8):1791-9. doi: 10.1002/ijc.29013. Review.


Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.

Polier G, Giaisi M, Köhler R, Müller WW, Lutz C, Buss EC, Krammer PH, Li-Weber M.

Int J Cancer. 2015 Feb 1;136(3):688-98. doi: 10.1002/ijc.29009.


The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.

Becker MS, Schmezer P, Breuer R, Haas SF, Essers MA, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Jan 16;5:e1000. doi: 10.1038/cddis.2013.528.


The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints.

Neumann J, Boerries M, Köhler R, Giaisi M, Krammer PH, Busch H, Li-Weber M.

Int J Cancer. 2014 Apr 15;134(8):1991-2002. doi: 10.1002/ijc.28521.


The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells.

Bourkoula K, Englert C, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2014 Jan 15;134(2):291-300. doi: 10.1002/ijc.28379.


Targeting the IL-4/IL-13 signaling pathway sensitizes Hodgkin lymphoma cells to chemotherapeutic drugs.

Natoli A, Lüpertz R, Merz C, Müller WW, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2013 Oct 15;133(8):1945-54. doi: 10.1002/ijc.28189.


The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.

Polier G, Neumann J, Thuaud F, Ribeiro N, Gelhaus C, Schmidt H, Giaisi M, Köhler R, Müller WW, Proksch P, Leippe M, Janssen O, Désaubry L, Krammer PH, Li-Weber M.

Chem Biol. 2012 Sep 21;19(9):1093-104. doi: 10.1016/j.chembiol.2012.07.012.


Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation.

Kliem C, Merling A, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

J Biol Chem. 2012 Mar 23;287(13):10200-9. doi: 10.1074/jbc.M111.318733.


Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas.

Giaisi M, Köhler R, Fulda S, Krammer PH, Li-Weber M.

Int J Cancer. 2012 Aug 15;131(4):1003-8. doi: 10.1002/ijc.26458.


Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae).

Ebada SS, Lajkiewicz N, Porco JA Jr, Li-Weber M, Proksch P.

Prog Chem Org Nat Prod. 2011;94:1-58. doi: 10.1007/978-3-7091-0748-5_1. Review. No abstract available.


Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

Polier G, Ding J, Konkimalla BV, Eick D, Ribeiro N, Köhler R, Giaisi M, Efferth T, Desaubry L, Krammer PH, Li-Weber M.

Cell Death Dis. 2011 Jul 21;2:e182. doi: 10.1038/cddis.2011.66.


Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression.

Bleumink M, Köhler R, Giaisi M, Proksch P, Krammer PH, Li-Weber M.

Cell Death Differ. 2011 Feb;18(2):362-70. doi: 10.1038/cdd.2010.99.


Targeting apoptosis pathways in cancer by Chinese medicine.

Li-Weber M.

Cancer Lett. 2013 May 28;332(2):304-12. doi: 10.1016/j.canlet.2010.07.015. Review.

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