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Items: 1 to 20 of 90

1.

Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.

Zhou D, Ota K, Nardin C, Feldman M, Widman A, Wind O, Simon A, Reilly M, Levin LR, Buck J, Wakamatsu K, Ito S, Zippin JH.

Sci Signal. 2018 Nov 6;11(555). pii: eaau7987. doi: 10.1126/scisignal.aau7987.

PMID:
30401788
2.

Pharmacological modulation of the CO2/HCO3-/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.

Wiggins SV, Steegborn C, Levin LR, Buck J.

Pharmacol Ther. 2018 Oct;190:173-186. doi: 10.1016/j.pharmthera.2018.05.008. Epub 2018 May 26. Review.

PMID:
29807057
3.

Distinct intracellular sAC-cAMP domains regulate ER Ca2+ signaling and OXPHOS function.

Valsecchi F, Konrad C, D'Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magranè J, Starkov A, Buck J, Levin LR, Manfredi G.

J Cell Sci. 2017 Nov 1;130(21):3713-3727. doi: 10.1242/jcs.206318. Epub 2017 Sep 1.

4.

Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.

Gandhi JK, Roy Chowdhury U, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD.

J Ocul Pharmacol Ther. 2017 Oct;33(8):574-581. doi: 10.1089/jop.2017.0027. Epub 2017 Jul 7.

5.

Soluble adenylyl cyclase is essential for proper lysosomal acidification.

Rahman N, Ramos-Espiritu L, Milner TA, Buck J, Levin LR.

J Gen Physiol. 2016 Oct;148(4):325-39. doi: 10.1085/jgp.201611606.

6.

Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.

Navarrete FA, Alvau A, Lee HC, Levin LR, Buck J, Leon PM, Santi CM, Krapf D, Mager J, Fissore RA, Salicioni AM, Darszon A, Visconti PE.

Sci Rep. 2016 Sep 15;6:33589. doi: 10.1038/srep33589.

7.

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C, Zippin JH, van den Heuvel J, Glickman JF, Steegborn C, Levin LR, Buck J.

Nat Chem Biol. 2016 Oct;12(10):838-44. doi: 10.1038/nchembio.2151. Epub 2016 Aug 22.

8.

The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.

Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH.

Oncotarget. 2016 Jul 19;7(29):45597-45607. doi: 10.18632/oncotarget.10056.

9.

Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C.

J Biol Chem. 2016 Apr 29;291(18):9776-84. doi: 10.1074/jbc.M115.708255. Epub 2016 Mar 9.

10.

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.

Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA.

J Exp Med. 2015 Jun 29;212(7):1021-41. doi: 10.1084/jem.20150354. Epub 2015 Jun 22.

11.

Physiological roles of acid-base sensors.

Levin LR, Buck J.

Annu Rev Physiol. 2015;77:347-62. doi: 10.1146/annurev-physiol-021014-071821. Epub 2014 Oct 17. Review.

PMID:
25340964
12.

The role of soluble adenylyl cyclase in health and disease.

Buck J, Levin LR.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2533-4. doi: 10.1016/j.bbadis.2014.09.009. Epub 2014 Oct 12. No abstract available.

13.

Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.

Martinez J, Stessin AM, Campana A, Hou J, Nikulina E, Buck J, Levin LR, Filbin MT.

J Neurosci. 2014 Jul 9;34(28):9281-9. doi: 10.1523/JNEUROSCI.1434-14.2014.

14.

A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.

Hess KC, Liu J, Manfredi G, Mühlschlegel FA, Buck J, Levin LR, Barrientos A.

FASEB J. 2014 Oct;28(10):4369-80. doi: 10.1096/fj.14-252890. Epub 2014 Jul 1.

15.

A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.

Chen X, Baumlin N, Buck J, Levin LR, Fregien N, Salathe M.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):750-60. doi: 10.1165/rcmb.2013-0542OC.

16.

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3727-32. doi: 10.1073/pnas.1322778111. Epub 2014 Feb 24.

17.

pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).

Rahman N, Buck J, Levin LR.

Front Physiol. 2013 Nov 25;4:343. doi: 10.3389/fphys.2013.00343. Review.

18.

Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.

Shahidullah M, Mandal A, Wei G, Levin LR, Buck J, Delamere NA.

Invest Ophthalmol Vis Sci. 2014 Jan 9;55(1):187-97. doi: 10.1167/iovs.13-12717.

19.

Thiol changes during epididymal maturation: a link to flagellar angulation in mouse spermatozoa?

Ijiri TW, Vadnais ML, Huang AP, Lin AM, Levin LR, Buck J, Gerton GL.

Andrology. 2014 Jan;2(1):65-75. doi: 10.1111/j.2047-2927.2013.00147.x. Epub 2013 Nov 20.

20.

Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.

Wertheimer E, Krapf D, de la Vega-Beltran JL, Sánchez-Cárdenas C, Navarrete F, Haddad D, Escoffier J, Salicioni AM, Levin LR, Buck J, Mager J, Darszon A, Visconti PE.

J Biol Chem. 2013 Dec 6;288(49):35307-20. doi: 10.1074/jbc.M113.489476. Epub 2013 Oct 15.

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