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Items: 1 to 20 of 143


Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents.

Lottrup G, Belling K, Leffers H, Nielsen JE, Dalgaard MD, Juul A, Skakkebæk NE, Brunak S, Rajpert-De Meyts E.

Mol Hum Reprod. 2017 May 1;23(5):339-354. doi: 10.1093/molehr/gax012.


Chromosome-wise Protein Interaction Patterns and Their Impact on Functional Implications of Large-Scale Genomic Aberrations.

Kirk IK, Weinhold N, Belling K, Skakkebæk NE, Jensen TS, Leffers H, Juul A, Brunak S.

Cell Syst. 2017 Mar 22;4(3):357-364.e3. doi: 10.1016/j.cels.2017.01.001. Epub 2017 Feb 15.


Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice.

Doroszko M, Chrusciel M, Belling K, Vuorenoja S, Dalgaard M, Leffers H, Nielsen HB, Huhtaniemi I, Toppari J, Rahman NA.

Mol Cell Endocrinol. 2017 Mar 15;444:9-18. doi: 10.1016/j.mce.2017.01.036. Epub 2017 Jan 25.


Expression patterns of DLK1 and INSL3 identify stages of Leydig cell differentiation during normal development and in testicular pathologies, including testicular cancer and Klinefelter syndrome.

Lottrup G, Nielsen JE, Maroun LL, Møller LM, Yassin M, Leffers H, Skakkebæk NE, Rajpert-De Meyts E.

Hum Reprod. 2014 Aug;29(8):1637-50. doi: 10.1093/humrep/deu124. Epub 2014 Jun 7.


Transcriptome profiling of mice testes following low dose irradiation.

Belling KC, Tanaka M, Dalgaard MD, Nielsen JE, Nielsen HB, Brunak S, Almstrup K, Leffers H.

Reprod Biol Endocrinol. 2013 May 28;11:50. doi: 10.1186/1477-7827-11-50.


Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer.

Edsgärd D, Dalgaard MD, Weinhold N, Wesolowska-Andersen A, Rajpert-De Meyts E, Ottesen AM, Juul A, Skakkebæk NE, Skøt Jensen T, Gupta R, Leffers H, Brunak S.

Front Endocrinol (Lausanne). 2013 Jan 29;4:2. doi: 10.3389/fendo.2013.00002. eCollection 2013.


Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo.

Blomberg Jensen M, Jørgensen A, Nielsen JE, Steinmeyer A, Leffers H, Juul A, Rajpert-De Meyts E.

Neoplasia. 2012 Oct;14(10):952-63.


Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis.

Kristensen DM, Lesné L, Le Fol V, Desdoits-Lethimonier C, Dejucq-Rainsford N, Leffers H, Jégou B.

Int J Androl. 2012 Jun;35(3):377-84. doi: 10.1111/j.1365-2605.2012.01282.x.


MicroRNA expression profiling of carcinoma in situ cells of the testis.

Novotny GW, Belling KC, Bramsen JB, Nielsen JE, Bork-Jensen J, Almstrup K, Sonne SB, Kjems J, Rajpert-De Meyts E, Leffers H.

Endocr Relat Cancer. 2012 May 24;19(3):365-79. doi: 10.1530/ERC-11-0271. Print 2012 Jun.


Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality.

Blomberg Jensen M, Jørgensen A, Nielsen JE, Bjerrum PJ, Skalkam M, Petersen JH, Egeberg DL, Bangsbøll S, Andersen AN, Skakkebaek NE, Juul A, Rajpert-De Meyts E, Dissing S, Leffers H, Jørgensen N.

Int J Androl. 2012 Aug;35(4):499-510. doi: 10.1111/j.1365-2605.2012.01256.x. Epub 2012 Mar 9.


A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation.

Dalgaard MD, Weinhold N, Edsgärd D, Silver JD, Pers TH, Nielsen JE, Jørgensen N, Juul A, Gerds TA, Giwercman A, Giwercman YL, Cohn-Cedermark G, Virtanen HE, Toppari J, Daugaard G, Jensen TS, Brunak S, Rajpert-De Meyts E, Skakkebæk NE, Leffers H, Gupta R.

J Med Genet. 2012 Jan;49(1):58-65. doi: 10.1136/jmedgenet-2011-100174. Epub 2011 Dec 3.


A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples.

Nielsen JE, Kristensen DM, Almstrup K, Jørgensen A, Olesen IA, Jacobsen GK, Horn T, Skakkebaek NE, Leffers H, Rajpert-De Meyts E.

Andrologia. 2012 Apr;44(2):78-85. doi: 10.1111/j.1439-0272.2010.01108.x. Epub 2011 Feb 16.


Cost-effective multiplexing before capture allows screening of 25 000 clinically relevant SNPs in childhood acute lymphoblastic leukemia.

Wesolowska A, Dalgaard MD, Borst L, Gautier L, Bak M, Weinhold N, Nielsen BF, Helt LR, Audouze K, Nersting J, Tommerup N, Brunak S, Sicheritz-Ponten T, Leffers H, Schmiegelow K, Gupta R.

Leukemia. 2011 Jun;25(6):1001-6. doi: 10.1038/leu.2011.32. Epub 2011 Mar 18.


Many putative endocrine disruptors inhibit prostaglandin synthesis.

Kristensen DM, Skalkam ML, Audouze K, Lesné L, Desdoits-Lethimonier C, Frederiksen H, Brunak S, Skakkebæk NE, Jégou B, Hansen JB, Junker S, Leffers H.

Environ Health Perspect. 2011 Apr;119(4):534-41. doi: 10.1289/ehp.1002635. Epub 2010 Nov 16.


Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.

Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S, Skakkebaek NE, Nellemann C, Main KM, Jégou B, Leffers H.

Hum Reprod. 2011 Jan;26(1):235-44. doi: 10.1093/humrep/deq323. Epub 2010 Nov 8.


Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty.

Mouritsen A, Aksglaede L, Sørensen K, Mogensen SS, Leffers H, Main KM, Frederiksen H, Andersson AM, Skakkebaek NE, Juul A.

Int J Androl. 2010 Apr;33(2):346-59. doi: 10.1111/j.1365-2605.2010.01051.x. Review.


The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys.

Sørensen K, Aksglaede L, Petersen JH, Leffers H, Juul A.

J Clin Endocrinol Metab. 2010 Jun;95(6):2819-26. doi: 10.1210/jc.2009-2484. Epub 2010 Apr 9.


Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer.

Blomberg Jensen M, Andersen CB, Nielsen JE, Bagi P, Jørgensen A, Juul A, Leffers H.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):376-82. doi: 10.1016/j.jsbmb.2010.03.069. Epub 2010 Apr 1.


Expression of prostaglandin synthases (pgds and pges) during zebrafish gonadal differentiation.

Jørgensen A, Nielsen JE, Nielsen BF, Morthorst JE, Bjerregaard P, Leffers H.

Comp Biochem Physiol A Mol Integr Physiol. 2010 Sep;157(1):102-8. doi: 10.1016/j.cbpa.2010.03.014. Epub 2010 Mar 31.


Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract.

Blomberg Jensen M, Nielsen JE, Jørgensen A, Rajpert-De Meyts E, Kristensen DM, Jørgensen N, Skakkebaek NE, Juul A, Leffers H.

Hum Reprod. 2010 May;25(5):1303-11. doi: 10.1093/humrep/deq024. Epub 2010 Feb 18.


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