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Items: 1 to 20 of 143

1.

Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13.

Cariulo C, Verani M, Martufi P, Ingenito R, Finotto M, Deguire SM, Lavery DJ, Toledo-Sherman L, Lee R, Doherty EM, Vogt TF, Dominguez C, Lashuel HA, Petricca L, Caricasole A.

Biochem Biophys Res Commun. 2019 Oct 30. pii: S0006-291X(19)31827-3. doi: 10.1016/j.bbrc.2019.09.097. [Epub ahead of print]

PMID:
31677786
2.

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus.

Yalinca H, Gehin CJC, Oleinikovas V, Lashuel HA, Gervasio FL, Pastore A.

Front Mol Biosci. 2019 Oct 1;6:95. doi: 10.3389/fmolb.2019.00095. eCollection 2019.

3.

Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.

Burtscher J, Copin JC, Rodrigues J, Kumar ST, Chiki A, Guillot de Suduiraut I, Sandi C, Lashuel HA.

Neurobiol Aging. 2019 Aug 14;83:11-20. doi: 10.1016/j.neurobiolaging.2019.08.007. [Epub ahead of print]

4.

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.

Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, Deguire SM, Lashuel HA, Scaricamazza E, Sancesario GM, Schirinzi T, Mercuri NB, Sancesario G, Caricasole A, Petricca L.

Front Neurosci. 2019 Aug 22;13:889. doi: 10.3389/fnins.2019.00889. eCollection 2019.

5.

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.

Levine PM, Galesic A, Balana AT, Mahul-Mellier AL, Navarro MX, De Leon CA, Lashuel HA, Pratt MR.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1511-1519. doi: 10.1073/pnas.1808845116. Epub 2019 Jan 16.

6.

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding.

Ellmer D, Brehs M, Haj-Yahya M, Lashuel HA, Becker CFW.

Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1616-1620. doi: 10.1002/anie.201805238. Epub 2019 Jan 17.

7.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

DeGuire SM, Ruggeri FS, Fares MB, Chiki A, Cendrowska U, Dietler G, Lashuel HA.

J Biol Chem. 2018 Nov 30;293(48):18540-18558. doi: 10.1074/jbc.RA118.004621. Epub 2018 Sep 5.

8.

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection.

Etezadi D, Warner Iv JB, Ruggeri FS, Dietler G, Lashuel HA, Altug H.

Light Sci Appl. 2017 Aug 25;6(8):e17029. doi: 10.1038/lsa.2017.29. eCollection 2017 Aug.

9.

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.

Mollenhauer B, Bowman FD, Drake D, Duong J, Blennow K, El-Agnaf O, Shaw LM, Masucci J, Taylor P, Umek RM, Dunty JM, Smith CL, Stoops E, Vanderstichele H, Schmid AW, Moniatte M, Zhang J, Kruse N, Lashuel HA, Teunissen C, Schubert T, Dave KD, Hutten SJ, Zetterberg H.

J Neurochem. 2019 Apr;149(1):126-138. doi: 10.1111/jnc.14569. Epub 2018 Nov 13.

10.

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy.

Reif A, Chiki A, Ricci J, Lashuel HA.

J Vis Exp. 2018 Jun 27;(136). doi: 10.3791/57506.

11.

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

Ruggeri FS, Benedetti F, Knowles TPJ, Lashuel HA, Sekatskii S, Dietler G.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7230-7235. doi: 10.1073/pnas.1721220115. Epub 2018 Jun 25.

12.

Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces.

Rodrigo D, Tittl A, Ait-Bouziad N, John-Herpin A, Limaj O, Kelly C, Yoo D, Wittenberg NJ, Oh SH, Lashuel HA, Altug H.

Nat Commun. 2018 Jun 4;9(1):2160. doi: 10.1038/s41467-018-04594-x.

13.

Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas.

Etezadi D, Warner JB 4th, Lashuel HA, Altug H.

ACS Sens. 2018 Jun 22;3(6):1109-1117. doi: 10.1021/acssensors.8b00115. Epub 2018 Jun 12.

14.
15.

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM.

Protein Sci. 2018 Jul;27(7):1262-1274. doi: 10.1002/pro.3412.

16.

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.

Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T.

Neuron. 2017 Dec 20;96(6):1290-1302.e6. doi: 10.1016/j.neuron.2017.11.032.

17.

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.

Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz T, Lashuel HA.

Nat Commun. 2017 Nov 22;8(1):1678. doi: 10.1038/s41467-017-01575-4.

18.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.

Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10809-E10818. doi: 10.1073/pnas.1705372114. Epub 2017 Nov 21.

19.

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths.

Warner JB 4th, Ruff KM, Tan PS, Lemke EA, Pappu RV, Lashuel HA.

J Am Chem Soc. 2017 Oct 18;139(41):14456-14469. doi: 10.1021/jacs.7b06659. Epub 2017 Oct 9.

20.

Amyloid single-cell cytotoxicity assays by nanomotion detection.

Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G.

Cell Death Discov. 2017 Aug 21;3:17053. doi: 10.1038/cddiscovery.2017.53. eCollection 2017.

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