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Items: 1 to 20 of 90


Modeling the neuropsychiatric manifestations of Lowe syndrome using induced pluripotent stem cells: defective F-actin polymerization and WAVE-1 expression in neuronal cells.

Barnes J, Salas F, Mokhtari R, Dolstra H, Pedrosa E, Lachman HM.

Mol Autism. 2018 Aug 15;9:44. doi: 10.1186/s13229-018-0227-3. eCollection 2018.


Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons.

Wang P, Zhao D, Lachman HM, Zheng D.

Transl Psychiatry. 2018 Jan 10;8(1):13. doi: 10.1038/s41398-017-0058-6.


Characteristics of allelic gene expression in human brain cells from single-cell RNA-seq data analysis.

Zhao D, Lin M, Pedrosa E, Lachman HM, Zheng D.

BMC Genomics. 2017 Nov 10;18(1):860. doi: 10.1186/s12864-017-4261-x.


Transcriptome analysis of microglia in a mouse model of Rett syndrome: differential expression of genes associated with microglia/macrophage activation and cellular stress.

Zhao D, Mokhtari R, Pedrosa E, Birnbaum R, Zheng D, Lachman HM.

Mol Autism. 2017 Mar 29;8:17. doi: 10.1186/s13229-017-0134-z. eCollection 2017.


CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells.

Wang P, Mokhtari R, Pedrosa E, Kirschenbaum M, Bayrak C, Zheng D, Lachman HM.

Mol Autism. 2017 Mar 20;8:11. doi: 10.1186/s13229-017-0124-1. eCollection 2017.


The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review.

Mokhtari R, Lachman HM.

J Clin Cell Immunol. 2016 Dec;7(6). pii: 479. doi: 10.4172/2155-9899.1000479. Epub 2016 Dec 21.


Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion.

Lin M, Pedrosa E, Hrabovsky A, Chen J, Puliafito BR, Gilbert SR, Zheng D, Lachman HM.

BMC Syst Biol. 2016 Nov 15;10(1):105.


Neurons Derived From Patient-Specific Induced Pluripotent Stem Cells: a Promising Strategy Towards Developing Novel Pharmacotherapies for Autism Spectrum Disorders.

Mokhtari R, Lachman HM.

EBioMedicine. 2016 Jul;9:21-22. doi: 10.1016/j.ebiom.2016.06.036. Epub 2016 Jun 30. No abstract available.


Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks.

Nebel RA, Zhao D, Pedrosa E, Kirschen J, Lachman HM, Zheng D, Abrahams BS.

PLoS One. 2016 Jan 29;11(1):e0148039. doi: 10.1371/journal.pone.0148039. eCollection 2016.


Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders.

Lin M, Lachman HM, Zheng D.

Mol Cell Neurosci. 2016 Jun;73:32-42. doi: 10.1016/j.mcn.2015.11.009. Epub 2015 Nov 26. Review.


CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment.

Wang P, Lin M, Pedrosa E, Hrabovsky A, Zhang Z, Guo W, Lachman HM, Zheng D.

Mol Autism. 2015 Oct 19;6:55. doi: 10.1186/s13229-015-0048-6. eCollection 2015.


MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del.

Zhao D, Lin M, Chen J, Pedrosa E, Hrabovsky A, Fourcade HM, Zheng D, Lachman HM.

PLoS One. 2015 Jul 14;10(7):e0132387. doi: 10.1371/journal.pone.0132387. eCollection 2015.


ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin.

Chen J, Lin M, Hrabovsky A, Pedrosa E, Dean J, Jain S, Zheng D, Lachman HM.

PLoS One. 2015 Apr 23;10(4):e0124597. doi: 10.1371/journal.pone.0124597. eCollection 2015.


Comparison of REST cistromes across human cell types reveals common and context-specific functions.

Rockowitz S, Lien WH, Pedrosa E, Wei G, Lin M, Zhao K, Lachman HM, Fuchs E, Zheng D.

PLoS Comput Biol. 2014 Jun 12;10(6):e1003671. doi: 10.1371/journal.pcbi.1003671. eCollection 2014 Jun.


Heat shock alters the expression of schizophrenia and autism candidate genes in an induced pluripotent stem cell model of the human telencephalon.

Lin M, Zhao D, Hrabovsky A, Pedrosa E, Zheng D, Lachman HM.

PLoS One. 2014 Apr 15;9(4):e94968. doi: 10.1371/journal.pone.0094968. eCollection 2014.


Characterization of human pseudogene-derived non-coding RNAs for functional potential.

Guo X, Lin M, Rockowitz S, Lachman HM, Zheng D.

PLoS One. 2014 Apr 3;9(4):e93972. doi: 10.1371/journal.pone.0093972. eCollection 2014.


Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neurons.

Belinsky GS, Rich MT, Sirois CL, Short SM, Pedrosa E, Lachman HM, Antic SD.

Stem Cell Res. 2014 Jan;12(1):101-18. doi: 10.1016/j.scr.2013.09.014. Epub 2013 Oct 3.


Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts.

Chen J, Lin M, Foxe JJ, Pedrosa E, Hrabovsky A, Carroll R, Zheng D, Lachman HM.

PLoS One. 2013 Oct 3;8(10):e75682. doi: 10.1371/journal.pone.0075682. eCollection 2013.


Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.

Lin M, Hrabovsky A, Pedrosa E, Wang T, Zheng D, Lachman HM.

PLoS One. 2012;7(8):e44017. doi: 10.1371/journal.pone.0044017. Epub 2012 Aug 30.


RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders.

Lin M, Pedrosa E, Shah A, Hrabovsky A, Maqbool S, Zheng D, Lachman HM.

PLoS One. 2011;6(9):e23356. doi: 10.1371/journal.pone.0023356. Epub 2011 Sep 7.

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