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Items: 1 to 20 of 141

1.

Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats.

Casuso RA, Al-Fazazi S, Hidalgo-Gutierrez A, López LC, Plaza-Díaz J, Rueda-Robles A, Huertas JR.

Free Radic Biol Med. 2019 Jan 24;134:304-310. doi: 10.1016/j.freeradbiomed.2019.01.027. [Epub ahead of print]

PMID:
30685403
2.

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.

Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2019 Jan;11(1). pii: e9466. doi: 10.15252/emmm.201809466.

3.

CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway.

Kleiner G, Barca E, Ziosi M, Emmanuele V, Xu Y, Hidalgo-Gutierrez A, Qiao C, Tadesse S, Area-Gomez E, Lopez LC, Quinzii CM.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3708-3722. doi: 10.1016/j.bbadis.2018.09.002. Epub 2018 Sep 6.

4.

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC.

Sci Rep. 2018 Sep 18;8(1):14013. doi: 10.1038/s41598-018-32190-y.

5.

Characterization and effect of metal ions on the formation of the Thermus thermophilus Sco mixed disulfide intermediate.

Lopez LC, Mukhitov N, Handley LD, Hamme CS, Hofman CR, Euers L, McKinney JR, Piers AD, Wadler E, Hunsicker-Wang LM.

Protein Sci. 2018 Nov;27(11):1942-1954. doi: 10.1002/pro.3502. Epub 2018 Oct 3.

PMID:
30168216
6.

The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes.

Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Rusanova I, Rahim I, Escames G, López LC, Mokhtar DM, Acuña-Castroviejo D.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1330-1338. doi: 10.1093/gerona/gly059.

PMID:
29562315
7.

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.

Shen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, García-López S, Martinez-Ruiz L, Mendivil-Perez M, Soto-Mercado V, Acuña-Castroviejo D, Ortega-Arellano H, Carriel V, Diaz-Casado ME, Reiter RJ, Rusanova I, Nieto A, López LC, Escames G.

J Pineal Res. 2018 Apr;64(3). doi: 10.1111/jpi.12461. Epub 2018 Jan 9.

PMID:
29247557
8.

Bypassing human CoQ10 deficiency.

Herebian D, López LC, Distelmaier F.

Mol Genet Metab. 2018 Mar;123(3):289-291. doi: 10.1016/j.ymgme.2017.12.008. Epub 2017 Dec 9.

PMID:
29246431
9.

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

Díaz-Casado ME, Rusanova I, Aranda P, Fernández-Ortiz M, Sayed RKA, Fernández-Gil BI, Hidalgo-Gutiérrez A, Escames G, López LC, Acuña-Castroviejo D.

Zebrafish. 2018 Feb;15(1):15-26. doi: 10.1089/zeb.2017.1479. Epub 2017 Nov 29.

PMID:
29185873
10.

Allometric trends reveal distinct evolutionary trajectories for avian communication.

Torres IMD, Lopez LCS, de Araújo CB.

J Acoust Soc Am. 2017 Oct;142(4):1879. doi: 10.1121/1.5005495.

PMID:
29092573
11.

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.

López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López LC, Acuña-Castroviejo D.

PLoS One. 2017 Aug 11;12(8):e0183090. doi: 10.1371/journal.pone.0183090. eCollection 2017.

12.

The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency.

Quinzii CM, Luna-Sanchez M, Ziosi M, Hidalgo-Gutierrez A, Kleiner G, Lopez LC.

Front Physiol. 2017 Jul 25;8:525. doi: 10.3389/fphys.2017.00525. eCollection 2017. Review.

13.

Melatonin, clock genes and mitochondria in sepsis.

Acuña-Castroviejo D, Rahim I, Acuña-Fernández C, Fernández-Ortiz M, Solera-Marín J, Sayed RKA, Díaz-Casado ME, Rusanova I, López LC, Escames G.

Cell Mol Life Sci. 2017 Nov;74(21):3965-3987. doi: 10.1007/s00018-017-2610-1. Epub 2017 Aug 7. Review.

PMID:
28785808
14.

Antioxidant effect of exercise: Exploring the role of the mitochondrial complex I superassembly.

Huertas JR, Al Fazazi S, Hidalgo-Gutierrez A, López LC, Casuso RA.

Redox Biol. 2017 Oct;13:477-481. doi: 10.1016/j.redox.2017.07.009. Epub 2017 Jul 11.

15.

Detection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Herebian D, Seibt A, Smits SHJ, Bünning G, Freyer C, Prokisch H, Karall D, Wredenberg A, Wedell A, López LC, Mayatepek E, Distelmaier F.

Mol Genet Metab. 2017 Jul;121(3):216-223. doi: 10.1016/j.ymgme.2017.05.012. Epub 2017 May 20.

PMID:
28552678
16.

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

Mendivil-Perez M, Soto-Mercado V, Guerra-Librero A, Fernandez-Gil BI, Florido J, Shen YQ, Tejada MA, Capilla-Gonzalez V, Rusanova I, Garcia-Verdugo JM, Acuña-Castroviejo D, López LC, Velez-Pardo C, Jimenez-Del-Rio M, Ferrer JM, Escames G.

J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12415. Epub 2017 May 18.

PMID:
28423196
17.

Melatonin protects rats from radiotherapy-induced small intestine toxicity.

Fernández-Gil B, Moneim AE, Ortiz F, Shen YQ, Soto-Mercado V, Mendivil-Perez M, Guerra-Librero A, Acuña-Castroviejo D, Molina-Navarro MM, García-Verdugo JM, Sayed RK, Florido J, Luna JD, López LC, Escames G.

PLoS One. 2017 Apr 12;12(4):e0174474. doi: 10.1371/journal.pone.0174474. eCollection 2017.

18.

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

Rahim I, Djerdjouri B, Sayed RK, Fernández-Ortiz M, Fernández-Gil B, Hidalgo-Gutiérrez A, López LC, Escames G, Reiter RJ, Acuña-Castroviejo D.

J Pineal Res. 2017 Aug;63(1). doi: 10.1111/jpi.12410. Epub 2017 Apr 29.

PMID:
28370493
19.

Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis.

Fernández-Mosquera L, Diogo CV, Yambire KF, Santos GL, Luna Sánchez M, Bénit P, Rustin P, Lopez LC, Milosevic I, Raimundo N.

Sci Rep. 2017 Mar 27;7:45076. doi: 10.1038/srep45076.

20.

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2017 Jan;9(1):78-95. doi: 10.15252/emmm.201606345.

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