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SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice.

Börjesson AE, Farman HH, Movérare-Skrtic S, Engdahl C, Antal MC, Koskela A, Tuukkanen J, Carlsten H, Krust A, Chambon P, Sjögren K, Lagerquist MK, Windahl SH, Ohlsson C.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E912-8. doi: 10.1152/ajpendo.00488.2015. Epub 2016 Apr 5.


The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis.

Engdahl C, Börjesson AE, Forsman HF, Andersson A, Stubelius A, Krust A, Chambon P, Islander U, Ohlsson C, Carlsten H, Lagerquist MK.

Arthritis Res Ther. 2014 Jul 15;16(4):R150. doi: 10.1186/ar4612.


Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair.

Campbell L, Emmerson E, Williams H, Saville CR, Krust A, Chambon P, Mace KA, Hardman MJ.

J Invest Dermatol. 2014 Sep;134(9):2447-2457. doi: 10.1038/jid.2014.175. Epub 2014 Apr 9.


Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E283-90. doi: 10.1073/pnas.1322057111. Epub 2013 Dec 26.


Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable.

Handgraaf S, Riant E, Fabre A, Waget A, Burcelin R, Lière P, Krust A, Chambon P, Arnal JF, Gourdy P.

Diabetes. 2013 Dec;62(12):4098-108. doi: 10.2337/db13-0282. Epub 2013 Jul 31.


Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.

Seillet C, Rouquié N, Foulon E, Douin-Echinard V, Krust A, Chambon P, Arnal JF, Guéry JC, Laffont S.

J Immunol. 2013 Jun 1;190(11):5459-70. doi: 10.4049/jimmunol.1203312. Epub 2013 Apr 26.


The role of activation functions 1 and 2 of estrogen receptor-α for the effects of estradiol and selective estrogen receptor modulators in male mice.

Börjesson AE, Farman HH, Engdahl C, Koskela A, Sjögren K, Kindblom JM, Stubelius A, Islander U, Carlsten H, Antal MC, Krust A, Chambon P, Tuukkanen J, Lagerquist MK, Windahl SH, Ohlsson C.

J Bone Miner Res. 2013 May;28(5):1117-26. doi: 10.1002/jbmr.1842. Erratum in: J Bone Miner Res. 2013 Nov;28(11):2432.


Estrogen dependent activation function of ERβ is essential for the sexual behavior of mouse females.

Antal MC, Petit-Demoulière B, Meziane H, Chambon P, Krust A.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19822-7. doi: 10.1073/pnas.1217668109. Epub 2012 Nov 12.


Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.

Windahl SH, Saxon L, Börjesson AE, Lagerquist MK, Frenkel B, Henning P, Lerner UH, Galea GL, Meakin LB, Engdahl C, Sjögren K, Antal MC, Krust A, Chambon P, Lanyon LE, Price JS, Ohlsson C.

J Bone Miner Res. 2013 Feb;28(2):291-301. doi: 10.1002/jbmr.1754.


Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance.

Zhu L, Brown WC, Cai Q, Krust A, Chambon P, McGuinness OP, Stafford JM.

Diabetes. 2013 Feb;62(2):424-34. doi: 10.2337/db11-1718. Epub 2012 Sep 10.


Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk.

Emmerson E, Campbell L, Davies FC, Ross NL, Ashcroft GS, Krust A, Chambon P, Hardman MJ.

J Invest Dermatol. 2012 Dec;132(12):2838-48. doi: 10.1038/jid.2012.228. Epub 2012 Jul 19.


Stromal estrogen receptor-α promotes tumor growth by normalizing an increased angiogenesis.

Péqueux C, Raymond-Letron I, Blacher S, Boudou F, Adlanmerini M, Fouque MJ, Rochaix P, Noël A, Foidart JM, Krust A, Chambon P, Brouchet L, Arnal JF, Lenfant F.

Cancer Res. 2012 Jun 15;72(12):3010-9. doi: 10.1158/0008-5472.CAN-11-3768. Epub 2012 Apr 20.


The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice.

Börjesson AE, Windahl SH, Karimian E, Eriksson EE, Lagerquist MK, Engdahl C, Antal MC, Krust A, Chambon P, Sävendahl L, Ohlsson C.

Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1381-9. doi: 10.1152/ajpendo.00646.2011. Epub 2012 Mar 13.


Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.

Illing A, Liu P, Ostermay S, Schilling A, de Haan G, Krust A, Amling M, Chambon P, Schinke T, Tuckermann JP.

Haematologica. 2012 Aug;97(8):1131-5. doi: 10.3324/haematol.2011.052456. Epub 2012 Feb 27.


Estrogen receptor-α expression in neuronal cells affects bone mass.

Ohlsson C, Engdahl C, Börjesson AE, Windahl SH, Studer E, Westberg L, Eriksson E, Koskela A, Tuukkanen J, Krust A, Chambon P, Carlsten H, Lagerquist MK.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):983-8. doi: 10.1073/pnas.1111436109. Epub 2012 Jan 3.


Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.

Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13311-6. doi: 10.1073/pnas.1105632108. Epub 2011 Jul 25.


Identification of estradiol/ERα-regulated genes in the mouse pituitary.

Kim HJ, Gieske MC, Trudgen KL, Hudgins-Spivey S, Kim BG, Krust A, Chambon P, Jeong JW, Blalock E, Ko C.

J Endocrinol. 2011 Sep;210(3):309-21. doi: 10.1530/JOE-11-0098. Epub 2011 Jun 23.


From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause.

Arnal JF, Lenfant F, Flouriot G, Tremollières F, Laurell H, Fontaine C, Krust A, Chambon P, Gourdy P.

Br J Pharmacol. 2012 Jan;165(1):57-66. doi: 10.1111/j.1476-5381.2011.01538.x. Review.


Genistein impairs early testosterone production in fetal mouse testis via estrogen receptor alpha.

Lehraiki A, Chamaillard C, Krust A, Habert R, Levacher C.

Toxicol In Vitro. 2011 Dec;25(8):1542-7. doi: 10.1016/j.tiv.2011.05.017. Epub 2011 May 23.


Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.

Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6288-93. doi: 10.1073/pnas.1100454108. Epub 2011 Mar 28.

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